CORONARY ARTERY DISEASE

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard statin therapy can stabilize artery plaques in 212 people who recently had a heart attack. Participants will receive either the added drug or standard care for 6 months, and doctors…

This study tests a special balloon that uses sound waves to break up hard calcium deposits in heart arteries. It involves 200 adults with severe blockages. The goal is to see if this approach safely improves blood flow and lowers the risk of heart attacks or death.

This study looks at people with a completely blocked heart artery (chronic total occlusion) to see if placing a drug-coated stent is better than using only medications over at least 10 years. About 840 participants will be randomly assigned to one of the two treatments. The main …

This study compares two treatments for blocked small heart arteries: paclitaxel-coated balloons and drug-eluting stents. About 1,380 adults with stable or unstable chest pain will be randomly assigned to one of these options. The goal is to see which works better at preventing he…

This study tests whether an early invasive approach (angiogram and possible stenting) plus medication is better than medication alone for people with high-risk coronary plaques found on a CT scan. About 2,500 participants will be followed for 3 years to see which group has fewer …

This study looks at whether people with atrial fibrillation (AF) and prior heart stents can safely stop taking blood thinners if their heart rhythm stays normal for at least a year after AF ablation. Participants will either continue blood thinners or switch to a single antiplate…

This study compares the safety of the drug flecainide to standard rhythm-control medications (sotalol or amiodarone) in 988 adults with atrial fibrillation and stable coronary artery disease. Participants are randomly assigned to one treatment and followed for at least a year to …

This study compares two methods to prepare severely calcified heart arteries before placing a stent: a shockwave device that breaks up calcium versus standard balloon treatment. It also tests whether using a special imaging catheter inside the artery or standard X-ray leads to be…

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus stent in about 2,000 people with coronary artery disease who need a procedure to open blocked heart arteries. The goal is to see if the new stent works just as well at p…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed to open blocked arteries in people with coronary artery disease. About 1,859 participants will receive either the dissolving stent or a standard permanent stent. The goa…

This study compares two methods of preparing a blocked heart stent before using a drug-coated balloon to reopen it. About 500 adults with a re-blocked stent will be randomly assigned to either aggressive balloon preparation (using cutting or scoring balloons) or standard balloon …

This study tests if a drug-coated balloon is as safe and effective as a drug-coated stent for treating large blockages in heart arteries. About 2,492 adults with coronary artery disease will be randomly assigned to one of the two treatments. Doctors will use special imaging to gu…

This study tests two medical devices (Amplatzer Amulet and LAmbre) that close a small pouch in the heart to lower stroke risk in people with an irregular heartbeat (atrial fibrillation) who are at high risk for bleeding. About 200 participants will be randomly assigned to receive…

This pilot study will test whether it is possible to run a larger trial comparing low-dose aspirin to no aspirin in people who have early signs of coronary artery disease but no symptoms. The study will enroll 48 participants and focus on how many people can be recruited and how …

This study tests if a special thinner tube (6-French Glidesheath Slender) can make heart procedures safer and more effective for people with small blood vessels. About 594 adults with coronary artery disease will be randomly assigned to receive the procedure through the wrist usi…

This study compares a new temporary heart pump, the Supira System, to an existing pump (Impella) in 358 people undergoing high-risk heart procedures. The goal is to see if the new pump reduces complications like death, heart attack, stroke, or kidney injury. Participants must be …

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study tests whether a HUAWEI smartwatch with artificial intelligence can improve monitoring and management of heart attack patients during a 3-month outpatient rehab program. About 1,050 adults aged 18-69 who recently had a heart attack and a stent placed will be split into …

This study tests whether a robotic system can safely and effectively assist doctors during a common heart procedure to open blocked arteries. About 170 adults with coronary artery disease will be randomly assigned to receive the procedure with the robot or by a human alone. The g…

This study tests an experimental drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants will receive either YN001 or a placebo by IV, alongside their usual heart medications. The main goal is to see if YN001 reduces non-calc…

This study looks at 300 people having heart bypass surgery to find the best length of time to take two blood thinners (ticagrelor plus aspirin) to keep the new vein grafts open. Participants will take the combination for 3, 6, or 12 months, then switch to aspirin alone. The goal …

This study looks at people who had a heart attack and received a stent. It compares different combinations of blood thinners and cholesterol drugs to find the safest and most effective way to prevent future heart problems while reducing side effects like bleeding. About 4,400 adu…

