HEALTHY VOLUNTEERS

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months…

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This Phase 3 trial tested Takeda's dengue vaccine (TDV) in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the body's immune response agains…

This study tested a new vaccine designed to protect against two respiratory viruses: RSV and hMPV. It involved 646 healthy adults aged 60 and older who received either the vaccine or a placebo. The goal was to see if the vaccine is safe and triggers a strong immune response, with…

This study tested an experimental RSV vaccine in about 4500 adults aged 60 and older. Half received the vaccine and half received a placebo shot. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be serious in …

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested a new vaccine (MenACYW) to protect against four types of meningococcal bacteria that can cause meningitis and sepsis. Over 1,500 healthy infants and toddlers in India and South Africa received the vaccine alongside routine childhood shots. Researchers compared i…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3 in healthy adults aged 18 to 49. Participants received a single shot of one of several vaccine formulas. The goal was to see if these combination …

This study tested a new investigational vaccine (MenPenta) designed to protect against five types of meningococcal bacteria (A, B, C, W, Y) that cause meningitis and bloodstream infections. Around 1,200 healthy adolescents and adults received either the new vaccine or existing va…

This study tested a new meningitis vaccine (MenACYW) in 840 healthy infants and toddlers. The goal was to see if it works as well as an existing vaccine (Nimenrix) when given as two shots at 6 and 12 months of age. The trial measured immune response and monitored safety to suppor…

This study tested a new dengue vaccine in over 20,000 healthy children aged 4 to 16 years. The goal was to see if two doses could prevent dengue fever caused by any of the four dengue virus types. The vaccine was given as a shot under the skin and compared to a placebo. Results s…

This study tested two different doses of an experimental H7 flu vaccine with an added booster (adjuvant) against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune response and was safe…

This study looked at whether a single booster dose of the MenQuadfi vaccine is safe and effective for healthy toddlers aged 12 to 23 months who had already received a different meningococcal vaccine as infants. The 71 participants in Argentina received one shot and had blood test…

This study tested a single shot of the MenACYW conjugate vaccine (MenQuadfi™) in 447 healthy people aged 12 months and older in Vietnam. The goal was to see how well the vaccine triggers antibodies against four types of meningococcal bacteria and to check for side effects. Partic…

This Phase 1 study tested several versions of a quadrivalent recombinant influenza vaccine, some with an adjuvant, in 210 healthy adults aged 18-30 and 50+. The main goals were to check safety and measure antibody responses against flu strains. Researchers compared different H3 a…

This early-stage trial tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The study compared three different doses of the experimental vaccine to a standard high-dose flu shot. Researchers monitored safety and immune responses over time to see if the new…

This study tested a new meningitis vaccine (MenQuadfi) in 463 healthy adolescents aged 10 to 17. It compared the new vaccine to an existing one (Nimenrix) and also checked if it could be given at the same time as HPV and Tdap-IPV vaccines. The goal was to see if the new vaccine p…

This completed Phase 1 trial tested a new flu vaccine that includes an extra H3 strain, aiming to improve protection against influenza. The study involved 400 healthy adults aged 18-49 and 60+, comparing the new vaccine to standard flu shots. Researchers checked for side effects …

This early-stage trial tested an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV. Healthy adults aged 18 to 49 and 60 years and older received a single injection of the vaccine at different doses. The main goals were to check safety and…

This study tests a new medicine, NNC6022-0001, for the first time in humans. It aims to check the drug's safety, how the body processes it, and how it works. Healthy adults aged 18-55 will receive either a single dose of the drug or a placebo. The results will help decide if furt…

This study tests a new medicine called NNC0537-1482, designed to potentially treat heart failure. It is the first time this drug is given to humans, so healthy volunteers receive a single injection under the skin to check for safety and how the body processes it. Participants are…

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This study tested whether a daily supplement called Immulina, made from Spirulina, can help healthy people fight off upper respiratory viruses like the flu. Researchers measured natural killer cell activity and other immune markers in 492 healthy adults aged 18-59 and 65+. Partic…

This study tested a new medicine called Mim8 for people with hemophilia A, a condition where blood doesn't clot properly. Mim8 is given as a shot under the skin to help prevent bleeding episodes. The trial included 275 healthy volunteers and people with hemophilia A, with or with…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This completed Phase 3 study tested whether a radioactive tracer called [18F]APN-1607 can help detect Alzheimer's disease by lighting up tau tangles in the brain during a PET scan. Researchers compared brain scans of 230 people with Alzheimer's, mild cognitive impairment, and hea…

This early-phase trial tested a new radioactive imaging agent called 18F-LNC1007 in 8 people—some healthy and some with a few small tumors. The goal was to see how the agent moves through the body, how much radiation it gives off, and whether it is safe. Participants received one…

This early-phase trial tested a single injection of a radioactive imaging agent called 68Ga-LNC1007 in 8 adults (healthy volunteers and solid tumor patients). The goal was to check its safety, how it moves through the body, and how well it shows up on scans. The study is already …

This study tested whether a booster dose of the Ebola vaccine (V920) could improve and extend immune protection in 248 healthy adults at risk of Ebola exposure through their jobs. Participants received the primary vaccine and were randomly assigned 18 months later to get a booste…

This early-stage trial tested whether black raspberry confections (like lozenges) could help prevent oral cancer. Sixty-seven healthy volunteers ate different versions of the confection to see which was most acceptable and how it affected genes and chemicals linked to cancer. The…

This study tested a new drug called MAM01 to see if it is safe and could help prevent malaria for at least 4 months. It involved 125 healthy adults and children living in parts of Africa where malaria is common. Researchers gave different doses of MAM01 or a placebo and monitored…

This study tested seven different cosmetic creams to see if they could prevent skin darkening caused by high-energy visible light (like from the sun or screens). 33 healthy adults with fair to medium skin had creams applied to their back before being exposed to a specific blue-vi…

