HEALTHY VOLUNTEERS

This study tested an experimental RSV vaccine in about 4500 adults aged 60 and older. Half received the vaccine and half received a placebo. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be dangerous for ol…

This early-stage study tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. Researchers gave different doses to see if it was safe and how well it triggered an immune response. The goal is to develop a more effective flu vaccine using mRNA technology.

This study tested Takeda's dengue vaccine in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo three months apart. The main goals were to check for side effects and measure the body's immune response against all four type…

This study tested a new dengue vaccine (TDV) in over 20,000 healthy children aged 4 to 16. The goal was to see if two doses could prevent dengue fever caused by any of the four dengue virus types. Results help determine how well the vaccine works and its safety.

This study tested a single-shot vaccine designed to protect against two respiratory viruses—RSV and hMPV—in adults aged 60 and older. Researchers gave different doses to 646 volunteers and checked for side effects and immune responses. A booster shot was also tested 12 months lat…

This early-stage study tested whether a new vaccine called HSV529 is safe for people. It included 69 healthy adults aged 18 to 40, some with and some without herpes infection. Participants received three shots of the vaccine or a placebo and were monitored for side effects over a…

This early-stage study tested a new flu vaccine that includes an extra H3 virus strain to see if it is safe and boosts the immune system better than standard flu vaccines. About 400 healthy adults aged 18-49 and 60+ took part. The goal is to improve protection against influenza, …

This study tested a new meningitis vaccine (MenACYW) in 463 healthy adolescents aged 10-17. It compared the new vaccine to an existing one (Nimenrix®) and also checked safety when given alongside HPV and Tdap-IPV vaccines. The goal was to see if the new vaccine provides similar p…

This study tested a single dose of an investigational meningitis vaccine (MenACYW) in 447 healthy people aged 12 months and older in Vietnam. The vaccine aims to protect against four types of meningococcal bacteria (A, C, W, Y) that can cause serious infections. Researchers measu…

This study looked at whether adults aged 65 and older can safely get a high-dose flu vaccine and a Moderna COVID-19 booster at the same time. About 306 volunteers who had already received two doses of the Moderna COVID-19 vaccine took part. Researchers measured side effects and i…

This early-stage study tested an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV. Healthy adults aged 18-49 and 60+ received a single shot at different doses. Researchers monitored safety and immune responses for about 6 months.

This study tested a new vaccine called ShigETEC in 196 healthy Bangladeshi adults and children. The vaccine aims to protect against two bacteria that cause severe diarrhea. Researchers checked if the vaccine is safe and if it triggers an immune response. This is an early-phase tr…

This study tested two different doses of an experimental H7 bird flu vaccine, each combined with an immune booster (MF59), against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune res…

This study looked at whether a booster shot of the MenQuadfi vaccine is safe and effective for toddlers aged 12 to 23 months who had already received a meningococcal vaccine as babies. The goal was to see if the booster could strengthen their protection against a serious bacteria…

This study tested a new vaccine to protect infants and toddlers against four types of meningococcal bacteria that can cause meningitis. Over 1,500 healthy children in India and South Africa received the vaccine alongside their routine shots. Researchers checked if the vaccine tri…

This study tested several versions of a flu vaccine to see if they are safe and how well they boost the immune system. 210 healthy adults (ages 18-30 and 50+) received different vaccine recipes, some with an added ingredient to strengthen the immune response. The goal was to find…

This study tested a new meningitis vaccine (MenACYW) in 840 healthy infants and toddlers. Participants received two doses at 6 and 12 months old. The goal was to see if the new vaccine works as well as an existing vaccine (Nimenrix) and is safe. The study is complete and aims to …

This early-stage study tested the safety and immune response of new vaccines that combine protection against influenza, RSV, hMPV, and parainfluenza virus type 3. A total of 270 healthy adults aged 18 to 49 received a single shot of one of the vaccine formulations. Researchers mo…

This study tested an experimental vaccine designed to protect against five strains of meningococcal bacteria (A, B, C, W, Y), which can cause serious infections like meningitis. About 1,200 healthy adolescents and young adults received the vaccine to check its safety and how well…

This study tested a new medicine called Mim8 for people with hemophilia A, a condition where blood doesn't clot properly. Mim8 is a shot given under the skin that helps replace the missing clotting factor. The trial included 275 people, some healthy and some with hemophilia, to s…

This study tested whether a natural supplement called Immulina can help the body's immune system fight off upper respiratory viruses like the flu. Researchers gave the supplement or a placebo to 492 healthy adults aged 18-59 and 65+ for 20 weeks. They measured changes in natural …

This early-phase trial tested a new radioactive tracer called 18F-LNC1007 in 8 people—healthy volunteers and cancer patients with few small tumors. The goal was to see how the tracer moves through the body, how much radiation it gives, and if it is safe. Participants had PET/CT s…

This study tested a new imaging agent called [18F]APN-1607 to see if it can help diagnose Alzheimer's disease using PET scans. Researchers compared brain scan patterns in 230 people with Alzheimer's, mild cognitive impairment, and healthy volunteers. The goal was to improve early…

