New drug aims to outperform chemo for common lymphoma

NCT ID NCT06091254

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This phase 3 trial tests an experimental drug called odronextamab for people with previously untreated follicular lymphoma, a slow-growing blood cancer. The study compares odronextamab alone or with standard chemotherapy to see if it leads to better remission rates. About 822 participants will be enrolled across two parts: first to check safety, then to measure effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: odronextamab (a bispecific antibody that helps immune cells attack cancer)
What this could lead to: If it works, this could offer a new first-line treatment option for follicular lymphoma that may be more effective than current standard chemo.
What could go wrong: This is a large phase 3 trial, but odronextamab is still experimental. Side effects like cytokine release syndrome are possible, and it may not prove superior to existing therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOLLICULAR LYMPHOMA (FL)

Contacts and locations

Locations

AC Camargo Cancer Center
RECRUITING

São Paulo, 01509010, Brazil
AOU Maggiore della Carita-SCDU Ematologia
RECRUITING

Novara, 28100, Italy
AZ St.-Elisabeth Herentals vzw
WITHDRAWN

Herentals, Antwerp, 2200, Belgium
Aidport
RECRUITING

Skorzewo, Wielkopolska, 60185, Poland
Ajou University Hospital
RECRUITING

Suwon, Gyeonggi-do, 16499, South Korea
Alfred Hospital and Monash University
RECRUITING

Melbourne, Victoria, 3004, Australia
Amaral Carvalho Hospital
RECRUITING

Jaú, São Paulo, 17210080, Brazil
Animi Unidade de Tratamento Oncologico Ltda
RECRUITING

Lages, Santa Catarina, 88501-001, Brazil
Ankara University Faculty of Medicine
WITHDRAWN

Mamak, Ankara, 06620, Turkey (Türkiye)
Azienda Ospedaliera Spedali Civili di Brescia
RECRUITING

Brescia, 25123, Italy
Barking, Havering and Redbridge University Hospitals NHS Trust
RECRUITING

Romford, RM7 0AG, United Kingdom
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, Lanarkshire, G12 0YN, United Kingdom
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Bnai Zion Medical Center
RECRUITING

Haifa, 31048, Israel
CHU de Quebec - Universite Laval
RECRUITING

Québec, Quebec, G1J1Z4, Canada
Candiolo Cancer Institute, FPO, IRCCS
RECRUITING

Candiolo, Torino, 10060, Italy
Cantonal Hospital St Gallen
RECRUITING

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
Casa de Saude Santa Marcelina
RECRUITING

São Paulo, 08270-070, Brazil
Center for Hematologic Malignancy
WITHDRAWN

Goyang-si, Gyeonggi-do, 10408, South Korea
Center for Oncology and Blood Disorders
RECRUITING

Houston, Texas, 77030, United States
Centre Hospitalier Regional Universitaire de Tours
RECRUITING

Tours, Centre-Val de Loire, 37044, France
Centre Hospitalier Universitaire (CHU) Rennes
RECRUITING

Rennes, Brittany Region, 35033, France
Centre Hospitalier Universitaire (CHU) de Poitiers
WITHDRAWN

Poitiers, Vienne, 86021, France
Centre Hospitalier Universitaire Angers
RECRUITING

Angers, 49933, France
Centre Integre de Sante et de Services Sociaux (CISSS) de la Monteregie-Centre
RECRUITING

Greenfield Park, Quebec, J4V 2H1, Canada
Centro Oncologia de Precision Universidad Mayor
WITHDRAWN

Santiago, Santiago Metropolitan, 7560907, Chile
Centro de Hematologia e Oncologia
RECRUITING

Joinville, Santa Catarina, 89201260, Brazil
Centrum Innowacyjnych Terapii Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
RECRUITING

Lublin, 20-954, Poland
Chaim Sheba Medical Center
RECRUITING

Ramat Gan, 5265601, Israel
Chang Gung Medical Foundation Chia Yi Branch
WITHDRAWN

Buzi, Chiayi County, 613, Taiwan
Chang Gung Memorial Hospital Linkou
RECRUITING

Taoyuan City, Guishan District, 333, Taiwan
Changhua Christian Hospital
RECRUITING

Changhua, 500-06, Taiwan
Charite Universitatsmedizin Berlin Campus Benjamin Franklin
RECRUITING