This study tested whether replacing some ingredients in cookies with quinoa could help healthy adults maintain normal blood fat and sugar levels, potentially lowering the risk of obesity and metabolic syndrome. Sixty healthy volunteers ate either a regular cookie or a quinoa-base…

This Phase 3 trial tested a new rabies vaccine (VRVg-2) in 1708 healthy children and adults in Thailand. The goal was to see if it works as well as two existing rabies vaccines when given before exposure to the virus. Participants received a series of shots, and some got a booste…

This study tested a high-dose flu vaccine against a standard-dose one in 2,100 adults aged 60 and older in Japan. The goal was to see if the high-dose version triggers a stronger immune response. Participants received one shot and were followed for 28 days to measure antibody lev…

This study tested whether a high-dose flu vaccine (QIV-HD) works better than the standard-dose vaccine in adults aged 60 and older. Over 1,500 healthy volunteers received either the high-dose or standard shot. Researchers measured immune responses 28 days later to see if the high…

This study looked at whether it's safe and effective to give a high-dose flu vaccine and a Moderna COVID-19 booster at the same time to adults 65 and older. 306 volunteers who had already received two Moderna shots took part. Researchers measured side effects and antibody levels …

This study tested whether a single dose of TRPTI (oleoylethanolamide), a dietary supplement, could improve how the body handles sugar in 19 healthy adults. Participants received either 150 mg, 300 mg, or a placebo in random order, then had their blood sugar and insulin levels mea…

This completed study tested three different food supplements against a placebo in 132 healthy women aged 40-60. Over three months, researchers measured skin firmness, elasticity, density, cellulite visibility, and radiance. The goal was to see if these botanical extracts could im…

This study looked at the best time to give a combination of two sedatives (remimazolam and remifentanil) during a painless stomach scope exam. 342 healthy adults took part to see if changing when the drugs are given reduces side effects like coughing, body movement, and drops in …

This study tested whether combining a low dose of methylphenidate (a drug used for ADHD) with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in the 6-week program. The goal was to se…

This study tested whether a short, 3-minute neck stretch could lower blood pressure in 25 healthy adults. Participants did a gentle stretch on one side of the neck, and researchers measured blood pressure, tissue stiffness, and heart rate changes. The goal was to see if stretchin…

This study looked at whether taking Rhodiola rosea (golden root) for 7 days can improve strength, endurance, and mental focus in healthy adults who already do resistance training. Twenty-seven men and women each tried a low dose, a high dose, a placebo, and a no-capsule control p…

This pilot study explored whether the Feldenkrais Method, a gentle movement and awareness practice, could reduce stress and improve well-being in 24 healthy, sedentary women aged 26-59. Participants attended eight daily 90-minute sessions or served as controls. Researchers measur…

This study tests whether a hands-on physical therapy technique called intercostal mobilization can improve breathing muscle strength, lung function, and walking performance. Researchers will divide 90 healthy, sedentary adults aged 18-30 into three groups: one receiving the real …

This trial tests whether a new generic extended-release tablet containing sitagliptin and metformin works the same in the body as the brand-name version (Janumet XR). Healthy Chinese adults receive a single dose of each tablet, separated by a washout period, under both fasting an…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This early-stage study is testing a new drug, Alpha-0261, for the first time in people. The goal is to see if it is safe and how the body processes it. About 60 healthy adults will receive a single dose of the drug or a placebo. No treatment benefit is expected; the study is pure…

This early-stage trial tested a new drug called CDP1, which is a close copy of the cancer drug Erbitux, in 84 healthy male volunteers. The goal was to see how the body handles CDP1, whether it causes side effects, and if it triggers an immune response. The results will help decid…

This study tested whether wrapping an elastic band around the upper arm for two minutes can immediately improve arm stability and explosive power. Twenty-eight healthy adults were randomly assigned to receive either the real band or a fake sham band. Their performance was measure…

This early-stage study tested a single dose of TRL345, an antibody designed to fight cytomegalovirus (CMV), in 16 healthy adults. The main goal was to check safety and how the body processes the drug. Results will help plan future studies in transplant patients who are at high ri…

This completed Phase 1 study tested whether a single dose of balinatunfib affects the heart's electrical activity in 48 healthy adults aged 18 to 55. Participants received balinatunfib, a placebo, and an active control (moxifloxacin) in a crossover design. The main goal was to me…

This completed study looked at how much of the drug KarXT (xanomeline/trospium chloride) gets into the breast milk and blood of 10 healthy women who were breastfeeding. The goal was to measure drug levels and estimate how much an infant might be exposed to. The results will help …

This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients …

This early study tested a new oral version of the Parkinson's drug levodopa/carbidopa designed to release the medication slowly over time. Six healthy volunteers took the drug to see if it could keep steady levels in the blood. The goal is to reduce the 'on-off' motor fluctuation…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

This completed Phase 1 study tested whether giving growth hormone (Norditropin) through a small pump under the skin could improve immune function in healthy men aged 25 to 50. Participants received either growth hormone or a placebo for up to 4 weeks, with frequent blood and urin…

This completed study looked at how vitamin C moves through the body in healthy adults. Researchers placed 23 volunteers on a low-vitamin C diet, then gave them increasing doses of vitamin C by mouth and IV. They measured vitamin C levels in blood and urine to see how water intake…

This completed Phase 1 trial tested whether the experimental drug ziresovir affects the heart's electrical activity in 34 healthy adults. Participants received different doses of ziresovir, a placebo, and an active control (moxifloxacin) to compare effects. The main goal was to m…

This study looks at how aging cells in the skin respond to small injuries. Researchers will take small skin samples from healthy adults aged 20-39 or 70+ to see if older people have more senescent (non-replicating) cells around wounds. The goal is to better understand aging and a…

This early-phase trial tested the safety and tolerability of a drug called X842 in 39 healthy adults. Participants received either single or multiple doses of X842 to see how the body handles it and what side effects may occur. The study is complete and does not aim to treat any …

