Could nerve blocks replace general anesthesia for leg amputations?
NCT ID NCT03404180
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks and sedation. The goal was to see if this approach could provide effective pain control and reduce complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Peripheral nerve block (procedure) and intravenous sedatives (propofol or dexmedetomidine)
- What this could lead to
- If successful, this approach could offer a safer alternative to general anesthesia for high-risk patients needing leg amputations, reducing complications and improving pain control.
- What could go wrong
- This is a small, single-site study with only 30 participants, so results may not apply to all patients. Nerve blocks may not always work as the main anesthetic, and sedation carries its own risks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Florida
Gainesville, Florida, 32611, United States
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