This early-phase trial tested a new imaging agent called 68Ga-LNC1007 in 8 adults—some healthy and some with solid tumors. The goal was to check its safety and how it moves through the body after a single injection. Participants were monitored for about 3 weeks, including scans a…

This study tested two new tools to make tuberculosis (TB) skin tests better. Researchers compared a new, easy-to-use needle against the standard method and tried a non-invasive scanner to read the results. The goal was to see if these tools could make TB testing simpler and more …

This study tested whether a cookie made with quinoa could help healthy adults maintain normal blood fat and sugar levels, potentially lowering the risk of obesity and metabolic syndrome. Sixty healthy volunteers ate either a regular cookie or a quinoa-based cookie for 12 days, wi…

This study tested whether a high-dose flu vaccine works better than the standard dose for adults aged 60 and older. About 1,500 healthy volunteers received either the high-dose or standard-dose shot. Researchers measured immune responses 28 days later and tracked safety. The goal…

This study tested a high-dose flu vaccine against a standard-dose one in 2,100 adults aged 60 and older in Japan. The goal was to see if the high-dose shot triggers a stronger immune response. Results showed the high-dose vaccine produced higher antibody levels, which may offer b…

This study tested seven cosmetic products to see if they could prevent skin darkening caused by high-energy visible light (blue-violet light) in 33 healthy adults. Participants had products applied to their back and were exposed to a specific type of light over four days. Researc…

This study tested a new rabies vaccine (VRVg-2) in over 1,700 healthy children and adults in Thailand. The goal was to see if it works as well as current rabies vaccines when given before exposure to the virus. Participants received three doses, and some got a booster shot later …

This study looked at whether taking Rhodiola rosea (golden root) for a week can help resistance-trained adults lift more and think sharper. Twenty-seven healthy men and women tried low and high doses, a placebo, and a no-pill control. They did strength tests, a cycling sprint, an…

This study tested whether combining a low dose of methylphenidate (a drug used for ADHD) with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in a 6-week program. The goal was to see …

This study tested whether a supplement called TRPTI (oleoylethanolamide) can improve how the body processes sugar in healthy adults. Nineteen participants took either 150 mg, 300 mg, or a placebo in random order. Researchers measured blood sugar and insulin levels after a sugary …

This study looked at whether three different food supplements could improve skin firmness, elasticity, and radiance in healthy women aged 40 to 60. Over 130 women took the supplements or a placebo daily for three months. Researchers measured skin properties like firmness and cell…

This study tested whether a short session of static neck stretching can lower blood pressure in healthy adults. 25 volunteers participated, and researchers measured blood pressure, tissue stiffness, and heart rate before and after stretching. The goal was to see if stretching rel…

This study looked at 342 healthy volunteers to find the best time to give a combination of two sedative drugs (remimazolam and remifentanil) during a painless gastroscopy. The goal was to reduce side effects like coughing, body movement, and drops in blood pressure or oxygen leve…

This pilot study looked at whether the Feldenkrais Method, a gentle movement and awareness practice, could help reduce stress and improve well-being in 24 healthy but sedentary women aged 26-59. Participants either took eight daily 90-minute Feldenkrais sessions or were in a cont…

This study looked at how the amount of water you drink affects vitamin C levels in your blood. Healthy adults aged 18-35 followed a low-vitamin C diet and then took vitamin C pills and injections. Researchers measured their blood and urine to understand how the body processes vit…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults 65 and older who received the 2020-2021 flu vaccine. The samples were taken before and after vaccination and sent to experts at the WHO, CDC, and FDA to help decide which flu strain…

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body absorbs and processes each version and to check for any side effects. Participants received a single injection and were monitored…

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women, some with placental complications like pre-eclampsia and some without. The goal was to see if these proteins could serve as early markers for such complications. No treatment was given; …

This study looked at how different types of feedback (like social or monetary) affect decision-making in 76 healthy adults. Researchers used brain scans and a mild stimulation technique to understand which brain areas are involved. The goal is to apply this knowledge to help peop…

This study looked at how two different versions of an experimental drug, PF-07976016, are absorbed into the blood after a single dose. It involved 12 healthy adults and was completed by Pfizer. The goal was to compare the drug levels, not to treat any disease.

This study looked at how vitamin E is absorbed and used by the body in normal-weight, overweight, and obese women, including those with type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after different meals and vitamin C doses. The goal was to better un…

This early-stage study tested the safety of a new drug called SEP-631 in 120 healthy adults aged 18 to 60. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. The goal was to gather safety information, not to treat…

This early-phase study tested the safety and how the body absorbs a new drug called VRG50635. It involved 22 healthy adults aged 19 to 55. The goal was to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looked at how the painkiller oxycodone behaves in the body when given as a nasal spray or an oral solution. Eight healthy adults took a single dose of each form on separate days. Researchers measured drug levels in the blood to understand absorption and side effects. T…

This study is for research only and does not treat any disease. It looks at how safe a single dose of the drug cenerimod is and how the body absorbs and breaks it down. Twenty healthy volunteers (10 Japanese and 10 Caucasian) take part. The goal is to see if the drug acts differe…

This study tested a new way to measure how hard someone is breathing while using a non-invasive ventilator (a mask that helps with breathing). Researchers studied 12 healthy adults to see if a quick airway occlusion (briefly blocking the airflow) could accurately estimate breathi…