This study tested a new biosimilar drug called HD204 against the original Avastin in 119 healthy men. The goal was to see if the body processes both drugs the same way. Participants received a single dose, and researchers measured drug levels and safety. The trial is complete, bu…

This study looks at whether the hormone progesterone changes how muscles build protein after resistance exercise. Twenty healthy women aged 18-30 will take either progesterone pills or a placebo, then do leg exercises. Researchers will measure muscle growth using biopsies and blo…

This study tested two drugs that act on the body's endocannabinoid system—nabilone and CP-945,598—to see how they affect insulin production and sensitivity. Forty-five healthy men aged 21 to 55 took part in four visits, each receiving a different drug combination. The goal was to…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study aims to collect reference measurements of the spine and pelvis from 161 healthy adults using a low-dose X-ray system called EOS. By understanding what a normal, pain-free spine looks like, researchers hope to better diagnose and treat people with back pain. Participant…

This study looked at how different types of meat (minimally processed vs. further processed) combined with different diet patterns affect blood markers related to heart disease risk. Sixty healthy adults followed one of four diet plans for a set period. Researchers measured subst…

This study aims to find better ways to measure what people eat by looking for biomarkers in blood, urine, hair, and fat. Fifty-nine healthy men will eat carefully controlled diets with different amounts of meat, fish, and soda for 12 weeks. Researchers will then check if changes …

This completed Phase 1 trial enrolled 30 healthy adults aged 18-50 to compare how the body absorbs and clears two antibody treatments given as a single injection under the skin: TAK-881 and HyQvia. Participants stayed at the clinic for 8 days and had follow-up visits up to Day 85…

This study looked at whether a 12-week exercise program designed around students' personal interests (like team games or fitness challenges) could help them exercise more regularly and improve their physical fitness compared to standard physical education. Over 500 college studen…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This early-phase trial tested the safety and tolerability of a new drug called EI1071 in 58 healthy volunteers. Participants received either single or multiple doses of the drug or a placebo. The study aimed to understand how the body processes the drug and whether it causes any …

This early-stage study tested the safety and tolerability of a new drug called ITI-333 in 32 healthy adults aged 18 to 45. Participants received either the drug or a placebo once daily for 14 days. The goal was to measure how the drug moves through the body and check for any side…

This early-stage study tested the safety and how the body processes a new drug called nacresertib in 93 healthy adults. Participants received either single or multiple doses of the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not…

This study looked at how a new drug called OPC-167832 is processed by the liver when taken with other common medicines. Twenty-four healthy adults took part to see if certain drugs slow down or speed up the breakdown of OPC-167832. The goal was to gather safety information, not t…

This completed Phase 1 trial studied how a new drug called CS0159 behaves in the body when taken with a high-fat meal or with other drugs (rifampicin and itraconazole). Thirty-two healthy adults aged 18–45 participated. The goal was to measure drug levels and safety, not to treat…

This study in 200 healthy Pakistani adults looked at whether a common gene variation (CYP2C9*3) changes how well ibuprofen works for pain after a molar tooth extraction. Participants took ibuprofen or a placebo, and researchers measured pain levels and side effects. The goal was …

This completed Phase 1 trial studied how two drugs, roflumilast (used for COPD) and sitagliptin (used for diabetes), affect blood sugar and gut hormones in 29 healthy volunteers aged 21-55. Participants received each drug alone, together, or a placebo, then drank a nutritional sh…

This study tested whether healthy adults can safely digest and absorb protein from purple bacteria. Twelve participants ate a dairy product with or without purple bacteria, and researchers measured amino acid levels in their blood over four hours. The goal was to see if purple ba…

This early-stage study tested the safety of a new drug called MF-300 in 100 healthy adults. Participants received either a single dose or multiple doses to see how the drug moves through the body and what side effects occur. The goal was to gather safety information, not to treat…

This study looked at how doing isometric exercises (holding a muscle still) at different knee angles affects balance, body awareness, and daily movements in healthy adults. Thirty people aged 18-26 did an 8-week training program. The goal was to find which knee angles work best f…

This early-stage study tested the safety of a new drug called MT-701 in 46 healthy adults aged 19 to 55. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, …

This study tested a special MRI technique called T1rho to measure hip cartilage in 31 healthy volunteers. The goal was to see if the method gives consistent results and to establish normal values. This could help doctors detect early signs of hip osteoarthritis, a common and pain…

This study looked at whether taking the acid-reducing medicine famotidine changes how the body processes a new drug called afimetoran. It involved 32 healthy adults and used a crossover design to compare drug levels with and without famotidine. The goal was to gather safety and d…

This study tested how food and a common stomach-acid drug (rabeprazole) affect the amount of an experimental medicine called ZN-A-1041 in the blood. Twenty-four healthy adults took the drug under different conditions to measure absorption. The goal was to learn how to best take t…

This study looked at how a common seizure medicine, carbamazepine, changes the amount of mirdametinib in the blood. 36 healthy adults took both drugs by mouth. The goal was to understand how the body processes mirdametinib when taken with carbamazepine, which can help doctors dec…

This study looked at how healthy men absorb, break down, and get rid of a drug called JNT-517. Eight men took a single dose with a radioactive tracer so scientists could track it in blood, urine, and stool. The goal was to understand the drug's path through the body, not to treat…

This study measured how much of a brain protein called PDE10A is occupied by a single dose of TAK-063 in 13 healthy adult volunteers. Researchers used special brain scans (PET scans) to see the drug's effect at 3 and 23 hours after taking it. The goal was to understand how the dr…

This early-stage study tested a single dose of the experimental drug selonabant in 40 healthy adults aged 18 to 30. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side…

This completed Phase 1 study looked at how oxycodone moves through the body when given as a nasal spray or an oral solution. Eight healthy volunteers received a single dose of each form on separate days. The goal was to compare drug levels in the blood and any side effects, to he…

This early-stage study tested a new oral drug called IPG1094 in 76 healthy adults aged 18 to 50. The main goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. This trial …

This early-stage study tested a new oral drug called AN2-502998 in 72 healthy adults aged 18 to 55. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug le…

This early-phase study tested a tablet form of ABBV-722 in 11 healthy adults to see how the body processes it and whether food changes its absorption. Participants took a single dose, and researchers measured drug levels in the blood and monitored for side effects. Since this is …

This study was the first time a new drug, VIS954, was given to humans. The main goal was to see if it is safe and how the body handles it. 54 healthy adults received either the drug or a placebo. Researchers monitored for side effects and measured drug levels in the blood.

