Experimental antibody cocktail takes on Hard-to-Treat myeloma

NCT ID NCT06669247

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests a new experimental drug, REGN7945, combined with another experimental drug, linvoseltamab, in people with multiple myeloma that has returned or not responded to at least three prior treatments. The goal is to see if the combination is safe and can shrink tumors better than linvoseltamab alone. About 186 participants will take part in this first-in-human trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: REGN7945 (an experimental immune-boosting antibody) combined with linvoseltamab (another experimental antibody)
What this could lead to: If successful, this combination could offer a new treatment option for people with multiple myeloma that has stopped responding to other therapies.
What could go wrong: This is an early, first-in-human trial, so safety and effectiveness are not yet known. Side effects may occur, and the combination may not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY MULTIPLE MYELOMA

Contacts and locations

Locations

Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
Illawarra Cancer Care Centre
RECRUITING

Wollongong, New South Wales, 2500, Australia
Pindara Private Hospital
RECRUITING

Benowa, Queensland, 4217, Australia
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Prince Alfred Hospital
RECRUITING

Sydney, New South Wales, 2050, Australia
St Thomas Hospital
RECRUITING

London, SE1 7EH, United Kingdom
St Vincents Hospital Melbourne
RECRUITING

Melbourne, Victoria, 3065, Australia
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BQ, United Kingdom
University College London Hospitals
RECRUITING

London, NW1 2PG, United Kingdom

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