This early-stage study tested the safety and how the body processes a new drug called ALN-AGT01 RVR. It involved 42 healthy adults who received either a single dose of the drug or a placebo. The main goal was to check for side effects and measure drug levels in the blood and urin…

This study looked at how nicotine enters the body from different oral nicotine pouches. Twenty-seven healthy adults who regularly use snus or nicotine pouches took part. They used four different products, and researchers measured nicotine levels in their blood and how much nicoti…

This study looked at how aging skin cells (senescent cells) appear around small wounds in healthy adults. Researchers compared younger people (ages 20-39) with older adults (70+) to see if there are differences in wound healing. The goal is to better understand aging and age-rela…

This study looked at 12 people with chronic bilateral vestibular hypofunction (a balance disorder causing blurry vision during head movement) and 12 healthy volunteers. Researchers measured how quickly and often the eyes make tiny, automatic saccades during head turns to see if t…

This study looked at whether a new drug called EB-1020 has the potential to be abused, like other stimulants. Healthy adults who use stimulants recreationally were given single doses of EB-1020, a placebo (sugar pill), or d-amphetamine (a known stimulant) to compare their effects…

This early-stage study tested the safety of a new drug, NAV-240, in 24 healthy adults. Participants received multiple doses of either the drug or a placebo. The main goal was to see what side effects occurred and how the drug moved through the body. This study did not aim to trea…

This study tested a single injection of a new medicine (NNC0194-0499) for fatty liver disease in 33 adults with various levels of liver function, including healthy volunteers. Researchers measured how the drug moves through the body and checked safety. The goal was to understand …

This study looked at how collagen from drinks gets into the blood. 25 healthy men drank different collagen products, and their blood was tested over 4 hours. The goal was to see which amino acids and small protein pieces appear after drinking collagen, compared to a placebo.

This early-phase study tested a single dose of the experimental drug NRS 033 in 24 healthy adults aged 18 to 55. The main goal was to check for side effects and measure how the drug moves through the body. No treatment was given for any disease, so this study helps lay the ground…

This study looked at how taking a drug called rilzabrutinib with or without food, and in different pill forms, changes its levels in the blood. 24 healthy adults each took a single dose under different conditions. The goal was to gather information for future dosing, not to treat…

This study tested a new ultrasound technique to measure blood flow inside the shin bone of 30 healthy men. The goal was to see if the method could detect normal changes in bone blood flow during simple activities like squeezing a handgrip or having a blood pressure cuff inflated.…

This early-stage study tested a single dose of AJ302-IM in 57 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection. The goal was to check for side effects and measure drug levels in the blood, not to tr…

This study tested how well two different tablet forms of the drug rilzabrutinib are absorbed by the body, and whether food changes that absorption. 28 healthy adults aged 18-55 took single doses of each tablet form in random order. The goal was to gather information, not to treat…

This study looked at how genetic differences affect the way the body activates a common blood pressure medication called enalapril. Researchers gave the drug to 21 healthy volunteers and measured how well their bodies converted it into its active form. The goal was to understand …

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body processes it. The medicine aims to reduce chronic inflammation, which can lead to heart and kidney problems. Participants received either the medicine or a…

This early-stage study tested the safety of a new drug called BB-025 in 72 healthy adults. Some participants received BB-025 alone, while others got it after another drug, BB-031. The goal was to see if BB-025 is safe and how the body processes it, not to treat any disease.

This study looked at how overeating at different times of day affects inflammation and metabolism in 16 healthy adults. Researchers measured hundreds of markers in the blood to see if eating more calories in the evening is worse for the body than eating them earlier. The goal is …

This completed study looked at whether tiny samples of nasal fluid can help doctors objectively measure how severe respiratory conditions like COPD, asthma, hayfever, and sinusitis are. Researchers compared 111 adults—some healthy and some with these conditions—using a special de…

This study tested a new tablet form of Magne-B6 (magnesium and vitamin B6) against the current liquid version in 24 healthy adults. The goal was to see how well the body absorbs each form when taken on an empty stomach. Results will help determine if the new tablet works as well …

This study tested a single dose of the drug teprotumumab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and if it is safe. Participants were closely monitored for side effects and drug levels in the blood.

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers a…

This study used special 3D cameras to take pictures of people's torsos without any radiation. Researchers wanted to learn more about body shapes in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. About 199 participants aged 2 and older had their to…

This early-stage study tested the safety of a new drug called ARGX-213 in 88 healthy adults. Researchers also measured how the drug moves through the body and affects immune markers. The study is complete and helps lay the groundwork for future research, but offers no direct trea…

This study looked at 50 healthy adults to see if changing arm position makes veins in the armpit and collarbone area show up larger on ultrasound. Participants had their veins measured with their arm by their side and with their arm raised and rotated. The goal is to help doctors…

This study tested how well vitamin A added to bouillon (broth) is absorbed by the body, compared to an oil-based supplement. Fifty-eight healthy women ate a breakfast containing one of three vitamin A formulations in bouillon, and had their blood tested afterward. The goal was to…