Berlin, 12203, Germany
Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Ciusss de Lestrie - Centre Hospitalier Universitaire de Sherbrooke (CHUS)
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Clinic Frankfurt (Oder)
WITHDRAWN

Frankfurt am Main, Hesse, 15236, Germany
Clinica Alemana de Santiago
RECRUITING

Santiago, Santiago Metropolitan, 7650620, Chile
Clinica Universidad de Navarra
WITHDRAWN

Madrid, 28027, Spain
Clinica Universidad de Navarra
RECRUITING

Madrid, 28027, Spain
Clinical Hospital of Medicine School at Sao Paulo University
RECRUITING

São Paulo, 05403-000, Brazil
Clinical Research Alliance Inc
WITHDRAWN

Westbury, New York, 11590, United States
Cm Pratia Poznan
COMPLETED

Skorzewo, Wielkopolska, 60185, Poland
Complejo Hospitalario Universitario de a Coruna
WITHDRAWN

A Coruña, Galicia, 15006, Spain
Complexo Hospitalario Universitario de Ourense
WITHDRAWN

Ourense, 32005, Spain
Copernicus Memorial Hospital
WITHDRAWN

Lodz, 93-513, Poland
Cruces University Hospital (Hospital Universitario Cruces)
RECRUITING

Barakaldo, Bizkaia, 48903, Spain
David Geffen School of Medicine at UCLA
RECRUITING

Los Angeles, California, 90095, United States
Derriford Hospital and the Royal Eye Infirmary
WITHDRAWN

Plymouth, Devon, PL6 8DH, United Kingdom
Dong-A University Hospital
COMPLETED

Busan, 49201, South Korea
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING

Yenimahalle, Ankara, 06200, Turkey (Türkiye)
Ege University
RECRUITING

Izmir, 35100, Turkey (Türkiye)
Ensino e Terapia de Inovacao Clinica Amo (Etica)
RECRUITING

Salvador, Estado de Bahia, 41950640, Brazil
Epworth Freemasons
RECRUITING

East Melbourne, Victoria, 3121, Australia
Erci̇yes Uni̇versi̇ty
RECRUITING

Kayseri, 38039, Turkey (Türkiye)
Federico II University
COMPLETED

Naples, 80131, Italy
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Fundacao Pio XII Hospital de Amor
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Fundacion Arturo Lopez Perez
RECRUITING

Santiago, Santiago Metropolitan, 7500921, Chile
Fundacion Jimenez Diaz University Hospital
RECRUITING

Madrid, 28040, Spain
Galilee Medical Center
RECRUITING

Nahariya, 2210001, Israel
Gazi University
RECRUITING

Ankara, Central Anatolia, 06100, Turkey (Türkiye)
Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Gustave Roussy
RECRUITING

Villejuif, Île-de-France Region, 94800, France
HOPE Cancer Center of East Texas
WITHDRAWN

Tyler, Texas, 75701, United States
Hadassah Medical Center
RECRUITING

Jerusalem, 91200, Israel
Hanusch Krankenhaus
RECRUITING

Vienna, 1140, Austria
Hattiesburg Clinic
COMPLETED

Hattiesburg, Mississippi, 39401, United States
Hematological Praxis Dresden
RECRUITING

Dresden, Saxony, 01307, Germany
Hopital De Jolimont
WITHDRAWN

La Louvière, Hainaut, 7100, Belgium
Hopital Saint Louis
RECRUITING

Paris, 75010, France
Hopital Saint-Antoine
RECRUITING

Paris, 755710, France
Hopital Victor Dupouy Argenteuil
RECRUITING

Argenteuil, Île-de-France Region, 95100, France
Hopital de la Conception
RECRUITING

Marseille, Provence-Alpes-Côte d'Azur Region, 13005, France
Hospital Alemao Oswaldo Cruz
RECRUITING

São Paulo, 01323-903, Brazil
Hospital Clinico Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hospital Clinico Universitario Valencia
WITHDRAWN

Valencia, 46010, Spain
Hospital Clinico Universitario Virgen De La Arrixaca
WITHDRAWN

El Palmar, Murcia, 30120, Spain
Hospital General Universitario de Toledo
WITHDRAWN

Toledo, 45007, Spain
Hospital Universitari and Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Central de Asturias
WITHDRAWN

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario HM Sanchinarro, Servicio de Hematologia
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Virgen De La Victoria Malaga
RECRUITING

