Malaria drug tafenoquine put to the test: is it safe for Long-Term use?

NCT ID NCT03320174

Completed Knowledge-focused Sponsor: 60 Degrees Pharmaceuticals LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at the long-term safety of tafenoquine, a drug used to prevent malaria. 600 healthy volunteers took either tafenoquine or a placebo daily for three days, then weekly for 51 weeks. Researchers monitored eye health and other side effects to see if the drug is safe for extended use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tafenoquine
What this could lead to: If successful, this could confirm that long-term use of tafenoquine is safe, supporting its use for preventing malaria.
What could go wrong: This is an early-phase safety study in healthy people, not patients. It cannot prove the drug works for any disease, and unexpected side effects may still emerge in larger or longer studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Locations

Linear Clinical Research

Nedlands, Western Australia, 6009, Australia
Retina Consultants of Southern Colorado

Colorado Springs, Colorado, 80909, United States
Valley Retina Institute

McAllen, Texas, 78503, United States

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