Scientists probe Drug-Induced sunburn reactions
NCT ID NCT00353158
First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 8 times
Summary
This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients taking voriconazole. By comparing reactions to controlled light exposure, they hope to uncover the biological pathways involved. The goal is to better understand phototoxicity, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Doxycycline and Voriconazole
- What this could lead to
- If successful, this could help identify who is at risk for severe sunburn-like reactions from medications, leading to better prevention strategies.
- What could go wrong
- This is a small, early-phase pilot study focused on understanding mechanisms, not testing a treatment. Results may not apply to broader populations or lead to immediate clinical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BACTERIAL INFECTIONS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a new oral drug pass its first safety hurdle?
- Can a new drug play nice with common medicines? a trial investigates
- Could a new pill quiet chronic pain? early trial puts it to the test
- Brain waves under pressure: can light uncover the signature of mental work?
- Can acting as patients teach nurses to truly listen?
- Could a simple blood test curb antibiotic overuse in sick kids?