This study tested a non-invasive technique called transauricular vagus nerve stimulation (taVNS) in 44 healthy adults. Participants received a gentle electrical pulse to the ear for 60 minutes to see how it changes brain activity and the body's ability to handle pain. The goal wa…

This study looked at whether taking creatine and L-arginine together, just once, can improve short bursts of exercise and mental reaction time in healthy, active men. Eighteen men tried each supplement alone, together, or a placebo in random order. They did sprint tests, jump tes…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This completed phase 1 trial tested the safety of ARGX-213 in 88 healthy adults aged 18 to 65. Participants received either the drug or a placebo, and researchers monitored side effects, drug levels in the blood, and immune responses over up to 21 weeks. The study aims to underst…

This early-stage trial tested a single dose of the experimental drug ENX-104 in 12 healthy volunteers. The goal was to see how the body absorbs the drug when given as a liquid or a tablet, and whether a high-fat meal changes absorption. No treatment for any disease was studied; t…

This study looked at how many people are needed to find usability errors in the Zeneo® auto-injector pen, a device used for severe allergic reactions. 60 healthy volunteers used a demo version during a simulated anaphylactic shock. The goal was to improve device design by catchin…

This early-phase trial tested the safety and tolerability of a new drug called SEP-631 in 120 healthy adults aged 18 to 60. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. Since this study was done in healthy v…

This study tested a new pill that combines two drugs (zanubrutinib and sonrotoclax) used to treat blood cancers. 24 healthy adults took the pill to see how well it is absorbed by the body, both with and without food. The goal was to compare the combination pill to taking the two …

This completed Phase 1 trial tested how two drugs, epaminurad and C2406, interact when taken together in 18 healthy adults aged 19 to 50. Researchers measured drug levels in the blood and checked for side effects. The goal was to see if combining them is safe and how the body pro…

This early-stage trial tested the safety and tolerability of an experimental drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers. Researchers gave the drug as single or multiple daily doses and monitored participants closely for side effects, blood levels, and lab …

This early-stage study tested two different injection devices for delivering the drug amlitelimab under the skin. It involved 212 healthy adults aged 18 to 55. The goal was to see if the devices deliver the same amount of drug and are safe, not to treat any disease.

This study looked at the long-term safety of tafenoquine, a drug used to prevent malaria. 600 healthy volunteers took either tafenoquine or a placebo daily for three days, then weekly for 51 weeks. Researchers monitored eye health and other side effects to see if the drug is safe…

This study looked at whether L-lysine, a common amino acid, changes levels of aldosterone and cortisol—hormones that control salt balance and stress. Twenty healthy men took L-lysine or a placebo for 13 days, then switched. Researchers measured hormone responses to standing, a dr…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study looked at whether a new drug called EB-1020 has abuse potential in 80 healthy adults who use stimulants recreationally. Participants received single doses of EB-1020, d-amphetamine, or placebo, and rated how much they liked the drug. The goal was to see if EB-1020 prod…

This early-phase trial tested the safety of a new drug called BB-025, designed to reverse the effects of another experimental drug, BB-031. 72 healthy volunteers received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The main goal was to check…

This study looked at how eating too much at different times of day affects inflammation and metabolism in healthy adults. Researchers measured over 50 inflammatory markers and 500 metabolites in blood samples. The goal was to understand if eating late in the evening is worse for …

This study tested whether taking a nap in different environments, including a special rest module called SOMBOX, helps healthy adults stay alert and drive better. Forty participants each tried four conditions: napping in different settings or resting without napping. Researchers …

This study tested a new device called E-Celsius, which is a pill you swallow that measures your body temperature as it travels through your digestive tract. Researchers compared its readings to standard thermometers placed in the rectum or esophagus in 22 healthy volunteers. The …

This early-phase study tested a single injection of ORKA-001 in 24 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The main goal was to check for side effects and changes in vital sign…

This completed Phase 1 study looked at how the cancer drug repotrectinib changes the levels of other medications in the body. Thirty healthy adults took repotrectinib along with several common drugs (metformin, digoxin, rosuvastatin, bupropion, flurbiprofen, and omeprazole). The …

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database for a new gait index called Ker-EGI Kids. Researchers placed 28 stickers on each child's legs to record muscle activity while they walked. The goal is to establish what normal …

This completed study measured oxygen and carbon dioxide levels in the throat of 14 healthy volunteers while they received oxygen through a nasal cannula, face mask, or standard non-rebreather mask. The goal was to understand how different delivery methods affect gas composition i…

This study tested whether a non-invasive imaging technique can measure tiny blood vessels (microcirculation) during brief weightlessness on parabolic flights. Sixteen healthy volunteers were observed during 21-second periods of zero gravity. The goal was to understand how the car…

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The drug is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the dru…

This study tested a new drug called atumelnant in 21 healthy adults from Japanese and Caucasian backgrounds. The goal was to see how the drug moves through the body and if it is safe. Participants took the drug or a placebo by mouth once daily. This early-stage study does not aim…

This study compared two different pill forms of the drug centanafadine in 62 healthy adults. The goal was to see how well each form releases the drug into the body. Results will help decide which version to use in future studies.

