Heart valve surgery may change how we measure artery blockages

NCT ID NCT04420325

Completed Knowledge-focused Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at 116 patients with severe aortic stenosis and moderate coronary artery disease who were scheduled for valve replacement. Researchers measured blood flow in the heart arteries before, right after, and 6 months after valve replacement to see how the procedure affects standard tests for artery blockages. The goal was to improve accuracy in deciding which patients need additional artery treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better decide which patients with aortic stenosis also need treatment for blocked heart arteries.
What could go wrong: This is an observational study, not a treatment trial. It only measures changes and does not test a new therapy, so it cannot directly improve patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS CORONARY ARTERY DISEASE

Contacts and locations

Locations

AZ Delta

Roeselare, Belgium
UZ Leuven

Leuven, Vlaams-brabant, 3000, Belgium
University hospital Antwerp

Antwerp, Belgium

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