Heart pump may protect patients during risky stent procedures

NCT ID NCT05003817

Ongoing Disease control Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a temporary heart pump can help high-risk patients during coronary stenting. The pump supports the heart's main chamber during the procedure, aiming to prevent heart failure or death. About 300 patients with severe coronary disease and weak heart muscle will be randomly assigned to receive the pump or standard care. The trial will compare rates of death, stroke, heart attack, and hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: percutaneous left ventricular unloading device (a temporary heart pump)
What this could lead to: If it works, this could provide a safer way to perform stenting in high-risk patients, reducing serious complications like heart failure or death.
What could go wrong: This is a Phase 3 trial, but the device itself carries risks like bleeding or leg artery damage, and it is expensive. The benefit over standard care is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE ISCHEMIC HEART DISEASE

Contacts and locations

Locations

Guy's and St Thomas' NHS Foundation Trust

London, SE1 7EH, United Kingdom

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