New shot could replace aspirin to stop clots after knee surgery

NCT ID NCT07213778

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 5 times

Summary

This study tests an experimental drug called REGN7508 (cenvacibart) against aspirin to prevent blood clots in 2000 adults having knee replacement surgery. The drug targets a clotting factor to reduce clot risk. Researchers will compare how many people develop clots or die from clot-related causes in each group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: REGN7508 (cenvacibart), a factor XI monoclonal antibody
What this could lead to: If it works, this could offer a new way to prevent dangerous blood clots after knee replacement surgery with potentially fewer bleeding risks than current options.
What could go wrong: This is a large phase 3 trial, but the drug is still experimental. It may not prove safer or more effective than aspirin, and unexpected side effects or bleeding risks remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism Venous Thrombosis venous thromboembolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYMPTOMATIC VENOUS THROMBOEMBOLISM (VTE)

Contacts and locations

Locations

Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24015, United States
Coastal Vascular Institute, PA
RECRUITING

Wilmington, North Carolina, 28401, United States
Eisenhower Medical Center
RECRUITING

Rancho Mirage, California, 92270, United States
Endeavor Clinical Trials
WITHDRAWN

San Antonio, Texas, 78240, United States
Endeavor Health
RECRUITING

Skokie, Illinois, 60076, United States
Eximia Equihealth Research-Raleigh. LLC
RECRUITING

Raleigh, North Carolina, 27612, United States
Flourish Research - San Antonio (Formerly Clinical Trials of Texas)
RECRUITING

San Antonio, Texas, 78229, United States
HD Research - Memorial Hermann Village
RECRUITING

Houston, Texas, 77043, United States
Henry Dunant Hospital Center
RECRUITING

Athens, Attica, 11526, Greece
Holy Name Medical Center
RECRUITING

Teaneck, New Jersey, 07666, United States
Horizon Clinical Research
RECRUITING

La Mesa, California, 91942, United States
Hospital Tengku Ampuan Afzan (HTTA)
RECRUITING

Kuantan, Pahang, 25100, Malaysia
Medical Research of Westchester - MPLUS Research Network
RECRUITING

Miami, Florida, 33165, United States
NextStage Clinical Research, All American Orthopedics and Sports Medicine
RECRUITING

Houston, Texas, 77058, United States
NextStage Clinical Research, St. Francis Medical Park
RECRUITING

Wichita, Kansas, 67214, United States
Ohio Clinical Trials
RECRUITING

Columbus, Ohio, 43212, United States
PMSI Emergency Medicine Institute
RECRUITING

Chisinau, MD-2004, Moldova
Phoenix Clinical Research
RECRUITING

Tamarac, Florida, 33321, United States
Sinai Hospital of Baltimore, Inc.
RECRUITING

Baltimore, Maryland, 21215, United States
Sky Ridge Medical Center
RECRUITING

Lone Tree, Colorado, 80124, United States
South Florida Joint Replacement Center
RECRUITING

Deerfield Beach, Florida, 33064, United States
Spokane Joint Replacement Center
RECRUITING

Spokane, Washington, 99218, United States
Sultan Abdul Halim Hospital
RECRUITING

Sungai Petani, Kedah, 08000, Malaysia
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The Orthopaedic Research Foundation, Inc.
RECRUITING

Indianapolis, Indiana, 46278, United States
The Vein and Vascular Center at Raleigh Radiology
RECRUITING

Raleigh, North Carolina, 27612, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213-3108, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14623-5863, United States
Velocity Clinical Research, Annapolis
RECRUITING

Annapolis, Maryland, 21401, United States