CHRONIC CORONARY SYNDROME

This study tests whether taking two blood thinners (prasugrel plus low-dose aspirin) for three months after heart bypass surgery is better than taking aspirin alone (either low or high dose) at preventing graft failure. About 1,700 adults with stable coronary artery disease who n…

This study compares two medical devices used to break up hard calcium deposits in heart arteries before placing a stent. It involves 50 adults with coronary artery disease who will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy. The goal i…

This study looks at whether a new drug called ZaStaprazan affects how well the blood thinner clopidogrel works in people who have had a heart procedure (stent placement). About 100 adults with chronic coronary syndrome will take either ZaStaprazan or a standard heartburn drug (PP…

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This nationwide trial tests whether intensive cholesterol-lowering drugs (statins plus ezetimibe or PCSK9 inhibitors) can slow plaque buildup in heart arteries better than standard statin therapy. About 766 adults aged 18–60 with chronic coronary syndrome and moderate artery bloc…

This study looks at whether people with chronic heart disease and a high risk of bleeding can stop taking antiplatelet drugs (blood thinners) one year after a balloon angioplasty procedure. Researchers will compare those who stop versus those who continue the medication, tracking…

This study tests whether artificial intelligence can analyze standard ultrasound images of the heart to measure calcium buildup on the aortic valve. If accurate, this could help doctors diagnose severe aortic stenosis without the extra cost and radiation of a CT scan. The study w…

This study compares two non-invasive tests for coronary heart disease: a CT scan of the heart arteries versus a stress ultrasound that also checks the neck arteries. The goal is to see which test better detects blockages and prevents heart attacks or other problems. 2,000 adults …

This study will enroll 246 people who have had a heart stent but still experience chest pain. Researchers will use a detailed diagnostic approach during a heart catheterization to identify whether the pain is due to new blockages, incomplete treatment, or other issues. The goal i…

This study looks for micro- and nanoplastics in the blood of the heart's arteries in 120 people with chronic coronary syndrome. Participants will have a standard heart CT and an angiogram, and a small blood sample from the heart will be tested for plastic particles. The goal is t…

This study aims to develop a computer model that can predict how well blood flows to the heart muscle during stress, using only a standard CT scan. Currently, this requires an additional scan and a drug to simulate stress. The researchers will analyze CT scans from 400 people wit…

This study looks at 570 people with chronic coronary syndrome (chest pain or shortness of breath due to narrowed heart arteries). Participants with abnormal blood flow on a PET scan will be randomly assigned to either immediate heart catheterization or a 3-month delay, while both…