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New computer model could replace stress tests for heart patients

NCT ID NCT06337461

Knowledge-focused Sponsor: Centro Cardiologico Monzino Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study aims to develop a computer model that can predict how well blood flows to the heart muscle during stress, using only a standard CT scan. Currently, this requires an additional scan and a drug to simulate stress. The researchers will analyze CT scans from 400 people with suspected coronary artery disease to build and test their model. If successful, this could simplify testing and improve risk assessment for heart disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

400 people

The number who actually took part.

Started

May 2023

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A total of 400 consecutive symptomatic patients with suspected CAD who were recruited for non-emergent, clinically indicated non-invasive coronary angiography with eventually dynamic stress computed tomography perfusion study

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Symptomatic patients with suspected CAD referred for nonemergent, clinically indicated non-invasive coronary angiography. Exclusion Criteria: * Low pre-test likelihood of CAD * Prior myocardial infarction * Previous history of revascularization * Acute coronary syndrome * Need for an emergent procedure * Evidence of clinical instability * Contraindication for contrast agent or impaired renal function * Inability to sustain a breath-hold * Pregnancy * Atrial fibrillation or flutter * BMI \> 35kg/m2 * Presence of pm or ICD * Contraindications to the administration of sublingual nitrates, betablockade, and adenosine

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic coronary syndrome

Contacts and locations

Locations

  • Centro Cardiologico Monzino

    Milan, Milan, 20131, Italy

More trials for these conditions

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