HEALTHY VOLUNTEERS

This study will monitor the safety of the MenQuadfi vaccine in 706 people aged 6 weeks to 55 years in South Korea. Researchers will track side effects like injection-site reactions and serious adverse events as the vaccine is used in real-world clinics. The goal is to confirm the…

This study is checking the safety of a high-dose flu vaccine called Efluelda in adults aged 65 and older in South Korea. About 670 participants will receive one shot and be monitored for side effects for about a month. The goal is to see how often reactions like injection site pa…

This first-in-human study will test a new radioactive imaging agent called MeFAMP to see if it can safely and accurately detect brain tumors using PET scans. The study includes 28 people: healthy volunteers and patients with recurrent high-grade glioma or brain metastases from ot…

This study tests whether the drug Qsymia, combined with lifestyle coaching, can prevent obesity in 140 adolescents and young adults (ages 18-25) who are overweight (BMI 25-30) and have a family history of obesity. Participants will receive either Qsymia or a placebo, plus coachin…

This Phase 2 trial tests whether a single dose of (2R,6R)-hydroxynorketamine (HNK), a non-addictive ketamine metabolite, can reduce acute pain in 92 healthy adults. Participants receive either HNK or a placebo intravenously and undergo pain tests, brain scans, and safety monitori…

This early-stage study will test whether a liquid form of metformin causes fewer stomach problems than the standard tablet. Twenty-four healthy adults will each try both the liquid and tablet versions in a random order. The goal is to see which is better tolerated, which could ev…

This phase 1 trial tests the drug IPG1094 in 24 healthy Chinese adults to understand how the body absorbs, processes, and eliminates it. Part A examines whether food affects a single dose, while Part B looks at repeated dosing over 10 days. All participants are monitored for safe…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

This study checks whether Kinovea, a free video analysis software, can consistently measure knee and hip angles when people stand up from a chair. Healthy volunteers aged 18 to 45 will be recorded doing sit-to-stand movements, and three physiotherapists will analyze the videos se…

This early-stage trial tests the safety and how the body handles TEV-56286 (also known as emrusolmin or anle138b) in healthy adults. Participants receive either single or multiple rising doses of the drug or a placebo. The study measures how the drug is absorbed, distributed, and…

This Phase IV trial will compare how well a new vitamin B12 supplement (Ampli-B) is absorbed versus standard vitamin B12 in 12 healthy adults aged 50 and older. Each person will take a single dose of both supplements in random order, with a 10-day break in between. The study meas…

This study explores how focused ultrasound can change brain activity in healthy adults. Researchers will send sound waves through the skull to the visual and hearing parts of the brain to see what people perceive. The goal is to find the best settings for future treatments of con…

This study checks whether a generic diosmin tablet (Dimotec) releases the same amount of active ingredient into the blood as the brand-name Detralex after a meal. Healthy adults aged 18 to 55 take a single dose of each tablet in random order, and blood samples are compared. The g…

This early-stage trial is the first to test AB102 in humans. It will give the drug to 130 healthy volunteers to check its safety and how the body processes it. The study is not designed to treat any disease, but to gather essential information for future research.

This early-stage study tests the safety of a new drug, TESP-0401, in 68 healthy volunteers. Participants receive either the drug or a placebo as a single dose or daily for 7 days. Researchers will monitor side effects and measure how the body processes the drug.

This early-stage trial is testing a new drug called ZL-1503 in healthy volunteers. The goal is to understand how the drug moves through the body, how safe it is, and how well people tolerate it after a single injection under the skin or into a vein. The study involves 36 healthy …

This early study tests a new drug called BMS-986521 in 12 healthy adults. Researchers use PET scans to see how much of the drug reaches and attaches to M4 receptors in the brain. The goal is to learn about the drug's action, not to treat any illness. This is a first step before t…

This study will test whether a small injection of lidocaine around the radial artery in the wrist can temporarily reduce sympathetic nerve activity in 20 healthy volunteers. Researchers will measure blood flow and hand temperature before and after the injection, using cold water …

This study looks at how two types of fasting—Ramadan dry fasting (no food or water from dawn to sunset) and 16:8 time-restricted feeding (water allowed)—affect the cleanup and renewal of mitochondria, the energy factories in your cells. Researchers will track blood markers in 120…

This early-stage trial will test a new tablet form of sonrotoclax that can be mixed with water and swallowed. Researchers want to see if the body absorbs it the same way as the current tablet, and whether taking it with food changes absorption. Twelve healthy adults will each rec…

This early-stage study tests a new drug called BMS-986533 in 118 healthy adults to see if it's safe and how the body processes it. Researchers will also check if food or stomach acid changes how the drug works, and if it interacts with other medications. Participants will not rec…

This study looks at how brief periods of low oxygen (intermittent hypoxia) affect a measure called 'loop gain,' which reflects how your body controls breathing. Researchers want to understand if these oxygen dips can make breathing control less stable, which may help explain slee…

This study looks at whether an 8-week dairy drink with extra protein, calcium, and vitamin D can help physically active adults aged 18-39. About 50 volunteers will drink the product and take tests on strength, body composition, and how they feel. The goal is to see if the drink i…

This study tests whether a supplement called TRPTI (oleoylethanolamide) can improve gut health and metabolism in healthy adults. Researchers will measure changes in blood markers and gut bacteria over 8 weeks. 90 healthy adults aged 18+ with a BMI between 18.5 and 29.9 will take …

This study tests a new set of free audio exercises designed to make mindfulness research more inclusive. The exercises are written at a 5th-6th grade reading level and don't require a teacher or quiet space. 360 healthy adults will listen to one 12-minute audio and answer questio…

