Can a drug nip myeloma in the bud? new trial aims to stop cancer before it starts

NCT ID NCT06140524

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This Phase 2 trial is testing an investigational drug called linvoseltamab in 116 people with precancerous blood conditions that raise their risk of developing multiple myeloma. The goal is to see if the drug can eliminate abnormal plasma cells and lab signs of disease. Researchers will also monitor side effects and how the drug behaves in the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: linvoseltamab (a drug given by injection)
What this could lead to: If it works, this could point toward a way to stop precancerous conditions from turning into multiple myeloma, potentially preventing the disease.
What could go wrong: This is an early Phase 2 study with only 116 participants, so results may not apply to everyone. The drug may cause side effects, and it is not yet proven to prevent cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

monoclonal gammopathy of uncertain significance Smoldering Multiple Myeloma smoldering plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) SMOLDERING MULTIPLE MYELOMA (SMM)

Contacts and locations

Locations

AZ Sint Maarten Algemeen Ziekenhuis Emmaus
RECRUITING

Mechelen, Flanders, 2800, Belgium
AZ St.-Elisabeth Herentals vzw
RECRUITING

Herentals, Antwerp, 2200, Belgium
Algemeen Ziekenhuis (AZ) Klina
RECRUITING

Brasschaat, Antwerpen, 2930, Belgium
Algemeen Ziekenhuis AZ Delta
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
Algemeen Ziekenhuis St Jan Brugge Oostende Av
RECRUITING

Bruges, West-Vlaanderen, 8000, Belgium
Azienda Ospedaliero Universitaria (AOU) SS. Antonio e Biagio e Cesare Arrigo
RECRUITING

Alessandria, Piedmont, 15121, Italy
Centre Hospitalier Universitaire De Poitiers
RECRUITING

Poitiers, New Aquitaine, 86000, France
Cork University Hospital
RECRUITING

Cork, T12 EC8P, Ireland
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Galway University Hospital
RECRUITING

Galway, Connacht, H91 YR71, Ireland
Hospital Clinico Universitario Virgen De La Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
Hospital General Universitario Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hospital Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hospital Universitari Mutua Terrassa
RECRUITING

Terrassa, Barcelona, 08221, Spain
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Andalusia, 18014, Spain
Hospital de Cabuenes
RECRUITING

Gijón, Principality of Asturias, 33203, Spain
IRCCS Ospedale Policlinico San Martino
RECRUITING

Genoa, Genova, 16132, Italy
Institut Catala dOncologia (ICO Hospitalet)
RECRUITING

Barcelona, 08908, Spain
Institut Curie
RECRUITING

Paris, Île-de-France Region, 75005, France
Istituto Romagnolo per lo Studio Dei Tumori Dino Amadori
RECRUITING

Meldola, Forli-Cesena, 47014, Italy
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Mater Misericordiae University Hospital
RECRUITING

Dublin, D07 R2WY, Ireland
NYU Langone Health Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, 48121, Italy
Pratia MCM Krakow
RECRUITING

Krakow, Malopolska, 30-510, Poland
San Paolo Hospital
RECRUITING

Milan, Lombardy, 20142, Italy
Specjalistyczny Szpital im A. Sokolowskiego w Walbrzychu
RECRUITING

Wałbrzych, Lower Silesian Voivodeship, 58-309, Poland
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
Swietokrzyskie Centrum Onkologii
RECRUITING

Kielce, Świętokrzyskie Voivodeship, 25-734, Poland
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UOC Ematologia e Terapia Cellulare - PO Mazzoni AST Ascoli Piceno
RECRUITING

Ascoli Piceno, 63100, Italy
Universita degli Studi di Pavia - Fondazione IRCCS Policlini
RECRUITING

Pavia, 27100, Italy
Universitaru Hospital La Princesa
RECRUITING

Madrid, 28006, Spain
University Clinical Center / Medical University of Gdansk
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-219, Poland
University of Michigan Health
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Washington
RECRUITING

Seattle, Washington, 98109, United States
Wojewodzki Szpital Zespolony - Ludwik Rydygier Provincial Hospital
RECRUITING

Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. Mikolaja Kopernika w Lodzi (Copernicus Memorial Hospital)
RECRUITING

Lodz, 93-513, Poland
Ziekenhuis Netwerk Antwerpen Cadix, Hematology
RECRUITING

Antwerp, 2030, Belgium

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