Sound waves smash heart artery calcium in new device trial

NCT ID NCT05966662

Completed Disease control Sponsor: Shockwave Medical, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. It involved 145 people with severe coronary artery disease. The goal was to see if the device is safe and helps stents work better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Shockwave C2+ 2Hz Coronary IVL Catheter (a device that uses sound waves to break up calcium in heart arteries)
What this could lead to: If successful, this device could make stenting safer and more effective for people with heavily calcified coronary arteries.
What could go wrong: This is a single-arm study with no comparison group, so results may not apply to all patients. Risks include heart attack, need for repeat procedures, or device failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE MYOCARDIAL INFARCTION

Contacts and locations

Locations

Baylor Scott and White Research Institute

Dallas, Texas, 75226, United States
Charleston Area Medical Center

Charleston, West Virginia, 25304, United States
Essentia Health St. Mary's Heart & Vascular Center

Duluth, Minnesota, 55805, United States
Heart Center Research

Huntsville, Alabama, 35801, United States
Loyola University

Chicago, Illinois, 60153, United States
Medstar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Memorial Health

Hollywood, Florida, 33021, United States
Methodist Hospital

San Antonio, Texas, 78229, United States
Northwell Health/Lenox Hill

New York, New York, 11030, United States
Norton Heart and Vascular Institute

Louisville, Kentucky, 40205, United States
Scripps Clinic

La Jolla, California, 92121, United States
St. Francis Hospital

Roslyn, New York, 11576, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
The Christ Hospital

Cincinnati, Ohio, 45219, United States
UPMC Pinnacle Health

Harrisburg, Pennsylvania, 17110, United States
Washington University

St Louis, Missouri, 63110, United States
WellSpan Health - York

York, Pennsylvania, 17403, United States
Wellstar Kennestone Hospital

Marietta, Georgia, 30060, United States

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