This study tested a new ultrasound technique to measure blood flow inside the shin bone of 30 healthy men. Researchers used simple exercises and pressure cuffs to see how bone blood vessels react. The goal is to develop a tool that could one day help monitor bone health in astron…

This study tested four different nicotine pouches (tobacco-free and tobacco-containing) in 27 healthy adults who regularly use snus or nicotine pouches. Researchers measured how much nicotine entered the bloodstream and how much was left in the pouch after 20 minutes of use. The …

This early-stage study tested the safety and tolerability of Ginkgolide B injection in 36 healthy adults aged 18 to 45. Participants received single or multiple doses to see how the drug behaves in the body and what side effects occur. The goal was to gather safety data, not to t…

This early-stage study tested the safety and how the body handles two experimental drugs (GEH200521 and GEH200520) given together to 22 healthy adults. The goal was to see if the drugs are safe and how they spread through the body using PET scans. This study does not aim to treat…

This early-stage study tested the safety of a new drug, NAV-240, in 24 healthy adults. Participants received either the drug or a placebo to see what side effects might occur. The goal was to gather initial safety information, not to treat any disease.

This completed Phase 1 study tested a single dose of teprotumumab (Tepezza) in 20 healthy Chinese adults. The goal was to see how the drug moves through the body and check for side effects. Participants received either the drug or a placebo by IV, and researchers measured drug le…

This Phase 1 study tested the safety and tolerability of a single intravenous dose of AK1967 (Procizumab) in 24 healthy male volunteers. AK1967 is an antibody that blocks a protein called DPP3, which may worsen blood pressure drops during cardiogenic shock. The study only looked …

This study looked at how a new drug called KarXT interacts with three common mood stabilizers (lithium, valproic acid, and lamotrigine) in 133 healthy adults. Researchers measured drug levels in the blood and checked for side effects. The goal was to understand if these drugs aff…

This study looked at how genetic differences affect the activation of enalapril, a common blood pressure medication. Researchers gave 21 healthy volunteers enalapril for a week and measured drug levels in their blood. The goal was to see if a specific gene variant (G143E) changes…

This study tested whether gentle electrical stimulation during naps can increase certain brain waves linked to emotional health. 72 healthy adults who nap regularly took part. Researchers measured brain activity, mood, and alertness to see if the stimulation helped. The goal was …

This study looked at how brief periods of weightlessness during parabolic flights (like those used to train astronauts) affect the brain's memory and navigation centers. Twenty-four healthy volunteers underwent brain scans and cognitive tests before and after flying. The goal was…

This study tested a single injection of a new drug (NNC0194-0499) for non-alcoholic fatty liver disease in 33 people with various degrees of liver impairment and healthy volunteers. The goal was to see how the liver processes the drug and whether it is safe. Results will help det…

This early-stage study tested a new tablet (HD-P023) against taking two diabetes drugs separately in 40 healthy adults. Researchers measured how the drugs move through the body and checked for safety. The goal was to see if the combination pill works similarly to the separate med…

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used safe brain scans, EEG, and eye-tracking tests at three ages. The goal was to understand normal development and how early experiences shape the brain. This…

This completed Phase 4 study tested whether an updated COVID-19 vaccine (mRNA-1273.712) affects heart muscle in healthy people aged 12 to 30. Researchers measured a heart enzyme called troponin in 1,000 participants who received either the vaccine or a placebo. The goal was to se…

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. 80 healthy young adults were split into two groups: one walked outdoors in nature, the other walked indoors in a…

This study tested how well risankizumab enters the body when given through an on-body injector compared to a standard prefilled syringe. 260 healthy volunteers received the drug by one of the two methods. Researchers measured drug levels in the blood and checked for side effects …

This early-stage trial tested the safety and tolerability of an experimental drug called AZD1163 in 108 healthy volunteers. Participants received either the drug or a placebo by IV or injection, and researchers monitored side effects and how the drug moved through the body. Since…

This completed Phase 1 study tested how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18-55. Participants took five doses of the drugs and underwent a bronchoscopy to measure drug levels in lung fluid. The goal was to un…

This completed Phase 1 study looked at how the drug golcadomide is processed in the body of people with moderate or severe liver impairment compared to healthy volunteers. 29 adults received a single dose, and researchers measured drug levels and safety. The goal is to understand…

This early-stage study tested the safety and how the body handles two experimental antibodies (AZD5396 and AZD8076) in 61 healthy adults. Participants received the antibodies through injections followed by a mild electrical pulse to help the body produce them. The goal was to che…

This completed Phase 1 study tested an experimental drug called BMS-986460 in 85 healthy adult men. The goal was to see how safe different pill versions are and how the body processes them. No treatment was given for any disease—this was purely an early safety and drug-level stud…

This study tested how well vitamin A is absorbed from fortified bouillon cubes compared to an oil-based supplement. Fifty-eight healthy women consumed different vitamin A formulations in broth, and researchers measured vitamin levels in their blood. The goal is to see if adding v…

This completed phase 1 trial enrolled 12 healthy adults to see how a single dose of the experimental schizophrenia drug SEP-380135 interacts with quinidine, a medicine that blocks a key liver enzyme. Researchers measured drug levels in the blood and monitored safety. The goal is …

This study tested a new way to collect fluid from the skin using a tiny microneedle patch. Researchers compared samples from 20 healthy volunteers and people with eczema (atopic dermatitis) to see how much fluid could be collected and how well it was tolerated. The goal was to le…

This early-stage trial tested the safety of a new drug called KINE-101 in 40 healthy volunteers. Participants received a single dose either through a vein or under the skin. The main goal was to check for side effects and how the drug moves through the body. No treatment benefit …

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This study looked at how a new drug called linaprazan glurate interacts with common antibiotics (clarithromycin, amoxicillin) and bismuth in 56 adults. Some participants were healthy and H. pylori-negative, while others had H. pylori infection. The goal was to measure drug levels…

This early-stage study tested the safety of a new drug called KINE-101 in 24 healthy adults. Participants received daily intravenous doses for a week at different strength levels. The goal was to check for side effects and how the drug moves through the body, not to treat any dis…

This study looked at whether giving the drug zilucoplan through a prefilled syringe or an auto-injector works the same in the body. It involved 14 healthy adults aged 18 to 55. The goal was to compare how the drug is absorbed and to check safety, not to treat any disease.

