Lifestyle overhaul may ease chest pain in hidden heart disease
NCT ID NCT06025994
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tests whether a multi-domain lifestyle program—including diet, exercise, stress management, and tailored medication—can reduce chest pain and improve quality of life in people with coronary microvascular dysfunction (small vessel heart disease). About 120 patients will be randomly assigned to the lifestyle program or standard care and followed for up to 5 years. The main goal is to see if angina symptoms improve after one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- multi-domain lifestyle intervention (diet, exercise, risk management, tailored medication, psychological support)
- What this could lead to
- If successful, this could show that a comprehensive lifestyle program improves chest pain and quality of life for people with microvascular heart disease.
- What could go wrong
- This is a relatively small, open-label trial (no placebo), so results may be influenced by patient expectations. The intervention is complex and may be hard to replicate in routine care.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AOU Ferrara
Ferrara, Ferrara, 44124, Italy
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AOU di Parma
Parma, Parma, Italy
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