Aggressive statins may halt artery clogging in young hearts

NCT ID NCT06896708

Recruiting now Disease control Sponsor: Liu yong Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This nationwide trial tests whether intensive cholesterol-lowering drugs (statins plus ezetimibe or PCSK9 inhibitors) can slow plaque buildup in heart arteries better than standard statin therapy. About 766 adults aged 18–60 with chronic coronary syndrome and moderate artery blockages will be randomly assigned to one of two treatment strategies. The goal is to see if driving LDL cholesterol below 1.0 mmol/L prevents plaque progression and reduces heart attacks or hospitalizations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intensive lipid-lowering therapy (atorvastatin or rosuvastatin plus ezetimibe or PCSK9 inhibitor)
What this could lead to: If successful, this could show that aggressive cholesterol lowering slows or stops artery plaque progression, reducing heart attack risk in younger patients.
What could go wrong: This is an open-label trial (no placebo), so results may be biased. The intensive regimen may cause more side effects like muscle pain or liver issues, and long-term benefits are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC CORONARY SYNDROME

Contacts and locations

Locations

Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, Guangdong, 510100, China
The Eighth Affiliated Hospital of Sun Yat-sen University
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518033, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400015, China
The First Affiliated Hospital of Dalian Medical University
NOT_YET_RECRUITING

Dalian, Liaoning, 116000, China
The Ninth Clinical Medical College of Guangzhou University of Chinese Medicine
NOT_YET_RECRUITING

Dongguan, Guangdong, 523000, China
The Third Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510000, China
Zhongshan People's Hospital
NOT_YET_RECRUITING

Zhongshan, Guangdong, 528400, China

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