New PET tracer aims to light up inflammation in joint and muscle diseases
NCT ID NCT03912428
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This early-phase study tested a new radioactive imaging drug called 11C-MC1 to see if it can help detect inflammation in people with rheumatoid arthritis or idiopathic inflammatory myopathy, as well as in healthy volunteers. Participants received PET/CT scans after an injection of the drug, and some also took celecoxib to see if it blocked the signal. The study was terminated early, so its findings are limited, but the goal was to develop a better way to visualize inflammation in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
11C-MC1 (a radioactive imaging drug)
What this could lead to
If it works, this could lead to a better way to see inflammation in the body using PET scans, helping doctors diagnose and monitor conditions like arthritis and myositis.
What could go wrong
This was a very early (Phase 1) study that has already been terminated, so results are limited. The imaging drug is experimental and may not prove useful for routine diagnosis.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States