Wrist injection may tame overactive nerves, early study hints
NCT ID NCT07429292
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether a small injection of lidocaine around the radial artery in the wrist can temporarily reduce sympathetic nerve activity in 20 healthy volunteers. Researchers will measure blood flow and hand temperature before and after the injection, using cold water to trigger a stress response. The goal is to see if this simple block can dampen the body's 'fight or flight' signals in the hand.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lidocaine
What this could lead to
If successful, this could provide a new way to study and potentially treat conditions involving overactive sympathetic nerves, like Raynaud's phenomenon.
What could go wrong
This is a very small, early-phase study in healthy people, not patients. The effect may be temporary or not translate to real-world treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States