Scientists probe Drug-Induced sunburn reactions
NCT ID NCT00353158
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients taking voriconazole. By comparing reactions to controlled light exposure, they hope to uncover the biological pathways involved. The goal is to better understand phototoxicity, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Doxycycline and Voriconazole
What this could lead to
If successful, this could help identify who is at risk for severe sunburn-like reactions from medications, leading to better prevention strategies.
What could go wrong
This is a small, early-phase pilot study focused on understanding mechanisms, not testing a treatment. Results may not apply to broader populations or lead to immediate clinical changes.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States