Pfizer tests experimental pill to help older adults regain lost appetite

NCT ID NCT07086664

Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested an experimental drug called PF-07258669 in older adults (ages 60-89) who are at risk of malnutrition. The goal was to see if the drug is safe and how it affects the body. Participants took the drug or a placebo for 16 weeks. The study was terminated early, and only 7 people enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-07258669 (oral tablet)
What this could lead to: If it works, this could point toward a treatment for unintended weight loss in older adults, helping improve appetite and nutrition.
What could go wrong: This is a very early, small Phase 1 trial in healthy volunteers, not patients. The study was terminated, so results may not be available. Safety and effectiveness are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Locations

AA Medical Research Center

Flint, Michigan, 48504, United States
Accel Research Sites - Birmingham Clinical Research Unit

Birmingham, Alabama, 35216, United States
Alpha Recherche Clinique

Québec, Quebec, G3K 2P8, Canada
Bradenton Research Center, Inc.

Bradenton, Florida, 34205, United States
Centre de Recherche Saint-Louis inc.

Québec, G1W 4R4, Canada
Circuit Clinical

Secaucus, New Jersey, 07094, United States
Circuit Clinical /North Hudson Community Action Corporation

West New York, New Jersey, 07093, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
De La Cruz Research Center, LLC

Miami, Florida, 33184, United States
Diex Recherche Inc. Division Victoriaville

Victoriaville, Quebec, G6P 3Z8, Canada
Headlands Research Orlando

Orlando, Florida, 32819, United States
JEM Research Institute

Atlantis, Florida, 33462, United States
Javara - Nevada Health Centers - Carson City

Carson City, Nevada, 89706, United States
Yao Tokushukai General Hospital

Yao Shi, Osaka, 581-0011, Japan

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