Heart attack prevention: should doctors stent dangerous plaques early?

NCT ID NCT07569692

Not yet recruiting Disease control Sponsor: Seung-Jung Park Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether an early, aggressive approach—using a catheter to open and stent high-risk plaques seen on a CT scan—plus medication is better than medication alone for preventing heart problems. About 2,500 people with coronary artery disease will be randomly assigned to one of the two strategies. The goal is to see which approach reduces deaths, heart attacks, and hospitalizations over three years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: invasive coronary angiography with preventive percutaneous coronary intervention (PCI) plus optimal medical therapy
What this could lead to: If successful, this could show that early, preventive stenting of high-risk plaques reduces heart attacks and hospitalizations compared to medication alone.
What could go wrong: This is a large trial but has not yet started recruiting. The invasive procedure carries risks like bleeding or vessel damage, and the benefit over medication alone is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

Asan Medical Center

Seoul, South Korea

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