This study looks at why some medications, like the antifungal drug voriconazole, can make skin extremely sensitive to light, causing a reaction similar to a bad sunburn. Researchers will measure gene activity in skin samples and test how ultraviolet light affects the skin of peop…

This study looked at whether a COVID-19 mRNA vaccine (mRNA-1273.712) affects heart muscle cells in healthy people aged 12 to 30. About 1000 participants received either the vaccine or a placebo, and researchers measured a heart enzyme called troponin at several time points. The g…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. 66 healthy adults and people with depression took either the drug or a placebo for 3 days. Researchers used memory tests and high-resolution MRI scans …

This early-stage study tested the safety of a new drug called KINE-101 in 24 healthy adults. Participants received daily infusions of the drug or a placebo for 7 days. The goal was to see if the drug is safe and how the body processes it. No treatment benefit was expected since a…

This study looked at whether a dietary supplement made from silver fir branches, called Belinal®, is safe for the liver and kidneys. Fifteen healthy adults took the supplement daily for 14 days. Researchers measured blood markers of liver and kidney function at several time point…

This early-stage study tested a new oral drug called AN2-502998 in 72 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects and measured drug levels in the blood. The goal …

This early-phase study tested a new drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers to see if it is safe and how the body processes it. Researchers are exploring B-OT as a potential treatment for infectious diseases and cancer. Participants took the drug as cap…

This study looked at how two drugs, epaminurad and C2406, affect each other in the body and whether they are safe together. It involved 18 healthy adults aged 19 to 50. The goal was to measure drug levels and check for side effects, not to treat any disease.

This study looked at whether adding motivation to mental imagery or action observation could increase lower back strength in healthy adults. Forty participants were split into four groups: some did mental imagery or action observation alone, and others did the same but with added…

This study tested a new tablet that combines two cancer drugs (zanubrutinib and sonrotoclax) into one pill. Twenty-four healthy adults took the combo tablet and the separate pills at different times to compare how the body absorbs them. The study also checked if taking the tablet…

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database of normal gait patterns. Researchers measured muscle activity in the legs using sticky electrodes while children walked back and forth. The goal is to help doctors better under…

This early-stage study tested a new drug called AZD1163 in 108 healthy volunteers to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or IV. The goal was to check for side effects and measure drug levels in the blood…

This early-stage study tested the safety and how the body processes a new drug called atumelnant in 21 healthy adults (both Japanese and Caucasian). Participants received either the drug or a placebo. The goal was to measure drug levels and check for side effects, not to treat an…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This early-stage study tested a single dose of the experimental drug ORKA-001 in 24 healthy volunteers aged 18 to 65. The main goal was to check for side effects and how the drug moves through the body. No treatment for any disease was given; the study simply gathered safety info…

This study used a special brain scan (PET imaging) to measure a chemical messenger called glutamate in 27 men with autism, Fragile-X syndrome, or no condition. The goal was to see how brain signaling differs between these groups. No treatment was given; it was purely an observati…

This early-stage study tested the safety and side effects of a new drug called BMS-986278 in 42 healthy adults. Researchers also checked if the drug affects the heart's electrical activity. The goal was to gather safety information, not to treat any disease.

This study tested whether a new version of the drug dupilumab works the same in the body as the current version. It involved 182 healthy adults aged 18 to 65 who received a single injection of either the new or current drug. The goal was to compare drug levels and safety, not to …

This study looked at whether taking creatine and L-arginine together, just once, can improve short bursts of exercise and mental reaction time in healthy, active men. Eighteen men tried each supplement alone, together, or a placebo, then did sprint, jump, and brain tests. The goa…

This study looked at the long-term safety of a malaria drug called tafenoquine. Six hundred healthy volunteers took either the drug or a placebo for one year. The main goal was to check for any serious eye problems. The study is complete and helps understand the drug's safety ove…

This study looked at how two different versions of the drug centanafadine are absorbed by the body. 62 healthy adults took either a sustained-release tablet or an extended-release capsule. The goal was to compare the two forms, not to treat any disease.

This study looked at how the drug maribavir is absorbed and processed in healthy adults of Japanese descent compared to non-Hispanic Caucasian adults. Twenty-four volunteers received a single oral dose of maribavir, and researchers measured drug levels in the blood to check for d…

This early-stage study tested the safety and tolerability of Ginkgolide B injection in 36 healthy adults aged 18 to 45. Participants received single and multiple doses to see how the drug moves through the body. The goal was to check for side effects and measure drug levels, not …

This study looked for better ways to measure what people eat by checking for natural markers in blood and hair. Fifty-nine healthy men ate carefully controlled diets for 12 weeks while researchers tracked changes in these markers. The goal was to see if these markers could reliab…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity while participants viewed these images. The goal was to better understand the link between drinking a…

This study tested whether gentle electrical stimulation during naps can increase certain brain waves linked to emotional well-being and stress resilience. 72 healthy adults who nap regularly took part in up to three visits, wearing a special cap to measure brain activity. The goa…

This study looked at how the injection site (upper arm, thigh, or abdomen) affects the absorption of a drug called KAI-9531 in healthy volunteers with different body weights. 51 participants each received a single injection in different spots to compare drug levels in the blood. …

