Pfizer tests experimental pill to help older adults regain lost appetite
NCT ID NCT07086664
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tested an experimental drug called PF-07258669 in older adults (ages 60-89) who are at risk of malnutrition. The goal was to see if the drug is safe and how it affects the body. Participants took the drug or a placebo for 16 weeks. The study was terminated early, and only 7 people enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PF-07258669 (oral tablet)
What this could lead to
If it works, this could point toward a treatment for unintended weight loss in older adults, helping improve appetite and nutrition.
What could go wrong
This is a very early, small Phase 1 trial in healthy volunteers, not patients. The study was terminated, so results may not be available. Safety and effectiveness are not yet known.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AA Medical Research Center
Flint, Michigan, 48504, United States
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Accel Research Sites - Birmingham Clinical Research Unit
Birmingham, Alabama, 35216, United States
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Alpha Recherche Clinique
Québec, Quebec, G3K 2P8, Canada
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Bradenton Research Center, Inc.
Bradenton, Florida, 34205, United States
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Centre de Recherche Saint-Louis inc.
Québec, G1W 4R4, Canada
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Circuit Clinical
Secaucus, New Jersey, 07094, United States
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Circuit Clinical /North Hudson Community Action Corporation
West New York, New Jersey, 07093, United States
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Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
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De La Cruz Research Center, LLC
Miami, Florida, 33184, United States
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Diex Recherche Inc. Division Victoriaville
Victoriaville, Quebec, G6P 3Z8, Canada
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Headlands Research Orlando
Orlando, Florida, 32819, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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Javara - Nevada Health Centers - Carson City
Carson City, Nevada, 89706, United States
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Yao Tokushukai General Hospital
Yao Shi, Osaka, 581-0011, Japan