New 3D imaging technique could replace pressure wire in heart artery procedures

NCT ID NCT04931771

Completed Disease control Sponsor: ECRI bv Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to one of the two methods. The goal is to see if vFFR can safely determine which blockages need a stent, potentially avoiding the need for a pressure wire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vFFR (3D-angiography-based vessel fractional flow reserve) and FFR (fractional flow reserve) devices
What this could lead to: If vFFR works as well as FFR, it could simplify heart artery assessments by avoiding the need for a pressure wire, making the procedure faster and less invasive.
What could go wrong: This is a non-inferiority trial, meaning it aims to show vFFR is not worse than FFR, not that it is better. The results may not apply to all patients or settings.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

AOU di Ferrara (Ospedale Sant'Anna)

Cona, Italy
Albert Schweitzer

Dordrecht, Netherlands
Amphia Ziekenhuis

Breda, Netherlands
Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, Italy
CHU LILLE - Institut Cœur Poumon

Lille, France
Cardiologia Ospedale Dell' Angelo

Mestre, Italy
Cardiologia Ospedale San Bortolo

Vicenza, Italy
Charité- Campus Benjamin Franklin

Berlin, Germany
Clinique Saint Hilaire

Rouen, France
Clinique St Martin

Caen, France
Clinique les Fontaines

Melun, France
Erasmus University Medical Center

Rotterdam, Netherlands
Golden Jubilee National Hospital

Glasgow, United Kingdom
Herz- und Diabeteszentrum NRW

Bad Oeynhausen, Germany
Hospital Clinic

Barcelona, Spain
Hospital Clinico Universitario de Valladolid

Valladolid, Spain
Hospital Univeritario A Coruna

A Coruña, Spain
Hospital Universitario Central de Asturias

Oviedo, Spain
Hospital Universitario de Leon

León, Spain
Hospital Universitario de la Princesa

Madrid, Spain
Hospital del Mar

Barcelona, Spain
Humanitas Research Hospital

Milan, Italy
Hôpital Privé Jacques Cartier

Massy, France
Hôpital de la Croix Rousse, hospices civils de lyon

Lyon, France
Institut Cardiovasculaire de Grenoble

Grenoble, France
John Radcliffe Hospital

Oxford, United Kingdom
La Paz

Madrid, Spain
Marienhaus Klinikum

Neuwied, Germany
Mater Private Cork

Cork, Ireland
Mater Private Dublin

Dublin, Ireland
Ospedale Maggiore della Carità

Novara, Italy
Pineta Grande Hospital

Naples, Italy
Policlinico San Donato

Milan, Italy
Royal Sussex County Hospital

Brighton, United Kingdom
SHG Klinik Völklingen

Völklingen, Germany
St James Hospital

Dublin, Ireland
Tergooi MC

Blaricum, Netherlands
UMCU

Utrecht, Netherlands
Unfallkrankenhaus Berlin

Berlin, Germany
Universitatsklinikum Dusseldorf

Düsseldorf, Germany

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