This study tested how well risankizumab enters the body when given by a prefilled pen compared to a standard syringe. Fifty-nine healthy adults received the drug one way or the other, and researchers measured drug levels in the blood and watched for side effects. The goal was to …

This study looked at whether giving the drug zilucoplan by a prefilled syringe or an auto-injector leads to similar levels in the blood. It involved 14 healthy adults and was already completed. The goal was to check safety and how the body processes the drug, not to treat any dis…

This study looked at how a new drug called ENX-104 is processed by the body in 12 healthy volunteers. Researchers compared taking the drug as a liquid versus a tablet, and whether a high-fat meal changes absorption. The goal was to gather safety and dosing information, not to tre…

This early-stage study tested a single dose of ENX-104 in 10 healthy volunteers to see how safe it is, how much of the drug reaches the brain, and how long it stays in the body. Researchers used PET scans to measure the drug's effect on brain receptors. The study is complete and …

This study looked at how the drug golcadomide is handled by the body in people with moderate or severe liver damage compared to healthy volunteers. 29 adults received a single dose to measure drug levels and check for side effects. The goal was to understand dosing needs for pati…

This early-stage study tested a new tablet called HD-P023 in 40 healthy adults to see how it compares to taking two separate diabetes drugs (teneligliptin and empagliflozin) together. The goal was to measure how the drugs are processed by the body and check for safety. No treatme…

This study looked at how two drugs that affect the body's endocannabinoid system (similar to marijuana) influence insulin production and action. 45 healthy men aged 21-55 received different combinations of these drugs or a placebo over four visits. The goal was to understand how …

This study looked at how the body absorbs BGB-43395 when taken as two different tablet types and with or without food. Fifty-one healthy adults took a single dose of the drug. The goal was to gather information on drug levels and safety, not to treat any disease.

This study looked at how doing isometric (static) exercises for the thigh muscles at different knee angles affects balance, joint awareness, and physical performance in healthy adults aged 20-30. Thirty participants did an eight-week training program three times a week. The goal …

This study looked at how a single dose of the drug BMS-986278 behaves in people with severe kidney problems or those on dialysis, compared to healthy volunteers. 27 adults took part to help researchers understand safety and drug levels. The goal was to gather information, not to …

This study gave a single dose of a radioactive-labeled drug (OPC-167832) to 8 healthy men to measure how much leaves the body in urine and stool. The goal was purely to understand the drug's journey, not to treat any disease. Participants stayed in a research unit for the entire …

This study looked at how a single 16 mg dose of selatogrel is absorbed, broken down, and tolerated in 32 healthy adults (16 Japanese, 16 Caucasian). It was not meant to treat any disease. Participants stayed in a clinic for 3-4 days and had follow-up checks. The goal was to gathe…

This study tested a new experimental drug, NNC0113-6856, in healthy men for the first time. The goal was to check safety and how the drug moves through the body, not to treat any disease. 70 healthy male volunteers received either a single oral dose or an injection into the vein.

This study tested a non-invasive device that gently stimulates a nerve in the ear to see how it affects brain activity and the body's stress response. 44 healthy adults received either real or fake stimulation during a single session. The goal was to understand the basic science,…

This study looked at how brain scans (fMRI and MEG) relate to electrical signals recorded directly from the brain (intracranial EEG) in people with epilepsy and healthy volunteers. The goal was to better identify the area causing seizures and map healthy brain networks to avoid d…

This study looked at how 10 healthy volunteers processed 10 different drugs and their breakdown products. The goal was to describe each person's unique metabolic profile by measuring drug levels in the blood. No treatment or cure was tested—just observation to learn more about ho…

This study looked at how two common drugs—phenytoin and itraconazole—change the way the body processes BGB-16673. It involved 37 healthy adults aged 18 to 65. The goal was to measure drug levels in the blood, not to treat any disease.

This study looked at how healthy adults perform simple tapping tasks to understand the complexity of their movement control. Researchers used special math tools (fractal analysis) to measure patterns in performance. The goal was to explore whether these measurements could be usef…

This study looked at how the body processes cagrilintide, a drug being developed for weight management, in people with different levels of liver function. It involved 32 adults, including those with liver impairment and healthy volunteers. The goal was to measure drug levels in t…

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults participated, and researchers measured drug levels and checked for side effects. The goal was to unders…

This study looked at how the body absorbs different versions of the drug povetacicept in 136 healthy adults. The goal was to compare the drug's formulations and check for safety. No treatment was given—just careful measurement of drug levels in the blood.

This study looked at how carbamazepine, a drug used for seizures, changes the amount of mirdametinib in the blood. Thirty-six healthy adults took both drugs by mouth, and researchers measured drug levels over time. The goal was to understand if carbamazepine speeds up the breakdo…

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults aged 18-45. Researchers used PET brain scans to see how much of the drug attached to a specific brain receptor (5-HT2A) and checked safety and drug levels in the blood. The goal was …

This study looked at how much of the drug deucravacitinib passes into breast milk and blood after a single dose in 8 healthy women who were breastfeeding. The goal was to understand potential infant exposure. Results help guide safe use during breastfeeding.

