Chest injection may lower anesthetic doses during heart surgery

NCT ID NCT03734159

Completed Symptom relief Sponsor: CMC Ambroise Paré Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assigned to receive either ropivacaine or a placebo before surgery. The goal was to see if the block could prevent dangerous spikes in heart rate and blood pressure without requiring high doses of anesthetics.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ropivacaine
What this could lead to: If it works, this could lead to a simple injection that reduces the amount of strong anesthetics needed during heart surgery, potentially improving safety.
What could go wrong: This is a small, completed Phase 4 trial with only 35 participants, so results may not apply to all patients. The block may not work as well in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder coronary restenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY BYPASS GRAFT STENOSIS

Contacts and locations

Locations

CMC Ambroise Paré

Neuilly-sur-Seine, Île-de-France Region, 92200, France

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