New drug linvoseltamab takes on multiple myeloma in early trial

NCT ID NCT05828511

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called linvoseltamab in people newly diagnosed with multiple myeloma, a type of blood cancer. The drug is designed to help the immune system attack cancer cells. The trial will check for side effects and see if the drug can shrink tumors. About 149 participants will take part, some before and after a stem cell transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: linvoseltamab (a bispecific antibody that targets BCMA on myeloma cells and CD3 on immune cells)
What this could lead to: If successful, this could provide a new treatment option for newly diagnosed multiple myeloma, potentially improving response rates and depth of remission.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so safety and effectiveness are not yet proven. Side effects, including immune reactions, are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

CHU De Lille
NOT_YET_RECRUITING

Lille, 59000, France
Centre Hospitalier Universitaire (CHU) Montpellier
RECRUITING

Montpellier, 342950, France
Centre Hospitalier Universitaire (CHU) de Poitiers
RECRUITING

Poitiers, Vienne, 86021, France
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinica Universidad de Navarra - Madrid
RECRUITING

Madrid, 28027, Spain
Colorado Blood Cancer Institute/SCRI
RECRUITING

Denver, Colorado, 80218, United States
Columbia University _ New York Presbyterian
RECRUITING

New York, New York, 10032, United States
Duke University Health System (DUHS)
RECRUITING

Durham, North Carolina, 27705, United States
Gustave Roussy
RECRUITING

Villejuif, Île-de-France Region, 94800, France
Hopital Necker
RECRUITING

Paris, Île-de-France Region, 75015, France
Hopital Prive d'Antony
RECRUITING

Antony, Île-de-France Region, 92160, France
Hopital Saint Louis
RECRUITING

Paris, 75010, France
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Doctor Balmis Alicante
RECRUITING

Alicante, Valencia, 03010, Spain
Hospital Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 08916, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Quiron Salud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Institut Catala dOncologia (ICO Hospitalet)
RECRUITING

Barcelona, 08908, Spain
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UC Irvine Health
RECRUITING

Orange, California, 92868, United States
Universitary Hospital La Princesa
RECRUITING

Madrid, 28006, Spain
University Hospitals Pitie Salpetriere - Charles Foix
RECRUITING

Paris, 75651, France
University of California Los Angeles (UCLA)
RECRUITING

Los Angeles, California, 90095, United States

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