New CT scan analysis could spare thousands from unnecessary heart catheterizations

NCT ID NCT01943903

Completed Diagnosis Sponsor: HeartFlow, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a computer analysis of CT scans (called FFRCT) can better guide decisions about heart artery blockages compared to usual care. About 584 people with suspected coronary artery disease took part. The goal was to see if using FFRCT reduces the number of unnecessary invasive angiograms (where a tube is inserted into heart arteries).

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FFRCT (a computer analysis of CT scans to measure blood flow in heart arteries)
What this could lead to: If successful, this could show that FFRCT helps doctors diagnose blocked arteries more accurately, reducing the need for invasive tests.
What could go wrong: This is a completed study, so results are already known. The test may not work as well in all patients or settings, and it adds extra cost and time to standard CT scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

Aarhus University Hospital Skejby

Aarhus, 8200, Denmark
CHU Brest - Hopital de Cardiologie

Brest, 29609, France
Cardiovascular Center Aalst

Aalst, Belgium
Cardiovascular Hospital -Interventional Cardiology Dept, Hospices Civils de Lyon and Claude Bernard University France

Lyon, 69677, France
Centro Cardiologico Monzino

Milan, 20154, Italy
Deutsches Herzzentrum München - ISAResearch Centre

Munich, 80636, Germany
Duke University Clinical Research Institution

Durham, North Carolina, 27705, United States
Freeman Hospital - Therapeutics & Cardiac Research Team

Newcastle upon Tyne, NE7 7DN, United Kingdom
Heart Center Leipzig GmbH

Leipzig, 04289, Germany
HeartFlow, Inc

Redwood City, California, 94063, United States
Innsbruck Medical University, Department of Radiology II

Innsbruck, A-6020, Austria
LKH-GRAZ-West - Department of Cardiology

Graz, A-8020, Austria
Stanford University

Stanford, California, 94305, United States
University Hospital Southampton NHS Foundation Trust

Southampton, SO16 6YD, United Kingdom
Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, 55131, Germany

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