Could nerve blocks replace general anesthesia for leg amputations?
NCT ID NCT03404180
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks and sedation. The goal was to see if this approach could provide effective pain control and reduce complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Peripheral nerve block (procedure) and intravenous sedatives (propofol or dexmedetomidine)
What this could lead to
If successful, this approach could offer a safer alternative to general anesthesia for high-risk patients needing leg amputations, reducing complications and improving pain control.
What could go wrong
This is a small, single-site study with only 30 participants, so results may not apply to all patients. Nerve blocks may not always work as the main anesthetic, and sedation carries its own risks.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Florida
Gainesville, Florida, 32611, United States