This early-stage study tested the safety of a new drug called LAD191 in 69 adults—some healthy and some with an autoimmune disease. Researchers gave single or multiple doses to see how the body handles the drug and whether it causes side effects. The goal was not to treat the dis…

This study looked at whether giving growth hormone to healthy men aged 25 to 50 could improve their immune system function. Researchers used an infusion pump to deliver either growth hormone or a placebo over several weeks. The goal was to understand how growth hormone affects th…

This study tested a new biosimilar drug called MB04 against the approved drug Enbrel in 141 healthy men. The goal was to see if the body processes MB04 the same way as Enbrel, and to check for side effects. Participants received a single dose of each drug in a random order, and r…

This early-stage study tested a new oral drug, MT-501, in 72 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo. The main goal was to check for side effects and any changes in lab results, heart activity, or vital…

This study looked at how the brain keeps our eye movements accurate, even as we grow or change. Thirty-six healthy adults had their brains scanned with MRI while performing special eye-tracking tasks. The goal was to identify which brain areas are involved in adjusting eye moveme…

This study looked at how a drug called quinidine changes the way the body processes a new schizophrenia medicine, SEP-380135. It involved 12 healthy adults who took a single dose of SEP-380135 with and without quinidine. The goal was to understand potential drug interactions, not…

This study tested whether online nutrition workshops could help hospital employees eat a more plant-based, environmentally friendly diet. Sixty-four healthy adults working at a hospital took part in a 13-week program with either intensive or light digital support. Researchers mea…

This study looked at how two drugs, Roflumilast (used for COPD) and Sitagliptin (used for diabetes), affect blood sugar and gut hormones in 29 healthy adults aged 21-55. Participants took the drugs or placebos and had their blood tested after a meal. The goal was to understand ho…

This early-stage study tested the safety and tolerability of a new drug, SAR441344, in 56 healthy adults. Participants received either the drug or a placebo through an IV or injection. The main goal was to see if the drug caused any side effects, not to treat any disease.

This early-stage study tested a single injection of an experimental drug called NNC0582-0001 in 56 healthy adults. The main goal was to check safety and how the drug moves through the body, not to treat any disease. Participants were followed for about a year after the injection.

This early-stage study tested a new drug, SIM0278, in 60 healthy Chinese adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single shot or multiple shots. The main goal was to check for side effects, not to treat any…

This early-phase study tested the safety and how the body processes TAK-123 in 10 healthy Japanese men aged 20 to 45. Participants received a single intravenous dose, and researchers measured drug levels and side effects. The study was completed and provides basic safety data, bu…

This study checked if a wearable motion sensor (BTS G-sensor) can accurately measure how high people jump. 29 healthy women aged 18-35 did countermovement jumps while wearing the sensor and also being measured by a validated smartphone app. The goal was to see if the sensor's mea…

This study looked at whether L-lysine, a common amino acid, can change levels of the hormones aldosterone and cortisol in healthy men. Twenty volunteers took L-lysine or a placebo for 13 days, then switched. The goal was to learn how the body controls these hormones, not to treat…

This study looked at two new dissolvable forms of vonoprazan (a stomach acid reducer) to see how well the body absorbs them compared to the regular tablet. Twenty-five healthy adults took single doses of each form, some without water and some mixed with water given by syringe. Th…

This study looked at whether taking a nap in different places—including a special sleep module—helps healthy adults stay alert and drive better. Forty good sleepers aged 20 to 50 completed driving simulations and alertness tests after napping or resting. The goal was to see which…

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. Researchers split 80 healthy young adults into two groups: one walked outdoors in nature, the other walked on a …

This study tested a new medicine called etavopivat, being developed for sickle cell disease, to see if it changes the heart's electrical activity. Thirty-three healthy adults received different doses of the drug, a placebo, or an approved heart medicine. The goal was to check for…

This early-stage study tested a new medicine called NNC0581-0001 in 48 adults to see if it is safe and how the body handles it. Some participants were healthy, and others had fatty liver (hepatic steatosis). Participants received either the drug or a placebo by injection under th…

This study looked at how a small difference in a gene called CETP affects the way 'good' cholesterol (HDL) works in the body. Researchers compared two groups of healthy men—those with one version of the gene versus another—to see how well their HDL could remove cholesterol from c…

This study looked at how different types of light affect tiredness and thinking skills in healthy adults after they stayed awake all night. 18 volunteers aged 18 to 40 were tested. The goal was to learn more about sleep loss, not to provide a treatment.

