New hope for Platinum-Resistant ovarian cancer: experimental drug ubamatamab enters phase 2 trials

NCT ID NCT06787612

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This phase 2 trial is testing an experimental drug called ubamatamab, alone or combined with other cancer drugs, in 220 people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The study aims to see how safe and effective these combinations are, and how they affect tumor growth and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ubamatamab (a bispecific antibody that targets cancer cells and immune cells)
What this could lead to: If successful, this could provide a new treatment option for people with ovarian cancer that no longer responds to platinum-based chemotherapy.
What could go wrong: This is a phase 2 trial, so it is still early. The drug may not work as hoped, and side effects like cytokine release syndrome are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FALLOPIAN TUBE CANCER OVARIAN CANCER PRIMARY PERITONEAL CANCER

Contacts and locations

Locations

Advent Health Cancer Institute
RECRUITING

Orlando, Florida, 32804, United States
Ankara Bilkent City Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Asan Medical Center, Univ. of Ulsan
RECRUITING

Seoul, 05505, South Korea
Avera Cancer Institute Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Baskent University
RECRUITING

Adana, 01123, Turkey (Türkiye)
CancerCare Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire (CHU) de Quebec - Universite Laval
RECRUITING

Québec, G1J 0J9, Canada
Centre de Santé et de Services Sociaux de la Montérégie-Centre
RECRUITING

Greenfield Park, Quebec, J4V 2H1, Canada
Cerrahpasa Medical Faculty At Istanbul University Cerrahpasa
RECRUITING

Istanbul, 34450, Turkey (Türkiye)
Changhua Christian Hospital
RECRUITING

Changhua, Changhua City, 500, Taiwan
Chi Mei Medical Center
RECRUITING

Tainan, 71004, Taiwan
Gachon University Gil Medical Center
RECRUITING

Incheon, Seoul, 21565, South Korea
Gangnam Severance Hospital
RECRUITING

Seoul, 135-720, South Korea
Gaziantep Medicalpoint Hospital
RECRUITING

Gaziantep, Sehitkamil, 27584, Turkey (Türkiye)
Hacettepe University
RECRUITING

Altındağ, Ankara, 06240, Turkey (Türkiye)
Izmir Ekonomi Universitesi (IEU) Medical Point Izmir Hastanesi (Izmir Economy University Medical Point Izmir Hospital)
RECRUITING

Izmir, 35575, Turkey (Türkiye)
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea
Korea University Guro Hospital
RECRUITING

Seoul, 8308, South Korea
Mackay Memorial Hospital
RECRUITING

Taipei, 10449, Taiwan
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medicalpark Seyhan Hospital
RECRUITING

Seyhan, Adana, 01140, Turkey (Türkiye)
Medipol University Hospital
RECRUITING

Istanbul, Bagcilar, 34284, Turkey (Türkiye)
Memorial Ankara Hospital
RECRUITING

Ankara, 0906520, Turkey (Türkiye)
National Cancer Center
RECRUITING

Gyeonggi-do, Gyeonggi-do, 10408, South Korea
National Taiwan University Hospital
RECRUITING

Taipei, 106, Taiwan
Norton Cancer Institute, St. Matthews Clinic
RECRUITING

Louisville, Kentucky, 40207, United States
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence Cancer Institute
RECRUITING

Portland, Oregon, 97213, United States
Research Institute - McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Sakarya University - Education and Research Hospital
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sbu Doctor Abdurrahman Yurtaslan Ankara Onkoloji Suam
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 3080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
Taipei Municipal Wan Fang Hospital
RECRUITING

Taipei, 116, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11211, Taiwan
Tampa General Hospital Cancer Institute
RECRUITING

Tampa, Florida, 33606, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Hilliard, Ohio, 43026, United States
The University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
The University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
Tri-Service General Hospital
RECRUITING

Taipei, 114202, Taiwan
UC San Diego Health
RECRUITING

La Jolla, California, 92037, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Miami Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Pittsburgh Medical Center, Magee-Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
West Penn Hospital of Allegheny Health Network
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

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