Málaga, Andalusia, 29010, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Andalusia, 41009, Spain
Hospital Universitario Virgen de Valme
RECRUITING

Seville, 41014, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Hospital Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Virgen De Las Nieves De Granada
RECRUITING

Granada, 18014, Spain
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo
RECRUITING

Ribeirão Preto, São Paulo, 14048-900, Brazil
Hospital de Clinicas de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Huntsman Cancer Institute - Oncology Division
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS Ospedale Policlinico San Martino
RECRUITING

Genoa, Liguria, 16132, Italy
Icahn School of Medicine at Mt Sinai
RECRUITING

New York, New York, 10029, United States
Icon Cancer Centre - Wesley
COMPLETED

Auchenflower, Queensland, 4066, Australia
Ingham Institute
RECRUITING

Liverpool, New South Wales, 2170, Australia
Inmunocel
RECRUITING

Santiago, Santiago Metropolitan, 7580206, Chile
Inselspital Bern University Hospital
RECRUITING

Bern, 3010, Switzerland
Institut Jules Bordet
WITHDRAWN

Brussels, 1000, Belgium
Institut Paoli Calmettes
RECRUITING

Marseille, 13009, France
Institut de Cancerologie Strasbourg Europe (ICANS)
RECRUITING

Strasbourg, 67033, France
Instituto Americas
RECRUITING

Rio de Janeiro, 22793-334, Brazil
Instituto DOr de Pesquisa e Ensino Df Star
RECRUITING

Brasília, 70390-140, Brazil
Instituto Mario Pena de Ensino Pesquisa e Inovacao
RECRUITING

Belo Horizonte, Minas Gerais, 30380-420, Brazil
Instituto Nacional de Cancer Jose Alencar Gomes da Silva
WITHDRAWN

Rio de Janeiro, 20231050, Brazil
Instituto do Cancer em Hospital Sao Vicente de Paulo
RECRUITING

Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
Investigative Clinical Research of Indiana
RECRUITING

Noblesville, Indiana, 46062, United States
Irccs Aou Di Bologna - Policlinico Di Sant'orsola Malpighi
WITHDRAWN

Bologna, 40138, Italy
Istanbul University Istanbul Faculty of Medicine
RECRUITING

Istanbul, 34418, Turkey (Türkiye)
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Romagnolo Per Lo Studio Dei Tumori
RECRUITING

Meldola, Forli Cesena, 47014, Italy
Jeonbuk National University Hospital
WITHDRAWN

Jeonju, Jeollabuk-do, 54907, South Korea
Kantonsspital Baden
RECRUITING

Baden, Canton of Aargau, 5404, Switzerland
Kantonsspital Winterthur Medical Oncology
RECRUITING

Winterthur, Schweiz, 8401, Switzerland
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Kliniken Ostalb Stauferklinikum Schwab Gmund
RECRUITING

Mutlangen, Gmund, D-73557, Germany
Kyungpook National University Chilgok Hospital
WITHDRAWN

Daegu, 41404, South Korea
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28207, United States
Liga Norte Riograndense Contra o Cancer
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Liv Hospital Ankara
WITHDRAWN

Ankara, 06100, Turkey (Türkiye)
Medical University of Vienna
RECRUITING

Vienna, 1090, Austria
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Morales Meseguer Hospital
RECRUITING

Murcia, 30008, Spain
Nantes University Hospital
WITHDRAWN

Nantes, Pays de la Loire Region, 44093, France
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Warszawa
WITHDRAWN

Warsaw, 02781, Poland
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100225, Taiwan
Norfolk and Norwich University Hospital
RECRUITING

Norwich, Norfolk, NR4 7UY, United Kingdom
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
WITHDRAWN

Samsun, 55239, Turkey (Türkiye)
Ordensklinikum Linz
RECRUITING

Linz, Osterreich, 4010, Austria
Ordensklinikum Linz Gmbh, Elisabethinen
RECRUITING

Linz, 4020, Austria
Ospedale dell'Angelo - Varese
RECRUITING

Varese, 21100, Italy
Pia Fondazione Panico
RECRUITING

Tricase, Lecce, 73039, Italy
Pratia MCM Krakow
RECRUITING

Krakow, Malopolska, 30-510, Poland
Pratia Onkologia Katowice
RECRUITING

Katowice, 40-519, Poland
Prohealth Care Inc
WITHDRAWN

Waukesha, Wisconsin, 53188, United States
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Robert-Bosch-Krankenhaus
WITHDRAWN

