Could CO2 replace dye for heart scans? new study investigates

NCT ID NCT06253884

Not yet recruiting Diagnosis Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to check if the method is safe, tolerable, and technically feasible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carbon dioxide (CO2) gas delivered via RespirAct device
What this could lead to: If successful, this could lead to a safer, contrast-free way to diagnose blocked arteries in the heart using just CO2 and MRI.
What could go wrong: This is a very early pilot study with only 30 people, so it may not work as hoped or be widely usable. The approach is still experimental and needs much more testing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States

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