HEALTHY VOLUNTEERS

This early-stage study tested a new meningococcal B vaccine in 576 healthy people, from infants to adults. Researchers checked for side effects and measured immune responses, comparing the new vaccine to two already-approved ones. The goal was to see if the vaccine is safe and tr…

This early-stage study tested a new oral drug, ASP5502, for primary Sjögren's syndrome, an autoimmune condition causing dry eyes and mouth. It involved 116 healthy adults and patients to check safety and how the body processes the drug. The study was terminated, but results may g…

This early-stage study tested an experimental drug called PF-07258669 in older adults (ages 60-89) who are at risk of malnutrition. The goal was to see if the drug is safe and how it affects the body. Participants took the drug or a placebo for 16 weeks. The study was terminated …

This early-phase study tested a new radioactive imaging drug called 11C-MC1 to see if it can help detect inflammation in people with rheumatoid arthritis or idiopathic inflammatory myopathy, as well as in healthy volunteers. Participants received PET/CT scans after an injection o…

This study tested a radiofrequency-based treatment on the skin of healthy volunteers and people with hidradenitis suppurativa (a painful skin condition). The main goal was to see if the treatment is safe and tolerable. The study was stopped early, but it aimed to understand how t…

This study tested three portable inhaler devices in 10 healthy adults to see how accurately they measure airflow and record breaths. No medication was used—only a harmless salt solution. The goal was to compare device performance and user comfort, not to treat any disease.

This study tested whether a device that emits UV-C light can safely sanitize hands instead of using chemical sanitizers. Twenty-three healthy volunteers with light skin were exposed to UV-C or UV-B light, and small skin samples were taken to check for DNA damage. The study was te…

This study looked at how healthy adults respond to breathing air with less oxygen for up to 7 days. Researchers measured oxygen levels in the blood, red blood cell production, and lung pressure to understand the body's adjustments. The goal was to define safety and basic response…

This early-stage study tested the safety and tolerability of a new drug called AMG 378 in 48 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The study was termina…

This study tested whether a single session of non-invasive brain stimulation (alpha-tACS) could change brain activity and help people break habits. Researchers compared the stimulation to a fake (sham) version in healthy adults and those with a history of heavy drinking. The stud…

This study aimed to find substances in blood and urine that could signal kidney damage earlier than current tests. Researchers compared samples from healthy volunteers, people with low fluid levels, those at high risk for kidney failure, and patients with acute kidney failure. Th…

This study looked at whether a mindfulness training program could change brain connections in teenagers who vape tobacco. Researchers used brain scans to see if these changes were linked to less vaping. The study was small and ended early, so results are limited.

This study surveyed teens aged 13–18 and their parents to learn about vaping habits, attitudes, and mental health. Participants answered anonymous questions online about vaping, drug use, mood, and social influences. The goal was to better understand why teens vape and how parent…

This early-phase study tested the safety and tolerability of an experimental drug called iCP-NI in 24 healthy adults. Participants received either the drug or a placebo by intravenous infusion. The trial was terminated, so no conclusions about effectiveness can be drawn.

This study tested two special gases (hyperpolarized xenon and perfluoropropane) that people inhale to make their lungs show up better on an MRI. The goal was to develop better imaging methods and hardware to get clearer pictures of lung function. The study involved 24 healthy vol…

This early-stage study tested two liquid versions of the drug maribavir (used to treat certain viral infections) to see how well they are absorbed, how they taste, and if they are safe compared to the current tablet. The study involved 20 healthy adults, not children, to gather i…