Heart check for sickle cell drug: early safety trial begins
NCT ID NCT07023029
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 1 trial studied how etavopivat, a potential new medicine for sickle cell disease and thalassemia, affects the heart's electrical activity. Thirty-three healthy adults received single doses of etavopivat, a placebo, or an approved heart medication (moxifloxacin) to compare effects. The goal was to check for any heart rhythm changes before testing the drug in patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Etavopivat
- What this could lead to
- If successful, this study will confirm that etavopivat is safe for the heart, supporting its further development as a treatment for sickle cell disease and thalassemia.
- What could go wrong
- This is an early, small study in healthy volunteers, not patients. It only looks at heart effects, not whether the drug works for the disease. Unexpected heart risks could still emerge in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
PAREXEL Intl - EPCU-Baltimore
Baltimore, Maryland, 21225, United States
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