This study tested two different tablet forms of an experimental drug called UCB0022 in 14 healthy adults. The goal was to see how well each form is absorbed into the body and to check for any safety issues. Participants took a single dose of each tablet on separate occasions, and…

This study looked at how collagen from drinks gets into the blood. Twenty-five healthy men drank different collagen products or a placebo. Blood samples were taken before and up to 4 hours after drinking to measure collagen building blocks. The goal was to see which products are …

This completed phase 1 trial studied how etavopivat, a potential new medicine for sickle cell disease and thalassemia, affects the heart's electrical activity. Thirty-three healthy adults received single doses of etavopivat, a placebo, or an approved heart medication (moxifloxaci…

This completed Phase 1 trial studied how a single dose of the experimental drug OPC-167832 is eliminated from the body. Eight healthy men took the drug, which was tagged with a tiny amount of radioactivity, and researchers measured how much came out in urine and stool. The goal w…

This early-stage study tested a new experimental drug, NNC0113-6856, in 70 healthy men to see if it is safe and how the body processes it. Participants received either a single oral dose or an injection into the vein. The goal was to gather initial safety data and measure drug le…

This study used special PET and MRI scans to look at brain activity in 27 men with autism, Fragile X syndrome, or no condition. The goal was to measure a brain chemical called glutamate, which helps nerve cells communicate. Researchers hope this will reveal how brain signaling di…

This study looked at how healthy adults' brains handle the decision to double-check their work. Using brain scans (fMRI and EEG), researchers aimed to pinpoint which brain areas are active during checking tasks. The goal is to better understand compulsive checking in conditions l…

This early-stage study tested a new drug, AJ302-IM, in 57 healthy adults to see if it is safe and how the body processes it. Participants received a single injection of either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not …

This completed Phase 1 study tested a single dose of the drug etavopivat in 24 healthy Chinese adults. Researchers measured how much of the drug got into the blood and how long it stayed, as well as any side effects. The goal was to gather basic safety and drug-processing informa…

This study tested two different versions (a tablet and a capsule) of an experimental medicine called NDec, which is being developed for sickle cell disease. 44 healthy adults each took a single dose of both forms to see how the body absorbs them. The goal was to compare the two f…

This study checked if a wearable motion sensor (BTS G-sensor) can accurately measure how high people jump. Twenty-nine healthy women aged 18-35 did countermovement jumps while wearing the sensor and using a smartphone app. The goal was to see if the sensor gives results similar t…

This completed Phase 1 study tested how well the drug risankizumab (SKYRIZI) enters the body when given by a prefilled pen compared to a prefilled syringe. Fifty-nine healthy adults received a single injection, and researchers measured drug levels and side effects. The goal was t…

This early-stage trial tested a single injection of the experimental drug NNC0582-0001 in 56 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo and were followed for a year. The study is complete, but it was not d…

This early-stage trial tested the safety and tolerability of a new drug called AG-181 in 88 healthy volunteers. Researchers gave single or multiple doses to see how the body processes the drug and whether it causes any side effects. The study also looked at how food affects drug …

This study tested whether exposure to special light lamps at 5am could help people stay alert and think clearly after a full night without sleep. Researchers compared two different light devices to no light at all in 18 healthy adults. The goal was to see if light could reduce fa…

This early-stage study tested two new quick-melt versions of the stomach acid drug vonoprazan in 25 healthy adults. The goal was to see how well the body absorbs these new forms, taken with or without water, compared to the standard tablet. The results help determine if these eas…

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers a…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. Researchers gave 66 healthy adults and people with depression either the steroid or a placebo for three days, then used memory tests and advanced MRI s…

This early-stage study tested a new drug called TAK-004 in 121 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as an injection under the skin. The study did not aim to treat any disease, but to gather important…

This completed Phase 1 trial tested the safety and how the body absorbs VRG50635 in 22 healthy adults aged 19 to 55. Participants received either the drug or a placebo. The study focused on side effects and drug levels in the blood, not on treating any disease.

This completed Phase 1 trial studied how a single 16 mg dose of selatogrel is absorbed and processed in the body of 32 healthy volunteers (16 Japanese and 16 Caucasian). The study did not aim to treat any condition, but to gather safety and drug-level data. Participants stayed in…

This early-stage study tested the safety and tolerability of a new drug, LAD603, in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to see how the body processes it and if it causes side effects. The goal was to gather initial safety data, not …

This study tests how the experimental drug cagrilintide, being developed for weight management, is processed by the body in people with different levels of liver function. It involves 32 participants, including those with liver impairment and healthy volunteers. The goal is to se…

This early-stage study tested a single dose of the experimental drug NRS 033 in 24 healthy adults aged 18 to 55. The main goal was to check safety and how the drug moves through the body. No treatment was given for any disease, so this study does not offer any direct health benef…

This study looked at how giving a single shot of the experimental drug KAI-9531 in different places (upper arm, thigh, or belly) changes the amount of drug that gets into the blood. It involved 51 healthy volunteers with a range of body sizes. The goal was to find the best inject…

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This early-stage trial tested the safety of a new drug, VNRX-7145, in 83 healthy adults aged 18 to 45. Participants received either a single dose or multiple doses over 10 days to see how the body handles the drug and if any side effects occur. The study is complete and focused o…

This completed Phase 4 study looked at how much deucravacitinib (SOTYKTU®), a drug for plaque psoriasis, passes into breast milk. Eight healthy lactating women took a single dose, and researchers measured drug levels in their milk and blood. The goal was to estimate how much of t…

