New combo therapy aims to tackle Tough-to-Treat myeloma

NCT ID NCT05137054

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tests an experimental drug called linvoseltamab combined with other cancer treatments for people with multiple myeloma that has come back after previous therapy. The main goal is to see if the combinations are safe and to find the right dose. About 317 participants will be enrolled, and researchers will also check if the tumors shrink or disappear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: linvoseltamab (also called REGN5458) plus other cancer drugs (daratumumab, carfilzomib, lenalidomide, bortezomib)
What this could lead to: If successful, this could lead to a new combination treatment option for patients with multiple myeloma that has returned after prior therapies.
What could go wrong: This is an early Phase 1b study focused on safety and dosing, so it is too soon to know if the combinations will work. Side effects from the drugs are possible, and the trial is small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

CHU Montpellier - Departement D'Hematologie
RECRUITING

Montpellier, 34295, France
CHU de Lille - Rue Michel Polonovski
SUSPENDED

Lille, Nord, 59037, France
Centre Hospitalier Universitaire (CHU) de Poitiers
RECRUITING

Poitiers, New Aquitaine, 86021, France
Centre Hospitalier Universitaire Angers
RECRUITING

Angers, 49933, France
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinica Universidad de Navarra - Madrid
RECRUITING

Madrid, 28027, Spain
Dana Farber/Harvard Cancer Center
RECRUITING

Boston, Massachusetts, 02215, United States
Evangelismos General Hospital
RECRUITING

Athens, Attica, 10676, Greece
General Hospital of Athens Alexandra
RECRUITING

Athens, 11528, Greece
Hadassah Medical Center
RECRUITING

Jerusalem, 91120, Israel
Hopital Necker
RECRUITING

Paris, Île-de-France Region, 75015, France
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Santiago
RECRUITING

Santiago de Compostela, A Coruna, 15706, Spain
Hospital Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 08916, Spain
Hospital Henri Mondor
RECRUITING

Créteil, Île-de-France Region, 94000, France
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Quiron Salud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Ramon y Cajal - Servicio de Psiquiatria
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Indiana University Health Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Institut Catala d'Oncologia (ICO) - Hospital Duran i Reynals,
RECRUITING

Barcelona, 08908, Spain
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Nantes University Hospital
RECRUITING

Nantes, Pays de la Loire Region, 44093, France
New York Presbyterian Hospital Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
Saint Antoine Hospital
RECRUITING

Paris, 75571, France
Saint Louis Hospital
RECRUITING

Paris, Île-de-France Region, 75010, France
Scripps Clinic Torrey Pines
RECRUITING

La Jolla, California, 92037, United States
Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5265601, Israel
The Ohio State University James Cancer Hospital
RECRUITING

Columbus, Ohio, 43210, United States
Universitaru Hospital La Princesa
RECRUITING

Madrid, 28006, Spain
University Hospital and Research Institute
RECRUITING

Madrid, 28041, Spain
University Hospital of Salamanca
RECRUITING

Salamanca, 37007, Spain
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States
VA Puget Sound Health Care System
RECRUITING

Seattle, Washington, 98108, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Weill Cornell Medicine/New York Presbyterian Hospital
RECRUITING

New York, New York, 10021, United States
Winship Cancer Institute of Emory University
RECRUITING

Atlanta, Georgia, 30004, United States

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