This study compares two treatments for people with heart failure and a weak heart pump (ejection fraction 40% or less) caused by blocked arteries. One group gets heart stents plus standard medications, the other gets medications alone. The goal is to see which approach better pre…

This study will follow about 50 adults who received a special drug-coated stent (ABLUMINUS NP) to treat blocked heart arteries. Researchers want to see how safe and effective the stent is in real-world use over 5 years. The main goal is to check if the treated artery stays open a…

This study looks at 140 people with coronary artery disease who need non-emergency non-cardiac surgery. Researchers want to see if it is safer and more effective to treat blocked heart arteries before or after the surgery. The goal is to reduce major heart problems like heart att…

This study compares two ways to reroute blood flow around blocked heart arteries during bypass surgery. One method uses only arteries, the other uses a mix of artery and vein grafts. Researchers will check which approach keeps the new blood vessels open better one year after surg…

This study compares two treatments for coronary artery disease: a drug-coated balloon and a drug-coated stent. The goal is to see which works better for patients who have a high risk of bleeding and need a simpler procedure. About 470,000 adults will be followed to check for majo…

This study will test a new type of CT scanner that uses silicon detectors to take clearer pictures of the heart's arteries. The goal is to see if it can provide better image quality while using less radiation compared to current standard CT scanners. About 1,000 adults who are al…

This study aims to see if a single-lead electrocardiogram (ECG) analyzed by machine learning can accurately screen for heart conditions and related diseases like high blood pressure, diabetes, and kidney disease. Researchers will enroll at least 5,000 adults who have already had …

This study tests whether an artificial intelligence (AI) tool can help emergency doctors better interpret heart CT scans in patients with chest pain. About 530 adults at intermediate risk for heart attack will be randomly assigned to have their scans read with or without AI assis…

This study looks at whether using a special heart scan (coronary CTA) combined with a blood flow analysis (CT-FFR) helps doctors make better decisions for people with chest pain who are at moderate risk. About 2,000 participants will be randomly assigned to get this new imaging a…

This study is testing a new digital stethoscope that listens to heart sounds to find early signs of heart disease. Researchers will collect heart sounds from 500 adults who are already having standard heart scans. The goal is to see if this simple, non-invasive device can detect …

This study will check if two blood markers, MPV and SIRI, can help doctors diagnose and predict the course of acute coronary syndrome (heart attack or unstable angina). Researchers will measure these markers in 300 adults admitted within 24 hours of symptoms. The goal is to see i…

This study tests if a numbing injection near certain neck nerves, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (an irregular heartbeat). About 450 adults having bypass surgery will be randomly assigned to get either the nerv…

This study tests whether using a special heart CT scan to guide intensive treatment can reduce major heart problems like heart attacks and strokes compared to standard care. About 15,000 high-risk adults aged 40-75 in rural China will take part. The goal is to see if this persona…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, lower stress, and reduce hospital readmissions. About 70 adults will take part, comparing coaching plus st…

This study tests a program that combines in-person teaching, motivational talks, and a mobile app (LINE) to help older adults in Thailand recover after a heart attack. The goal is to improve healthy habits, well-being, and satisfaction with care. 80 people aged 60 and older who h…

This study tests a new nursing program to help patients and their caregivers adapt after heart bypass surgery. About 40 adults who had the surgery and are recovering at home will take part. The program focuses on improving physical and emotional well-being, and the study will com…

This study looks at a small metal device placed in a heart vein to help people with severe, ongoing chest pain from advanced coronary artery disease who cannot have standard treatments. Researchers will check if the device improves blood flow and reduces daily chest pain episodes…

This study tests whether a personalized, AI-generated video (using a nurse avatar) can improve recovery for 128 adults after coronary artery bypass surgery. Patients will receive either standard discharge instructions or the AI-enhanced version. Researchers will measure pain, anx…

This study looks at whether listening to guided meditation audio can lower stress and anxiety in people having open-heart surgery. About 72 adults will either get the meditation sessions plus standard care, or standard care alone. Researchers will measure stress hormones, blood s…

This study tests whether watching a virtual reality simulation of a cardiac catheterization before the procedure can reduce anxiety and improve satisfaction. About 120 adults having their first heart catheterization in Oman will be randomly assigned to either the VR experience or…

This study looks at how three common treatments for coronary artery disease—surgery, stents, or medication—affect kidney function over the long term. Researchers will follow 1,700 patients for at least 5 years, measuring kidney health through annual blood tests. The goal is to he…