This study looked at tissue samples from tonsils, lymph nodes, intestines, and lungs of people with HIV and healthy volunteers. The goal was to measure virus levels and immune cells to better understand how HIV behaves in the body during treatment. About 386 adults took part, and…

This study tested a new on-body injector for risankizumab, a drug used for conditions like psoriasis and arthritis. 260 healthy adults received the drug either through the new injector or a standard syringe. Researchers measured how much drug got into the blood and how the body p…

This study tested how well healthy adults tolerate a new medicine called TAK-881, given as an injection under the skin. 64 healthy volunteers aged 18-50 received one or more doses to check for side effects and how the body processes the drug. The goal was to see if the injection …

This early-stage study tested a single dose of EA5 in 28 healthy adults to see if it is safe and how the body processes it. Participants received either EA5 or a placebo, and researchers monitored side effects and drug levels in the blood. This trial does not aim to treat any dis…

This study looked at how two different versions of an inhaled drug (called TPIP) are absorbed by the body. 42 healthy adults took single doses of each version. The goal was to see which version delivers the drug more consistently, which helps design better treatments for the futu…

This early-stage study tested the safety and how the body handles two experimental antibodies (AZD5396 and AZD8076) in 61 healthy adults aged 18-60. The antibodies were given as injections followed by a mild electrical pulse to help them enter cells. The goal was to check for sid…

This study looked at whether being in labour slows down how fast the stomach empties a light meal. Researchers used ultrasound to measure stomach size in 43 women: those in labour with or without epidural, pregnant women not in labour, and non-pregnant women. The goal is to help …

This study looked at how a new drug called linaprazan glurate interacts with clarithromycin, amoxicillin, and bismuth potassium citrate. It involved 56 adults, some healthy and some with H. pylori infection. The goal was to measure drug levels in the blood, not to treat any disea…

This early-stage study tested a single dose of the drug selonabant in 40 healthy adults aged 18 to 30. The main goal was to check for side effects and see how the body processes the drug. Participants received either the drug or a placebo, and researchers monitored their health c…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, travel through the blood and lungs in 34 healthy adults aged 18 to 55. Participants took the drugs by mouth and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels in th…

This study looked at how a new drug called KarXT interacts with three common mood stabilizers (lithium, valproic acid, and lamotrigine) in 133 healthy volunteers. Researchers measured drug levels in the blood to see if combining them changes how each drug works. The goal is to en…

This early-stage study tested several new versions of insulin lispro in 54 healthy volunteers to see how quickly the body absorbs and clears them, and whether they cause any side effects. The goal was to gather safety and drug-level information, not to treat diabetes. Participant…

This study looked at how the drug belumosudil affects certain proteins in the liver and gut that process other medications. Fifty-two healthy men took belumosudil along with other drugs to measure changes in how those drugs are absorbed and cleared. The goal was to understand pot…

This study tested the safety and how the body handles two experimental imaging agents (GEH200521 and GEH200520) in 22 healthy volunteers. The goal was to see if they are safe and how they travel through the body, not to treat any disease. This is an early-stage (Phase 1) study, s…

This study looked at how cooling the scalp and timing brain stimulation with brain waves can change brain activity. Healthy adults wore a cooling cap or received magnetic pulses while their brain waves and muscle responses were measured. The goal was to better understand how the …

This study looked at how healthy people remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI to understand which parts of the brain are involved in recalling memories. The goal was to learn more about memory and attention, n…

This study looked at how repotrectinib changes the way the body processes other drugs. Thirty healthy adults took a mix of common medications with and without repotrectinib to see if levels of those drugs went up or down. The results will help doctors adjust doses when repotrecti…

This early-stage study tested a single dose of an experimental drug called BNC in 75 healthy volunteers aged 55 and older. The goal was to see if the drug is safe and how the body processes it, as a first step toward possibly treating Alzheimer's disease. Participants took either…

This study involved 14 healthy volunteers to measure oxygen and carbon dioxide levels in the throat (hypopharynx) during high-flow oxygen therapy through a nasal cannula or face mask, and standard oxygen therapy through a non-rebreather mask. The goal was to understand how differ…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults (65 and older) after they received their seasonal flu vaccine. The samples were sent to experts to help decide which flu strains to include in future vaccines. The study did not tes…

This study tested two different versions (a tablet and a capsule) of an experimental medicine called NDec in 44 healthy adults. The medicine is being developed for sickle cell disease, but this study only measured how the body absorbs each form. Participants received both version…

This study looked at how much nicotine gets into the blood and how strong the urge to smoke is when using blu disposable e-cigarettes compared to a regular cigarette. Twenty adult smokers who smoke at least 10 cigarettes a day took part. Researchers measured nicotine levels and s…

This early-stage study tested the safety of a new drug called ITI-333 in 32 healthy adults aged 18 to 45. Participants received either the drug or a placebo once daily for 14 days. The goal was to see how the body processes the drug and check for any side effects. This research h…

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used brain scans, EEG, and eye tracking to understand how babies develop skills like moving, socializing, and thinking. The goal was to learn more about normal…

This study looked at how a 12-week strength and power training program affects movement patterns, leg strength, and dance performance in 30 healthy college sports dancers. Participants were split into two groups: one did strength training three times a week, and the other did not…

This study tested a new device called E-celsius, which is a small pill you swallow that measures your body temperature as it travels through your digestive tract. The goal was to see if this pill gives accurate temperature readings compared to standard methods like probes in the …

This early-phase study tested a new antibody called AK1967 (Procizumab) in 24 healthy men to see if it is safe and how the body processes it. The antibody targets a protein that may worsen heart shock. This is a first step before testing it in patients with heart problems.

