Wrist injection may tame overactive nerves, early study hints
NCT ID NCT07429292
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether a small injection of lidocaine around the radial artery in the wrist can temporarily reduce sympathetic nerve activity in 20 healthy volunteers. Researchers will measure blood flow and hand temperature before and after the injection, using cold water to trigger a stress response. The goal is to see if this simple block can dampen the body's 'fight or flight' signals in the hand.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lidocaine
- What this could lead to
- If successful, this could provide a new way to study and potentially treat conditions involving overactive sympathetic nerves, like Raynaud's phenomenon.
- What could go wrong
- This is a very small, early-phase study in healthy people, not patients. The effect may be temporary or not translate to real-world treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Duke University Medical Center
Durham, North Carolina, 27710, United States
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