CORONARY ARTERY DISEASE

This study aims to see if a new type of heart stent called Freesolve is as safe and effective as a standard metal stent (Xience). Freesolve is made of magnesium and is designed to dissolve in the artery over time. The study will involve about 1,859 adults with clogged heart arter…

This study aims to find the best way to decide which blocked heart arteries need treatment in high-risk patients. It will compare two strategies: one that looks at the size and stability of the fatty buildup (plaque) inside the artery, and another that measures how much the block…

This study is preparing for a larger trial to see if regular singing can improve blood vessel health and lower future heart disease risk in older adults who already have coronary artery disease. Researchers will test whether group singing (in-person or virtual) or solo singing is…

This large study aims to compare two common procedures for treating blocked heart arteries. It will test whether using a drug-coated balloon is as safe and effective as implanting a drug-coated metal stent, especially for patients at high risk of bleeding who struggle with long-t…

This study is testing a new support program for Thai adults aged 60+ who have had a heart attack and a stent procedure. The program combines in-person education, personal counseling, and follow-up support through a mobile app. Researchers want to see if this approach helps people…

This study is for people with atrial fibrillation (AFib) and a history of a heart stent who have had a successful ablation procedure and have stayed in normal rhythm for at least a year. It aims to find out if it's safe to stop their blood thinner medication and switch to just a …

This study aims to see if a common artery-opening procedure (using a stent) combined with standard heart failure medications works better than the medications alone for people with a weak heart pump caused by clogged heart arteries. It will enroll about 650 adults who have heart …

This study aims to find the best way to prepare a re-narrowed heart stent before applying a drug-coated balloon. It will compare using more aggressive, cutting-type balloons against standard balloons in 500 patients. The goal is to see which preparation method leads to better lon…

This large study aims to see if using a detailed heart scan (coronary CTA) to guide treatment is better than standard care at preventing heart attacks, strokes, and death in high-risk adults in rural China. Nearly 15,000 people aged 40-75 with high cholesterol, diabetes, or kidne…

This study is testing a small mesh device called a coronary sinus reducer that's implanted in the heart to help reduce chest pain in people with advanced coronary artery disease. Researchers will measure how the device affects blood flow and pressure in the heart over 6 months in…

This study will test whether adding 12 virtual health coaching sessions over 16 weeks helps people recovering from heart attacks or heart failure. Researchers want to see if coaching improves weight management, reduces stress, increases medication adherence, and lowers hospital r…

This small pilot study is testing if a fecal microbiota transplant (FMT) can change the gut bacteria of people who have both type 2 diabetes and stable coronary artery disease. Researchers want to see if altering the gut microbiome can improve metabolic health and reduce inflamma…

This study aims to find out if mildly cooling the body during heart bypass surgery provides better protection against brain injury compared to keeping the body at normal temperature. Researchers will enroll 160 adults undergoing planned coronary artery bypass surgery and randomly…

This study is testing if a smartwatch with artificial intelligence (AI) can help people recover after a heart attack. It will see if the watch, worn for 3 months during rehab, can better monitor health, improve quality of life, and reduce return trips to the hospital compared to …

This study aims to determine whether it's safer for patients with clogged heart arteries to have their artery-opening procedure before or after they undergo other planned, time-sensitive surgeries like cancer operations. Researchers will compare two approaches in 140 patients: do…

This study compares a new heart pump device called the Supira System to existing Impella devices during high-risk artery-opening procedures. The goal is to see if the new device is as safe and effective at supporting patients' blood flow during these complex operations. About 358…

This study aims to see if a new 'hybrid' treatment for long, diffuse heart artery blockages is safe and works as well as the current standard. The new approach uses a temporary, dissolving scaffold and drug-coated balloons, aiming to leave no permanent metal behind. It will be co…

This study tests whether an inhaled medicine called Aroxxen® can protect heart muscle during and after stent placement surgery. Researchers will enroll 180 patients with coronary artery disease who are having elective stent procedures. The trial aims to find the best dose and tim…

