BACTERIAL INFECTIONS

This study tests a new vaccine to protect babies against pneumococcal infections, which can cause pneumonia and meningitis. About 600 healthy infants in Thailand will receive either the new or a standard vaccine at 2, 4, and 12-15 months old. Researchers will check how well the v…

This study tests whether a medicine called XEMBIFY, given every two weeks alongside standard care, can reduce serious bacterial infections in adults with certain blood cancers (chronic lymphocytic leukemia, multiple myeloma, or non-Hodgkin lymphoma) who also have low antibody lev…

This early-phase trial tests the safety and tolerability of a new antibiotic called JKN2501 in 66 healthy adults in China. Participants receive either the drug or a placebo by IV infusion, and researchers monitor for side effects and how the drug moves through the body. The goal …

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study is creating a registry of 600 children under 18 with meningitis treated at hospitals across Brazil. Researchers will collect data during and after hospitalization to see how well current treatments work and what long-term problems, like hearing loss, occur. The goal is…

This study looks at how people recover after infective endocarditis, a serious heart infection. Researchers want to see if a 12-week exercise program can improve physical fitness, fatigue, and quality of life. About 50 adults who had the infection will take surveys, do interviews…

This early-stage study is testing a single dose of an experimental antibiotic combination (cefiderocol/xeruborbactam) given through a vein. The goal is to see how safe it is and how the body processes it in 40 adults with different levels of kidney function, including those on di…