This early-stage study tested a single dose of the experimental drug EA5 in 28 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either EA5 or a placebo, and neither they nor the doctors knew who got which. The goal …

This early-phase trial tested the safety and tolerability of a new drug called MT-501 in 72 healthy adults aged 19 to 55. Participants received either single or multiple oral doses of MT-501 or a placebo. The main goal was to monitor for side effects and how the drug moves throug…

This completed early-phase study gave a single oral dose of ENX-104 to 10 healthy volunteers to check its safety, how the body processes it, and how well it binds to D2/D3 receptors in the brain. The main goal was to track any side effects. Since this was a small, first-in-human …

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This study tested whether digital nutrition workshops and a recipe collection could help hospital employees adopt a more plant-based diet. 64 participants were split into two groups: one received intensive digital training (about 2 hours per week), the other got lighter support (…

This study tested two different versions of an inhaled drug (TPIP) in 42 healthy adults to see how much of the drug gets into the blood. Participants inhaled a single dose of each version on separate days. The results help researchers understand which formulation works better for…

This study looked at how two common drugs (phenytoin and itraconazole) change the way the body handles BGB-16673. It involved 37 healthy adults aged 18-65. The goal was to measure drug levels in the blood, not to treat any disease.

This early-phase study tested a drug called TAK-123 in 10 healthy Japanese men to see how the body absorbs and processes it, and whether it causes any side effects. The drug was given as an infusion, and researchers measured levels of its components in the blood. Since this was a…

This study used brain scans (fMRI) to see what happens in the brain when healthy people meditate or are hypnotized. 100 volunteers completed tasks and reported their experiences. The goal is to understand how these practices change self-awareness, which could help explain their h…

This completed Phase 1 trial studied 28 healthy adults to see how food changes the absorption of a new prolonged-release version of vamifeport, an experimental drug. Participants took a single dose of the drug either with or without food, and researchers measured drug levels in t…

This study looked at how complex our movements are by measuring finger-tapping patterns in 60 healthy volunteers. The goal was to understand normal sensorimotor behavior and see if these measurements could be useful in future clinical settings. No treatment was given; it was pure…

This study looked at 50 healthy adults to see if changing arm position makes veins in the armpit and collarbone area show up bigger on ultrasound. The goal was to find the best arm position for easier and safer vein access. Results help guide doctors when placing central lines.

This early-stage study tested a new drug called BMS-986419 in 74 healthy volunteers to see if it is safe and how the body processes it. The study also checked if the drug affects the heart's electrical activity. Since participants were healthy, the goal was only to gather safety …

This early-stage study tested how well healthy adults tolerate a new form of immune globulin (TAK-881) given under the skin with an enzyme that helps it spread. Sixty-four participants received different doses to see if they could complete the infusion without side effects. The g…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This early-stage study tested a new medicine called NNC0581-0001 in 48 adults, including healthy volunteers and people with fatty liver (hepatic steatosis). The main goal was to check safety and how the drug moves through the body after a single injection under the skin. Particip…

This completed Phase 1 trial tested the safety, tolerability, and heart effects of the drug BMS-986278 in 42 healthy adults. Participants received either the drug, a placebo, or a control medication to check for any impact on heart rhythm. The study aims to ensure the drug is saf…

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part to help understand if liver problems change drug levels. The results will guide dosing for pa…

This study looked at how cooling the brain changes its activity in healthy adults. Participants wore a cooling cap while researchers measured brain responses using transcranial magnetic stimulation (TMS). The goal was to better understand brain plasticity, not to treat any diseas…

This study tested a new biosimilar drug (MB04) against two versions of Enbrel in 141 healthy men. The goal was to see how the drugs move through the body and if they cause side effects or immune reactions. Participants received a single dose and had blood samples taken over sever…

This study involved 120 healthy volunteers (60 adults and 60 children) who tasted five different flavored lozenges for 10 seconds each. They then answered a questionnaire about taste, aftertaste, and texture using a simple smiley-face scale. The goal was to see which flavor peopl…

This study looked at how the drug belumosudil affects certain proteins in the body that process other medications. Fifty-two healthy men took belumosudil along with other drugs to see how their bodies handled them. The goal was to gather safety and interaction information, not to…

This early-stage study gave a single dose of a radioactive-labeled version of the experimental breast cancer drug amcenestrant to 6 healthy postmenopausal women. The goal was to track how the drug is absorbed, broken down, and eliminated from the body. The results will help guide…

This study tested a new method to measure how hard a person is breathing while using a non-invasive ventilator (a mask that helps with breathing). Researchers used a brief airway occlusion (a short pause in airflow) to estimate breathing effort in 12 healthy volunteers. If proven…

This early-stage study tested a single 4 mg dose of the drug cenerimod in 20 healthy volunteers (10 Japanese and 10 Caucasian). The goal was not to treat any disease but to see how safe the drug is and how the body absorbs and breaks it down. Participants stayed in the clinic for…

This early-stage study tested how taking rilzabrutinib with or without food, and in different pill forms, changes the drug levels in the body. Twenty-four healthy volunteers each received a single dose. The goal was to find the best way to give the drug in future trials, not to t…

This early-stage study tested two different pill versions of an experimental drug called PF-07976016 in 12 healthy adults. The main goal was to measure how much of the drug gets into the blood and how the body processes it. This type of study helps researchers choose the best for…

This study tested whether a dietary supplement made from silver fir branches (Belinal®) is safe for the liver and kidneys. Fifteen healthy adults took 900 mg daily for 14 days, and researchers measured blood markers of liver and kidney function. The goal was to see if the extract…

This early-stage study tested two different versions of the experimental drug amlitelimab in 32 healthy adults. The goal was to see how the body absorbs and processes each version and to check for any safety issues. Participants received a single injection and were monitored for …

This completed Phase 1 study tested whether a new version of the drug dupilumab works the same in the body as the current version. 182 healthy adults aged 18-65 received a single injection of either the new or current product. The goal was to compare how the drug is absorbed, not…

This early-phase trial tested the safety and tolerability of a single dose of ALN-AGT01 RVR in 42 healthy adults. Participants received either the drug or a placebo by injection. The study is complete and focused on side effects and how the drug moves through the body.