This study will follow patients for at least 10 years to see which long-term approach is better for a completely blocked heart artery: implanting a drug-coated stent or using optimal medication alone. It aims to find out which treatment leads to fewer major heart problems, stroke…

This large study aims to find the best way to treat people with severe calcium buildup in their heart arteries before placing a stent. Researchers will compare two methods for breaking up the calcium (a shockwave device vs. standard balloons) and two methods for guiding stent pla…

This study compares two common heart procedures—bypass surgery (CABG) and stent placement (PCI)—for people with weakened heart pumps and multiple clogged arteries. Researchers will follow 358 patients for 4 years to see which approach leads to better survival, fewer heart problem…

This study is testing a robotic system designed to help doctors perform heart stent procedures (PCI) for coronary artery disease. Researchers will compare the robot to human operators to see if it is safe, effective, and can reduce procedure time and radiation exposure for both d…

This study aims to compare two different heart devices used to prevent strokes in people with a common heart rhythm problem called atrial fibrillation. The participants are at high risk for both strokes and serious bleeding, making long-term blood thinners a poor option. Doctors …

This study is testing if adding a PCSK9 inhibitor drug to standard cholesterol treatment right after a heart attack helps make artery plaque more stable and less likely to cause another event. It will involve 212 patients who recently had a heart attack. Doctors will use advanced…

This study aims to compare two different approaches for opening blocked heart arteries: drug-coated balloons versus drug-coated stents. It will enroll 1380 adults with coronary artery disease who have complex or small artery blockages. The goal is to see if balloons, which don't …

This study is testing a new computer-based decision tool designed to help doctors better protect cancer survivors from heart problems. The tool will be tested with 60 cancer survivors who are at risk for heart disease. Researchers want to see if the tool is easy for doctors and p…

This study is testing whether a new drug called ziltivekimab can help stabilize the fatty plaques in heart arteries after a heart attack. About 332 participants who recently had a heart attack will be randomly assigned to receive either the new drug or a placebo injection once a …

This study aims to determine if the heart rhythm medication flecainide is as safe as standard drugs (sotalol or amiodarone) for people who have both atrial fibrillation (an irregular heartbeat) and stable coronary artery disease (narrowed heart arteries). Researchers will randoml…

This study tests whether having a real-time online team of heart specialists make treatment decisions during a patient's heart scan leads to better outcomes than standard care. It involves 1,350 adults with both diabetes and severe blockages in all three main heart arteries. The …

This study is testing whether a thinner, more flexible medical tube is safer and works better for common heart artery procedures when performed through the wrist. It will involve 594 adults with naturally small wrist arteries. Researchers will compare the new thinner tube to a st…

This study is looking at a procedure called intravascular lithotripsy (IVL) for people with severe calcium buildup in their heart arteries. Doctors use a special balloon that sends pressure waves to crack the hard calcium, making it easier to place a stent to open the artery. The…

This study aims to find the best medication plan for people who have had a heart attack and received a stent. It will test two different strategies for blood thinners to reduce bleeding risk, and two different strategies for cholesterol-lowering drugs. The goal is to prevent futu…

This study aims to see if sending simple electronic information letters can encourage adults with heart disease to get their cholesterol checked and better manage their risk factors. It will involve 100,000 people in Denmark who will either receive these reminder letters or not, …

This study is testing a new support package for older adults who have two or more long-term health problems, like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support to help manage their health. Researchers w…

This study is testing whether a sensitive digital stethoscope can detect early heart disease by picking up subtle changes in heart sounds. Researchers will record heart sounds from 500 patients who are already scheduled for standard heart scans. The goal is to see if this simple …

This study aims to develop a new screening tool for heart and related diseases. Researchers will use a smartphone-compatible device to record a simple, 1-minute heart rhythm reading from 5,000 participants. They will then use artificial intelligence to see if patterns in this rea…

This study is testing a new way to perform heart scans (angiograms) that uses much less radiation. It aims to see if these low-radiation scans, enhanced with special software, are just as clear and useful for diagnosing heart problems as standard scans. The goal is to reduce long…

This study is testing a new AI software tool called CaRi-Heart® that analyzes standard heart CT scans to measure hidden inflammation in the arteries. The goal is to see if this extra information helps doctors make better decisions about treatment and early management for patients…