This study will test a new type of CT scanner (photon counting CT) to see if it can give clearer pictures of fatty or calcified plaques in heart arteries. Researchers want to know if these detailed images can help predict who might have a heart attack, stroke, or need a procedure…

This study looks at why some people's coronary artery disease gets worse quickly while others' does not. Researchers will compare medical history, test results, and imaging from 52 adults who have had heart procedures. The goal is to find patterns that could help predict and mana…

This study compares two ways of making treatment decisions for people with severe blockages in all three main heart arteries who also have diabetes. One group gets a real-time online discussion among heart specialists during their procedure, while the other gets usual care. The g…

This study observes 30 adults in Mexico who are already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans, heart CT scans, and body composition tests to see how the drug affects knee cartilage, heart fat, and overall body health over one y…

This study will see if an artificial intelligence program called CaRi-Heart can find inflammation in heart arteries from standard CT scans. Researchers want to know if this extra information helps doctors make better treatment decisions, like starting medications or referring to …

This study will follow 1,000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and instead receive a complex angioplasty (PCI). Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affe…

This study compares two imaging methods (CT-FFR and QFR) to help doctors decide the best treatment for people with coronary artery disease. About 1,400 adults with narrowed heart arteries will be randomly assigned to one of the two imaging-guided strategies. The goal is to see wh…

This study is a nationwide research project in China that will use special cameras inside blood vessels to study hard, bony-like plaques called calcified nodules in heart arteries. These plaques can cause sudden heart attacks and are hard to treat. By watching 500 patients over t…

This study looks at 600 people with coronary artery disease to see if the type of plaque (fatty, scarred, or calcified) seen on a special imaging test called OCT before balloon angioplasty can predict future heart problems. The goal is to understand if knowing the plaque type hel…

This study looks at whether it's safe and better for patients to eat and drink normally before an elective heart catheterization, instead of fasting. About 2000 adults will be randomly assigned to either fast or eat as they wish before the procedure. Researchers will compare how …

This pilot study explores whether transferring gut bacteria from a healthy donor (via fecal transplant) can change the gut microbiome in 30 adults with type 2 diabetes and stable coronary artery disease. The main goal is to see if the microbiome changes after 6 months, not to pro…

This study will test a computer program designed to help doctors make better decisions when treating patients with high cholesterol and related heart risks. Researchers will compare the program's recommendations to what doctors actually prescribed for 500 patients. The goal is to…

This study tests whether using very low radiation doses combined with special image-enhancing software can produce clear pictures of the heart's arteries. About 50 adults scheduled for a standard heart catheterization will have extra images taken with the new low-radiation method…

This study looks at how a low dose of colchicine changes proteins in the blood of people with coronary heart disease who have high inflammation. Researchers want to find new markers and targets for treatment. About 176 patients who had a heart procedure will take colchicine or no…

This study will observe about 1,010 minority patients with complex coronary artery disease who undergo a heart procedure called PCI guided by a special ultrasound (IVUS). The goal is to see if this imaging technique helps reduce heart-related complications like death or heart att…

This study will follow 5,000 adults with coronary artery disease who receive a drug-coated balloon treatment to open blocked heart arteries. Researchers want to see how well the treatment works over the long term and track any complications like heart attacks or repeat procedures…

This study looks at whether a simple ultrasound test can help predict how well people recover after a stroke caused by a large blood clot. Researchers will measure blood flow in the brain using transcranial Doppler (TCD) ultrasound in 100 adults who had a stroke and received endo…

This study compares mild hypothermia (33-34°C) to normal body temperature (36.5°C) during heart bypass surgery to see which better protects the brain. Researchers will use advanced MRI scans and blood tests to measure brain injury in 160 adults undergoing coronary artery bypass g…

This study will develop an artificial intelligence (AI) tool to help doctors decide the best heart treatment for people who have both immune thrombocytopenia (ITP) and coronary artery disease. Researchers will analyze data from 600 patients to predict the risk of major heart prob…

This study will test if sending an electronic letter to 100,000 adults in Denmark with heart disease and high cholesterol encourages them to get their cholesterol checked. Some participants will also receive extra information about a related risk factor. The goal is to see if sim…

This study involves 800 elderly patients (70 years or older) with heart artery disease. Researchers will use CT scans, frailty assessments, and blood tests to create a model that predicts the risk of major heart events over two years. The goal is to improve treatment decisions fo…

This study is testing a new computer-based decision aid designed to help cancer survivors and their heart doctors. The tool, accessed through electronic health records, aims to improve decisions about heart-protective medications and monitoring tests. Researchers want to see if b…