This early-stage study gave a single dose of the experimental drug venglustat to 6 healthy men to see how it is processed and eliminated from the body. Researchers measured radioactivity in urine, feces, and blood to map the drug's breakdown and excretion. The goal was to underst…

This early-stage trial tested the safety and tolerability of a new drug called SAR441344 in 56 healthy adults. Participants received either the drug or a placebo by injection or infusion. The study did not aim to treat any disease, but to gather initial safety data.

This early-stage study tested different versions of the drug povetacicept in 136 healthy adults to see how well the body absorbs each form. The goal was to compare the drug's bioavailability and check that different presentations work the same way. Researchers also monitored safe…

This study looked at how much nicotine gets into the blood and how strong the urge to smoke is when using blu disposable e-cigarettes compared to regular cigarettes. Twenty adult smokers who smoke at least 10 cigarettes a day took part. They used both their usual cigarette and di…

This study tested whether a new tablet form of Magne-B6 releases magnesium and vitamin B6 into the body as well as the current liquid version. Twenty-four healthy adults took both forms in random order and had their blood and urine levels measured. The goal was to see if the tabl…

This study tested a new version of the allergy drug fexofenadine (Allegra) to see if it is absorbed well when taken with or without water. 25 healthy adults each received six different treatments in random order. The goal was to compare the new tablet to the standard coated table…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults aged 65 and older who received the 2020-2021 flu vaccine. The samples were sent to experts at the WHO, CDC, and FDA to help decide which flu strains to include in future vaccines. T…

This study looked at whether a 12-week strength and power training program could improve movement patterns, physical fitness, and leg strength in Chinese college dancesport athletes. Thirty healthy female dancers were split into two groups: one did strength training three times a…

This study looked at how quickly and how much nicotine gets into the blood from e-cigarettes, a nicotine inhalator, and regular cigarettes. Twelve healthy smokers took part, and researchers measured nicotine levels and withdrawal symptoms. The goal was to understand the nicotine …

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults 65 and older after they received their seasonal flu vaccines. The samples were sent to health authorities to help decide which flu strains to include in future vaccines. The study d…

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults. Researchers used brain scans to see how much of the drug attached to a specific receptor (5-HT2A) in the brain. They also checked safety, side effects, and how the drug moves throug…

This early-stage study tested a single dose of the drug maribavir in 24 healthy adults—12 of Japanese descent and 12 of non-Hispanic Caucasian descent. The goal was to see if the drug behaves differently in these groups and to check safety. Participants took different doses to un…

This early-stage trial tested the safety and tolerability of a new drug called SIM0278 in 60 healthy Chinese adults. Participants received either a single or multiple doses of the drug or a placebo via injection. The main goal was to check for side effects and how the drug moves …

This early-stage study tested several new versions of insulin lispro in 54 healthy volunteers to see how quickly the body absorbs and clears them, and whether they are safe. Participants received one or more injections, and researchers measured insulin levels in the blood. Becaus…

This study looked at whether being in labour affects how quickly a light meal (flavoured yoghurt) leaves the stomach. Researchers used ultrasound to measure stomach emptying in 43 women: those in labour with or without epidural, pregnant women not in labour, and non-pregnant wome…

This study involved 47 people with drug-resistant epilepsy and healthy volunteers. Researchers recorded brain activity simultaneously using implanted electrodes (intracranial EEG) and non-invasive scans (MEG or fMRI). The goal was to better identify seizure-causing brain areas an…

This completed Phase 1 study looked at how two different tablet forms of the drug BGB-43395 are absorbed in 51 healthy adults aged 18-65. It also checked whether taking the drug with food changes absorption. The goal was to gather basic information, not to treat any disease.

This pilot study tested whether adding a motivational boost to mental imagery or watching exercise videos could improve lower back and pelvic strength in healthy adults. Forty participants were split into four groups: mental imagery, watching videos, or each combined with motivat…

This study gave 10 healthy volunteers a single dose of 10 common drugs at the same time to see how their bodies break them down. The goal was to measure key factors like drug levels and half-life to understand each person's unique metabolic profile. The results could help persona…

This study looked at how a common gene variation (TaqIB) affects the function of HDL, or 'good' cholesterol, after a meal. Researchers compared two groups of healthy men with different versions of this gene to see how well their HDL could remove cholesterol from cells. The goal w…

This early-stage study tested two different tablet forms of the drug rilzabrutinib in 28 healthy adults. The goal was to see how well each form is absorbed by the body, both with and without food. Participants took a single dose of each tablet in a random order, with a day off be…

This study used fMRI to watch brain activity in 36 healthy adults while they performed eye movement tasks. The goal was to identify which brain regions help adjust eye movements (saccades) to keep them accurate. Participants completed tasks where targets jumped in predictable or …

This study looks at why some people with chronic balance problems develop very fast eye movements that help them see clearly when moving their head. Researchers tested 12 patients and 12 healthy volunteers using virtual reality and head movements. The goal was to understand what …

This completed study in 76 healthy volunteers used brain scans (fMRI) and mild electrical stimulation (GVS) to explore how different types of feedback—like social or monetary cues—influence decision-making. The goal was to map the brain networks involved, with the hope of applyin…

This study tested a new micro-needle for giving TB skin tests, comparing it to the standard method in 59 healthy volunteers. The goal was to see if the new needle makes the test easier to give and more consistent. Researchers also tested a device to read the skin reaction without…

This study looked at how healthy people remember experiences from daily life or virtual reality. Using brain scans (fMRI), researchers measured brain activity during recall to understand which areas are involved. The goal was to learn more about memory and attention, not to test …