New shot could replace pills to prevent clots after knee surgery

NCT ID NCT07015905

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests an experimental drug called REGN7508 (cenvacibart) to prevent venous thromboembolism (blood clots) in adults after elective total knee replacement. About 2,000 participants will receive either REGN7508, apixaban, or enoxaparin to compare effectiveness and safety. The goal is to see if REGN7508 works as well or better than standard blood thinners with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: REGN7508 (cenvacibart), a monoclonal antibody that blocks factor XI to prevent blood clots
What this could lead to: If successful, REGN7508 could offer a new option to prevent dangerous blood clots after knee replacement surgery, potentially with fewer bleeding risks than current treatments.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may not prove safer or more effective than existing blood thinners, and there is always a risk of unexpected side effects like bleeding or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

venous thromboembolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENOUS THROMBOEMBOLISM (VTE)

Contacts and locations

Locations

ARENSIA Exploratory Medicine, County Hospital Cluj-Napoca
RECRUITING

Cluj-Napoca, 400006, Romania
Arensia Clinics S.R.L
RECRUITING

Bucharest, 011658, Romania
Bioresearch Partner
RECRUITING

Miami, Florida, 33175, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CARI Clinical Trials
RECRUITING

Riverside, California, 92504, United States
Curalta Clinical Trials
RECRUITING

Westwood, New Jersey, 07675, United States
DRx Clinical Research, LLC
RECRUITING

St. George, Utah, 84770, United States
DRx Clinical Research, LLC; South Texas Bone and Joint Institute
RECRUITING

San Antonio, Texas, 78249, United States
Delray Physician Care Center
RECRUITING

Delray Beach, Florida, 33445, United States
Denver Metro Orthopedics, P.C. Englewood Location
RECRUITING

Englewood, Colorado, 80113, United States
Duke University Health System (Duke Health), Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Flourish Research - San Antonio (Formerly Clinical Trials of Texas)
RECRUITING

San Antonio, Texas, 78229, United States
Futuro Clinical Trials
RECRUITING

McAllen, Texas, 78501, United States
Gulfcoast Research Institute
RECRUITING

Sarasota, Florida, 34232, United States
Gyor-Moson-Sopron Varmegyei Egyetemi Oktato Korhaz
RECRUITING

Győr, Győr-Moson-Sopron, 9024, Hungary
HD Research - First Surgical Hospital
RECRUITING

Bellaire, Texas, 77401, United States
Hospital of Traumatology and Orthopaedics
RECRUITING

Riga, LV-1005, Latvia
Juntendo University Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8431, Japan
Kansai Rosai Hospital
RECRUITING

Amagasaki-shi, Hyōgo, 660-8511, Japan
Keystone Clinical Studies LLC, dba Flourish Research
RECRUITING

Plymouth Meeting, Pennsylvania, 19462, United States
Liepajas regionala slimnica; SIA
RECRUITING

Liepāja, LV-3414, Latvia
Lietuvos sveikatos mokslu universiteto Kauno ligonine
RECRUITING

Kaunas, LT-47144, Lithuania
Lietuvos sveikatos mokslu universiteto ligonine Kauno klinik
RECRUITING

Kaunas, LT-50161, Lithuania
Multi-profile Hospital for Active Treatment Hearth and Brain EAD
RECRUITING

Pleven, 5804, Bulgaria
Multiprofile Hospital for Active Treatment; Sveta Sofia EOOD (MBAL Sveta Sofia),
RECRUITING

Sofia, 1404, Bulgaria
National Hospital Organization Osaka Minami Medical Center
RECRUITING

Kawachi-Nagano, Osaka, 586-8521, Japan
NextStage Clinical Research, All American Orthopedics and Sports Medicine
RECRUITING

Houston, Texas, 77058, United States
ORTO Klinika
RECRUITING

Riga, LV-1005, Latvia
Osaka Saiseikai Nakatsu Hospital
RECRUITING

Kita-Ku, Osaka, 530-0012, Japan
Phoenix Clinical Research
RECRUITING

Tamarac, Florida, 33321, United States
Rigas 2 slimnica, SIA
RECRUITING

Riga, LV-1004, Latvia
Sacred Heart Health System Inc
RECRUITING

Pensacola, Florida, 32504, United States
Saga University Hospital
RECRUITING

Saga, 849-8501, Japan
Samodzieny Publiczny Zaklad Opieki Zdorowotne (SP ZOZ) Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi - Hematology
RECRUITING

Lodz, 92-213, Poland
Semmelweis University
RECRUITING

Budapest, 1082, Hungary
Shoals Medical Trials, Inc.
RECRUITING

Sheffield, Alabama, 35660, United States
Sinai Hospital of Baltimore, Inc.
RECRUITING

Baltimore, Maryland, 21215, United States
Szegedi Tudomanyegyetem; Albert Szent-Gyorgyi Clinical Center
RECRUITING

Szeged, Csongrad-Csanad, 6725, Hungary
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie sp. z o.o.
RECRUITING

Krakow, 31-826, Poland
University Multiprofile Hospital for Active Treatment "Prof. Dr. Stoyan Kirkovich"
RECRUITING

Stara Zagora, 6003, Bulgaria
University of Debrecen
RECRUITING

Debrecen, Hajdú-Bihar, 4031, Hungary
University of Texas (UT); Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Uniwersytecki Szpital Kliniczny nr.2 Uniwersytetu Medycznego w Lodzi
RECRUITING

Lodz, 90-549, Poland
Vidzemes slimnica
RECRUITING

Valmiera, LV-4201, Latvia
Vsi Klaipedos Universitetine Ligonine
RECRUITING

Klaipėda, LT-92288, Lithuania
Yuuai Medical Center
RECRUITING

Tomigusuku, Okinawa, 901-0224, Japan

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