E-Cigarettes vs regular cigarettes: which delivers more nicotine?

NCT ID NCT05457634

Completed Knowledge-focused Sponsor: Fontem US LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how much nicotine gets into the blood and how strong the urge to smoke is when using blu disposable e-cigarettes compared to regular cigarettes. Twenty adult smokers who smoke at least 10 cigarettes a day took part. They used both their usual cigarette and different flavored blu e-cigarettes in controlled sessions to measure nicotine levels and smoking behavior.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine (from e-cigarettes and combustible cigarettes)
What this could lead to: If successful, this study could help regulators understand how e-cigarettes compare to regular cigarettes in terms of nicotine delivery and addiction potential.
What could go wrong: This is a small, completed study with only 20 healthy smokers, so results may not apply to all smokers or long-term use. It does not test health effects or quitting success.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Locations

LA Clinical Trials, LLC

Burbank, California, 91505, United States

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