Stuttgart, Baden-Wurttemberg, 70376, Germany
Royal Cornwall Hospitals NHS Trust, Royal Cornwall Hospital
RECRUITING

Truro, Cornwall, TR1 3LJ, United Kingdom
Saint John Regional Hospital
RECRUITING

Saint John, New Brunswick, E2L 4L2, Canada
Sakarya University Medical Faculty
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Samson Assuta Ashdod University Hospital
RECRUITING

Ashdod, 7747629, Israel
Santa Maria della Misericordia
RECRUITING

Udine, 33100, Italy
Seoul St. Mary's Hospital
WITHDRAWN

Seoul, 06591, South Korea
Son Espases University Hospital
WITHDRAWN

Palma, Balearic Islands, 07120, Spain
Specjalistyczny Szpital im A. Sokolowskiego w Walbrzychu
RECRUITING

Wałbrzych, Lower Silesian Voivodeship, 58-309, Poland
St Vincent's Hospital - Melbourne
RECRUITING

Fitzroy, Victoria, 3065, Australia
St. Vincents Hospital - The Catholic University of Korea
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Stadtisches Krankenhaus Kiel
RECRUITING

Kiel, 24116, Germany
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
Taichung General Veterans Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Medical University-Shuang Ho Hospital
RECRUITING

New Taipei City, 235, Taiwan
Taipei Municipal Wan Fang Hospital
RECRUITING

Taipei, 116, Taiwan
Taipei Veterans General Hospital
COMPLETED

Taipei, 11217, Taiwan
Tekirdag Namik Kemal University Hospital
RECRUITING

Tekirdağ, Suleymanpasa, 59100, Turkey (Türkiye)
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 64239, Israel
Tom Baker Cancer Center
RECRUITING

Calgary, Alberta, T2N 4J8, Canada
Tri-Service General Hospital
RECRUITING

Taipei, 114, Taiwan
UC Irvine Health
WITHDRAWN

Orange, California, 92868, United States
UO Ematologia Ravenna
RECRUITING

Ravenna, 48121, Italy
UOC Ematologia e Terapia Cellulare - PO Mazzoni AST Ascoli Piceno
WITHDRAWN

Ascoli Piceno, 63100, Italy
Uniklinikum Salzburg (LKH) Universitatsklinik fur Innere Medizin III
RECRUITING

Salzburg, 5020, Austria
Universitair Ziekenhuis (UZ) Gent/ Ghent University Hospital
WITHDRAWN

Ghent, Oost-Vlaanderen, 9000, Belgium
Universitatsmedizin der Johannes-Gutenberg Universitat Mainz
RECRUITING

Mainz, Rhineland-Palatinate, 55131, Germany
University Hospital & Research Institute
RECRUITING

Madrid, 28041, Spain
University Hospital Basel
RECRUITING

Basel, 4031, Switzerland
University Hospital Carl Gustav Carus
RECRUITING

Dresden, 01307, Germany
University Hospital Hradec Kralove
RECRUITING

Hradec Králové, 50005, Czechia
University Hospital Kralovske Vinohrady
RECRUITING

Prague, 10034, Czechia
University Hospital Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
University Hospital Virgen del Rocio
RECRUITING

Seville, 41013, Spain
University Hospital Wurzburg
RECRUITING

Würzburg, Bavaria, 97080, Germany
University Hospital of Santiago de Compostela
RECRUITING

Santiago de Compostela, A Coruna, 15706, Spain
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Hospitals Dorset
RECRUITING

Bournemouth, Dorset, BH77DW, United Kingdom
University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85724, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Uniwersytecki Szpital Kliniczny
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-952, Poland
VKV American Hopital
RECRUITING

Istanbul, 34365, Turkey (Türkiye)
VM Medical Park Mersin Hospital
WITHDRAWN

Mezitli, Mersin, 33200, Turkey (Türkiye)
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University
WITHDRAWN

Richmond, Virginia, 23219, United States
Vseobecna Fakultni Nemocnice
RECRUITING

Prague, 12808, Czechia
Ziekenhuis Netwerk Antwerpen Stuivenberg
WITHDRAWN

Antwerp, 2060, Belgium
Zonguldak Bulent Ecevit University
WITHDRAWN

Zonguldak, 67100, Turkey (Türkiye)

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