New drug duo aims to rescue PNH patients failing standard care
NCT ID NCT07154745
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two experimental drugs, pozelimab and cemdisiran, together in 35 adults with paroxysmal nocturnal hemoglobinuria (PNH) whose red blood cell destruction is not well-controlled by current C5 inhibitors. The goal is to see if the combination can lower hemolysis (breakdown of red blood cells) better than existing treatments. Participants will receive the drugs by injection and be monitored for side effects and blood levels.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AOU Careggi
RECRUITINGFlorence, Tuscany, 50134, Italy
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Ege University
RECRUITINGIzmir, 35100, Turkey (Türkiye)
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Ewha Womans University Mokdong Hospital
RECRUITINGSeoul, 07985, South Korea
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Hospital General JM Morales Meseguer
RECRUITINGMurcia, 30008, Spain
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Hospital San Pedro de Alcantara
RECRUITINGCáceres, 10003, Spain
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Hospital Universitario Basurto
RECRUITINGBilbao, Vizcaya, 48013, Spain
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Hospital Universitario de Salamanca
RECRUITINGSalamanca, 37007, Spain
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Hospital das Clinicas da FMRP USP
RECRUITINGRibeirão Preto, São Paulo, 14051-260, Brazil
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In-Vivo Sp. z o.o.
RECRUITINGBydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-048, Poland
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Istanbul University Istanbul Faculty of Medicine
RECRUITINGIstanbul, 34418, Turkey (Türkiye)
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SC Hematology, AOU Città della Salute e della Scienza di Torino
RECRUITINGTorino, 10126, Italy
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Samsung Medical Center
RECRUITINGSeoul, 6351, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Seoul St. Mary's Hospital - The Catholic University of Korea
RECRUITINGSeoul, 065791, South Korea
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Severance Hospital
RECRUITINGSeoul, 03722, South Korea
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Universita Cattolica del Sacro Cuore - Policlinico Universitario A. Gemelli
RECRUITINGRome, Lazio, 00168, Italy