This study tested two different tablet versions of a drug called UCB0022 in 14 healthy adults aged 18 to 55. The goal was to see how much of the drug gets into the blood and if one tablet works better than the other. Researchers also checked for any side effects. This is an early…

This study tested whether two different injection devices deliver the same amount of amlitelimab into the body. 212 healthy adults received a single dose of the drug through one of the devices. Researchers measured drug levels in the blood and checked for side effects to see if t…

This study tested a new drug called TAK-004 in 121 healthy adults to see if it is safe and how the body handles it. Participants received either TAK-004 or a placebo as an injection under the skin, and some got one dose while others got multiple doses. The goal was to learn about…

This study looked at whether a special MRI scan (T1rho) can reliably measure hip cartilage in 31 healthy adults. The goal is to find normal values and see if the measurements are consistent. This could help doctors detect early signs of hip osteoarthritis before symptoms start.

This early-stage study tested the safety and tolerability of a new drug called LAD603 in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to see how the body processes it and whether it causes side effects. The goal was not to treat any disease,…

This study looked at how brief periods of weightlessness during parabolic flights affect spatial memory, brain structure (especially the hippocampus), and stress-related chemicals in the blood. Twenty-four healthy adults completed computer-based memory tests and had brain scans b…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination over two months. The goal was to learn more about the body's defens…

This early-stage study tested the safety and tolerability of a new drug called AG-181 in 88 healthy adults. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug was processed in the body. The study also looked at whether food…

This study tested whether a non-invasive camera can capture images of tiny blood vessels (microcirculation) during brief periods of weightlessness on a special airplane. Sixteen healthy volunteers flew on parabolic flights, experiencing about 21 seconds of zero gravity at a time.…

This study tested a new microneedle patch to collect fluid from the skin of 20 healthy volunteers and people with eczema (atopic dermatitis). The goal was to see how much fluid could be collected and how well it was tolerated. This early-stage research aims to improve how we samp…

This study aimed to understand how meditation and hypnosis affect our brain's sense of self. Researchers used brain scans (fMRI) on 100 healthy volunteers while they practiced mindfulness and hypnosis techniques. The goal was to identify which brain areas become active during the…

This study looked at how a breast cancer drug called SAR439859 is absorbed, broken down, and removed from the body. Six healthy postmenopausal women took a single dose of the drug with a tiny radioactive marker. Researchers measured the drug in blood, urine, and stool to understa…

This early-stage study tested a new drug called KINE-101 in 40 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single dose through an IV or injection. The study is complete and provides important safety in…

This early-stage study tested the safety of a new drug called VNRX-7145 in 83 healthy adults aged 18 to 45. Participants received either a single dose or multiple doses over 10 days to see how the drug moves through the body and if it causes side effects. The goal was not to trea…

This study tested a new version of the allergy medicine fexofenadine to see how well it enters the bloodstream when taken with or without water, compared to the current coated tablet taken with water. Twenty-five healthy adults participated under fasting conditions. The goal was …

This study looked at how a single dose of the experimental drug venglustat is processed and removed from the body in 6 healthy men. Researchers measured the drug and its breakdown products in blood, urine, and stool to understand its metabolism and excretion. The goal was to gath…

This study looked at how different versions of an experimental drug, BMS-986460, are absorbed by the body. It involved 85 healthy adult men and focused on safety and drug levels in the blood. No treatment or disease was studied, so the goal was simply to gather information for fu…

This study looked at how a tablet form of the drug ABBV-722 is absorbed and processed by the body in 11 healthy adults. Researchers also checked whether eating food changes how the drug works. The goal was to gather basic safety and body-processing information, not to treat any d…

This study measured how quickly nicotine enters the bloodstream from three different products: an electronic vapor product (e-cigarette), a nicotine inhaler, and a regular cigarette. Twelve healthy smokers took part. The goal was to understand the nicotine levels each product del…

This study looked at how many people are needed to find most of the mistakes people make when using a medical device called Zeneo®. Researchers tested 60 healthy volunteers, some who knew about auto-injector pens and some who didn't. The goal was to improve future device testing,…

This study looked at how pleasant five different flavors of benzydamine HCl lozenges taste. 60 healthy adults and 60 healthy children each held a lozenge in their mouth for 10 seconds without swallowing, then rated its taste, aftertaste, and texture using a questionnaire with a 7…

This study looked at how taking a new drug called vamifeport with or without food changes the amount that gets into the blood. Twenty-eight healthy adults aged 18 to 60 took part. The goal was simply to measure drug levels, not to treat any disease.

This study aimed to understand how the healthy brain performs the 'check' process—like verifying information to improve performance. Researchers used brain scans (fMRI and EEG) on 51 healthy volunteers while they performed thinking tasks. The goal was to map which brain areas are…

This early-stage study tested a single dose of a new oral medicine called etavopivat in 24 healthy Chinese volunteers. The main goal was to see how the drug moves through and is processed by the body (pharmacokinetics) and to check its initial safety and tolerability. The results…

This was an early-stage study to check the safety of a new drug called BMS-986419 in healthy people. Researchers gave the drug to 74 volunteers to see how their bodies handled it and to carefully measure if it had any effect on their heart rhythm. The main goal was to gather basi…

This study aimed to understand how genes might be linked to substance use disorders and related behaviors. Researchers collected genetic information and measured thinking skills, emotions, and decision-making in 847 adults, including healthy volunteers and people with substance u…