This study is testing whether an artificial intelligence (AI) tool can help emergency room doctors read heart scans more accurately and confidently. It will involve about 530 adults who come to the ER with chest pain. Doctors will be randomly assigned to read scans either with or…

This study is testing a new type of CT scanner designed specifically for heart imaging. It aims to see if this new technology can provide clearer, more detailed pictures of the heart's arteries compared to current standard scanners. The goal is to improve the diagnosis of coronar…

This study is testing if a new, faster AI-powered scan can guide heart stent placement as well as the current standard test, which requires inserting a special wire into the heart's arteries. It will involve about 2,100 adults with clogged heart arteries. The goal is to see if th…

This study is testing if a special type of CT scan can help emergency room doctors make better decisions for patients with chest pain who are at moderate risk for heart problems. It will compare the new scan approach to standard care for 2000 patients to see if it leads to fewer …

This study aims to find out which of two advanced heart scan methods is better at guiding treatment for people with blocked heart arteries. About 1,400 participants with a significant artery blockage will be randomly assigned to have their treatment decisions guided by either a s…

This study is testing if letting patients eat and drink normally before a scheduled heart catheterization is safe and makes them more comfortable. Researchers will compare two groups: one that follows the usual fasting rule and one that can eat as desired. They will check for bre…

This study tests whether showing patients a virtual reality simulation of their upcoming heart catheterization procedure reduces anxiety compared to standard education. About 120 first-time patients in Oman will either experience the VR simulation or receive regular preparation b…

This study is testing whether listening to guided meditation recordings can help reduce stress and anxiety in patients undergoing open-heart surgery. Researchers will compare 72 patients who receive the meditation sessions to those who receive standard care alone. They will measu…

This study aims to understand why some stroke patients get worse after a successful procedure to remove a blood clot. Researchers will use a non-invasive brain ultrasound on 100 patients to measure blood flow after the procedure. The goal is to find patterns that could help docto…

This study is testing a new computer decision-support system designed to help doctors follow the latest treatment guidelines for patients with high cholesterol and heart disease risk. Researchers will analyze the past medical records of 500 patients to see if the computer system'…

This study aims to gather information on how well a specific ultrasound-guided procedure works for treating complex heart blockages in patients from minority groups. It will follow about 1,010 patients for up to two years after their procedure to track their health outcomes. The …

This study aims to see if taking very detailed pictures of a heart artery blockage before a balloon procedure can help predict how well the treatment will work long-term. Researchers will look back at data from 600 patients who had this imaging and the balloon procedure, and also…

This study aims to create a better tool to predict which elderly patients with heart artery blockages might benefit most from procedures to open those arteries. Researchers will follow 800 patients aged 70+ for two years, using heart scans, blood tests, and measures of frailty to…

This study aims to understand how different treatments for blocked heart arteries affect kidney health over many years. Researchers will look back at the medical records of over 1,700 patients who received medication, stents, or bypass surgery. The goal is to see if one treatment…

This nationwide study in China aims to learn more about a specific, hard type of plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is difficult to treat. Researchers will use advanced imaging tools during standard heart procedures to see…

This study aims to understand how a low-dose anti-inflammatory drug (colchicine) changes the mix of proteins in the blood of people with coronary heart disease who still have inflammation. Researchers will compare blood samples from 176 patients, half taking the drug and half not…

This study aims to create an artificial intelligence (AI) tool to help doctors make better decisions about heart procedures for patients who have both coronary artery disease and a rare bleeding disorder called immune thrombocytopenia (ITP). Researchers will look back at past pat…

This study aims to see if two simple blood measurements—platelet size and an inflammation index—can help doctors better diagnose heart attacks and predict which patients are at higher risk for complications. Researchers will enroll 300 adults who arrive at the hospital with sympt…

This study aims to understand a specific, fast-worsening type of heart artery disease (R-CAD) that doesn't respond well to standard treatments. Researchers will compare about 52 patients—some with this rapid form and some with the more common, slower form—by looking at their medi…