HEALTHY VOLUNTEERS

This study tests a new vaccine (PCV21) in healthy infants to see if it safely helps their bodies build defenses against 21 types of pneumococcal bacteria, which can cause serious illnesses like pneumonia and meningitis. About 1,092 babies will receive either the new vaccine or a …

This early-stage trial tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and can boost the body's immune defenses against several coronavirus variants. Participants receive one injection and are monitored for side eff…

This study tests a new vaccine that aims to protect children against five types of meningococcal bacteria (A, B, C, W, Y) that cause meningitis and bloodstream infections. Researchers will give the vaccine to healthy children aged 2-9, toddlers 12-15 months, and infants 2 months …

This early-stage study tests a new vaccine (VXB-241) designed to protect against two viruses that cause serious lung infections in older adults: RSV and HMPV. About 144 healthy adults aged 60-83 (and some younger adults) will receive one dose of the vaccine at different strengths…

This study tests a new vaccine designed to protect against four types of meningococcal bacteria that can cause meningitis and bloodstream infections. About 1,600 healthy children and teens aged 2 to 17 in China will receive either the new vaccine or a currently approved one. Rese…

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu (H5N1). About 720 healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to see if the vaccine is safe and triggers a strong…

This early-stage study tests a new drug called KK4277 in healthy volunteers and people with lupus (SLE or CLE). The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body. The study does not aim to cure lupus, bu…

This early-stage study tests whether black raspberry confections can help prevent oral cancer in 67 healthy volunteers. Researchers will measure how the body absorbs berry compounds and how they affect genes linked to cancer and inflammation. Participants follow a berry-restricte…

This study at Stanford University compares ketamine to a placebo (saline) during sedation in 15 healthy volunteers. The goal is to see how different sedation methods affect dreams and brain activity, not to treat depression. Participants will have four sessions with brain monitor…

This study is for 50 healthy volunteers aged 18 to 80. It uses a special substance called [13C]pyruvate during an MRI scan to see how different organs use energy. The goal is to gather normal reference data and improve image quality, not to treat any disease. Participants will re…

This study tests a new drug called IBI3027 to see if it behaves the same as an approved drug, Dupilumab, in healthy Chinese men aged 18-45. Participants receive a single injection and are monitored for 56 days. The goal is to compare drug levels and safety, not to treat any disea…

This early-stage study is testing a new drug called SL-325 in 72 healthy volunteers to see if it is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. This study does …

This study aimed to measure DNA damage in mouth cells from daily smokers, daily vapers, and people who never use tobacco or nicotine. Researchers wanted to see which types of damage last longer and might lead to oral cancer. The study was withdrawn before any participants were en…

This study uses a new type of eye scanner (OCT) in 20 healthy adults to improve how doctors detect eye diseases. Participants have no eye problems and will help test the device's speed and image quality. The goal is to make the technology better before using it in patients.

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain activity and body responses in healthy people. Twelve volunteers with past psychedelic experience will take four doses of psilocybin and undergo MRI and EEG scans. The goal is to better un…

This early-stage study looks at whether sirolimus, an FDA-approved drug, can improve blood flow to the brain in healthy adults with and without a genetic risk for Alzheimer's disease. Researchers will use MRI scans to measure changes in brain blood flow and also explore how the l…

This study collects blood, DNA, and lung tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. Researchers aim to uncover the biological causes of this lung-scarring disease. No treatments or interventions are tested; the goal is purely …

This study looks at how a brain stimulation technique called TMS affects decision-making in people with opioid use disorder and healthy volunteers. Participants will have brain scans and play computer games while receiving real or placebo TMS. The goal is to understand brain acti…

This study looks at how natural bacteria in the gut can change the way the cholesterol-lowering drug rosuvastatin works. About 100 healthy adults will take the medication for 16 weeks, and researchers will measure changes in gut bacteria and cholesterol levels. The goal is to und…

This early-stage study tests the safety of a new drug called ORKA-002 in 24 healthy adults. Participants receive a single dose and are monitored for side effects and how the drug moves through the body. The goal is to gather initial safety data before testing in patients with a s…

This study was designed to test a new breath-activated inhaler (EDDIS) in healthy adults aged 18 to 45. Participants would have inhaled a single dose of a harmless radioactive tracer to see where the mist lands in the lungs and how the body absorbs it. The study was withdrawn bef…

This study is creating a large registry and biorepository of health information and samples from 50,000 adults in Cabarrus County and Kannapolis. The goal is to provide a resource for future research on chronic diseases and other health conditions. Participants will provide data …

This study checks if a new single pill containing three diabetes drugs (gemigliptin, dapagliflozin, metformin) works the same as taking two separate pills. It involves 58 healthy adults aged 19-50 who receive one dose of each treatment under fasting conditions. The goal is to com…

This early-stage study tests a new drug called ABBV-277 in 32 healthy adults for the first time. The main goal is to check its safety and how the body processes it. Participants receive a single dose and are monitored closely. This study does not aim to treat any disease.

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and TMS. The goal is to understand how p…

This early-stage study tests a new drug called JADE101 in 32 healthy adults aged 18-55. The main goal is to check if it is safe and how the body handles it. Participants receive either a single dose of JADE101 or a placebo. This study does not aim to treat any disease.

This study was designed to see how different drugs and drug combinations change mood, pain tolerance, and thinking skills in healthy adults aged 18 to 55. Researchers planned to measure how much of a drug people would take and how much they would pay for it. The study was withdra…

This early-stage study is testing a new drug, budoprutug, in 38 healthy adults aged 18 to 60. The main goal is to see if the drug is safe and how the body processes it when given as a shot or through an IV. Since participants are healthy, this study is not meant to treat any dise…

This study looks at the genes of about 1,600 people aged 45 to 65 to learn how gene changes relate to heart disease and other health conditions. Participants give blood samples and have heart tests, but the study does not test any treatment. The goal is to improve our understandi…