New shot could cool menopause hot flashes

NCT ID NCT07118891

Ongoing Symptom relief Sponsor: AbCellera Biologics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a new biologic drug called ABCL635 for moderate-to-severe hot flashes in postmenopausal women. The study first checks safety in healthy volunteers, then measures how well the drug reduces hot flash frequency and severity. About 136 people will take part, receiving either the drug or a placebo by injection under the skin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABCL635 (a biologic drug given by injection under the skin)
What this could lead to: If it works, this could lead to a new treatment option that reduces the frequency and severity of hot flashes in menopausal women.
What could go wrong: This is a very early first-in-human trial with only 136 participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to improve symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE

Contacts and locations

Locations

Alpha Recherche Clinique

Lévis, Quebec, G6V 0C9, Canada
Altasciences Company Inc.

Mount Royal, Quebec, H3P 3P1, Canada
CaRe Clinics

Calgary, Alberta, T2N 4L7, Canada
CaRe Clinics

Red Deer, Alberta, T4P 1K4, Canada
Centricity Research

Toronto, Ontario, M4G 3E8, Canada
Centricity Research

Toronto, Ontario, M4W 4L6, Canada
Clinique RSF Inc.

Québec, Quebec, G1V 3M8, Canada
Diex Recherche Québec

Québec, Quebec, G1V 4T3, Canada
Diex Recherche Sherbrooke

Sherbrooke, Quebec, J1L 0H8, Canada
Diex Recherche Trois-Rivières

Trois-Rivières, Quebec, GSA 4P3, Canada
Diex Recherche Victoriaville

Victoriaville, Quebec, G6P 3Z8, Canada
GCP Research

Montreal, Quebec, H1Y 3H5, Canada
Mount Saint Joseph Hospital Clinical Trials Phase 1 Unit

Vancouver, British Columbia, V5T 3N4, Canada

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