HEALTHY VOLUNTEERS

This study tests a new vaccine (PCV21) in healthy infants to see if it safely helps their bodies build defenses against 21 types of pneumococcal bacteria, which can cause serious illnesses like pneumonia and meningitis. About 2,195 babies will receive either the new vaccine or a …

This early-stage study tests a new medicine called NNC0581-0001 in 48 adults with fatty liver and possible liver inflammation. Participants receive either the drug or a placebo as a monthly injection for 3 months. The main goal is to check safety and how the body processes the dr…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This early-phase study tests whether the experimental drug TAK-781 is safe and tolerable. First, healthy volunteers receive either the drug or a placebo. Then, people with primary sclerosing cholangitis (PSC) receive the drug to see how their bodies handle it. The study does not …

This study tests a new, ultra-low dose PET scan that uses 10 to 100 times less radiation than current methods to detect Alzheimer's disease and other dementias. Researchers will give 200 adults (including healthy volunteers) a radioactive tracer and use a high-sensitivity scanner…

This study tests whether a 12-week program combining modern dance with mindfulness exercises can improve psychological well-being, reduce stress, and increase happiness in recreational adult dancers. About 160 adults who already take dance classes will be randomly assigned to eit…

This early-stage study tests a single inhaled dose of RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD), a condition that causes lung scarring. The goal is to measure how the drug moves through the body and check for safety, not to treat the diseas…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive one dose and are closely monitored for side effects. The study does not aim to treat any disease, but to gather safety data for futu…

This early-stage study tests a single oral dose of VV261 tablets in 58 healthy Chinese adults aged 18 to 45. The goal is to check safety, side effects, and how the drug moves through the body. Participants are randomly assigned to receive either the drug or a placebo, and no trea…

This study aims to improve how MRI scans are done by testing new and better scanning methods. It involves 1,000 healthy volunteers and current NIH participants aged 18 and older. Participants will have one or more MRI scans, sometimes with a contrast dye, and blood samples may be…

This early-stage study is testing the safety and how the body handles three experimental drugs (DWJ1622, DWC202313, DWC202314) in 40 healthy adults. Participants take the drugs under fasting conditions and are monitored closely. The goal is to gather basic safety and drug-level i…

This early-stage study is testing a new drug, SEP-479, in 150 healthy adults aged 21 to 60. The main goal is to see if the drug is safe and how the body processes it. Participants will take single or multiple doses, and researchers will monitor side effects and drug levels in the…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep tests, and blood work to compare four groups: people who recently had suicidal thoughts or attempts, those with past thoughts, people wit…

This early-stage study tests a new substance called RAD301 in 9 people—some healthy, some with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how RAD301 moves through the body and how much radiation reaches organs and tumors, and to che…

This early-stage study checks how two experimental drugs (DWJ1622 and a combination of DWC202313 and DWC202314) behave in the body when taken together after a meal. It involves 36 healthy adults and focuses on safety and drug levels in the blood. There is no treatment or cure inv…

This study looks at whether a gentle chest massage technique, called intercostal mobilization, can help healthy but inactive adults aged 18-30 breathe better and walk farther. Researchers will measure lung function and walking performance in 90 volunteers before and after the mas…

This study looks at how healthy men absorb, break down, and eliminate an experimental drug called E2086. Ten participants will receive a single dose with a radioactive tracer to track the drug's path. The goal is to understand the drug's metabolism and excretion, not to treat any…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans to test these connections in 204 healthy adults aged 18 to 40. The goal is to bet…

This study looks at whether the artificial sweetener sucralose changes how the body absorbs and processes certain medicines. Overweight Hispanic and Black women aged 18-60 will take sucralose or a placebo for four weeks while researchers measure drug levels, hormones, and gut bac…

This study tests a new non-invasive method called temporal interference (TI) to stimulate deep brain regions using harmless electrical currents. Researchers will scan the brains of 30 healthy adults aged 18-50 to see if TI can safely activate deep areas without affecting the oute…