This early-stage study looks at how a high-fat meal or a standard meal changes the way the body absorbs a single dose of the drug VV913. Twelve healthy Chinese men will take the drug under different meal conditions to measure side effects and drug levels in the blood. The results…

This early-stage study looks at how food and ethnic background affect the way a new drug, JPI-547, moves through the body. It involves 36 healthy men of Korean, Caucasian, or Chinese descent who take a single dose. The goal is to gather safety and drug-level data, not to treat an…

This study looks at how long heart rate recordings should be to best detect changes from a mild nerve stimulation in the ear. Forty healthy adults will receive both real and fake stimulation in random order. Researchers will compare 1-minute, 5-minute, and 10-minute recordings to…

This study will test how stimulating the ear with mild electrical pulses at different frequencies affects heart rate, breathing, and blood pressure in 36 healthy adults. Each person will try five different stimulation settings (including a fake one) in separate sessions. The goal…

This study will test whether stimulating the vagus nerve through the ear for 5, 10, or 15 minutes changes heart rate, blood pressure, and other body signals in healthy adults. Forty-four participants will receive either real or sham stimulation in random order. The goal is to see…

This study tests whether real-time fMRI can alter how healthy people perceive social interactions. Ten participants will undergo multiple MRI sessions where their brain activity is monitored and used to trigger specific trials. The goal is to see if this feedback can shift their …

This study looks at whether Kinesio Taping can immediately improve hand and arm function in healthy adults. Thirty-six participants will be randomly assigned to receive real Kinesio Tape, sham tape (no tension), or no tape at all. They will perform tests like grip strength, typin…

This study explores whether different vibration frequencies from a smartphone can temporarily improve hand grip strength, touch sensitivity, and reaction time in healthy young adults. Twenty participants will hold an iPhone running a custom app that delivers vibrations at 80, 150…

This early-stage trial will test the safety and how the body handles a new drug called VV913. It involves 24 healthy Chinese men aged 18 to 45. Participants will receive either a low, medium, or high dose of VV913 or a placebo, and researchers will monitor side effects and drug l…

This early-stage study tests whether a new formulation of the antibiotic polymyxin B (VRP-034) is safer for the kidneys than the current version. It involves 48 healthy adult men who will receive one or more doses of either the new or standard drug. Researchers will measure kidne…

This early-stage study tests the safety of a new drug called HS-20152 in 32 healthy adults aged 18 to 64. The drug targets the complement system, part of the body's immune response. Researchers will monitor for side effects and measure how the drug moves through the body. This st…

This study looks at how the design of breathing masks affects breathing in 10 healthy volunteers. Participants will try four different masks while using a breathing machine. The goal is to see if mask design changes breathing patterns, carbon dioxide levels, and breathing rate. T…

This study looks at how different phases of the menstrual cycle relate to muscle strength and physical performance in healthy, active women aged 18 to 35. Participants will track their cycle with a phone app and attend three lab visits for strength tests and body measurements. Th…

This early-stage study tests the safety and tolerability of a new oral drug called ISM4808 in 86 healthy adults aged 18-55 in China. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to…

This early-stage study tests the safety and tolerability of a new drug called migaldendranib in 36 healthy volunteers. Participants receive weekly injections, and researchers monitor for side effects and how the drug moves through the body. The study does not aim to treat any dis…

This study tests a new computer method (HDC) to recognize hand gestures using muscle sensors on the forearm. Ten healthy volunteers will perform gestures while wearing a sensor armband. The goal is to see if the new method is more accurate than standard approaches. This is a tech…

This early-phase trial will test the safety and tolerability of KMY tablets in 120 healthy adults aged 18 to 45. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves through the body. The study also looks at …

This study compares two drugs, IN-M00007 and IN-R00007, to see if they are equivalent in healthy adults aged 19 to 59. Sixty volunteers will take a single dose of each drug in random order, and researchers will measure how the drugs are absorbed and how safe they are. The goal is…

This early-stage trial will give 24 healthy adults a single dose of Hezkue oral sildenafil suspension after they drink a moderate amount of alcohol. Researchers will measure how the drug moves through the body and how quickly it starts working. The goal is to understand any effec…

This early-stage study will test how two different liquid forms of metformin affect blood sugar compared to regular metformin tablets. Twenty-four healthy adults will take short-term doses and have their blood glucose measured. The goal is to see if the liquid versions work diffe…

This study tests whether a single dose of nicotinamide riboside (NR), a form of vitamin B3, can improve sleep in healthy adults who have mild sleep troubles. Twenty participants will have their sleep measured overnight using advanced monitoring, after taking either NR or a placeb…

This study tests how stimulating the vagus nerve at different frequencies affects heart rate, blood pressure, and breathing in 36 healthy adults. Participants will receive five different stimulation frequencies (including a sham) in random order. The goal is to find which frequen…

This study will compare 69 healthy volunteers to people with idiopathic environmental intolerance (IEI), a condition where patients experience symptoms like pain, fatigue, or dizziness from everyday exposures (e.g., chemicals, Wi-Fi) with no clear medical cause. Researchers will …

This study will test a new markerless motion capture system that uses only four cameras to analyze how children walk. Researchers will enroll 125 healthy children aged 6 to 17. The goal is to see if this simpler setup can provide useful information about walking patterns, which c…

This study tests whether doing sit-to-stand exercises with a blood flow restriction cuff on the thigh can improve back muscle endurance and balance more than the same exercises without the cuff. Seventy healthy young adults aged 20-25 will exercise twice a week for six weeks. Res…