HEALTHY VOLUNTEERS

This study tests a new vaccine (MenACYW) to protect against four types of meningococcal bacteria that can cause serious infections like meningitis. About 1,600 healthy children and teens aged 2 to 17 in China will receive either the new vaccine or a currently approved one. Resear…

This study tests a new 21-valent pneumococcal conjugate vaccine (PCV21) in about 1,092 healthy infants and toddlers. The goal is to see if PCV21 is safe and helps the body produce antibodies against pneumococcal bacteria better than the current licensed vaccine. Participants rece…

This early-stage trial tests a new booster vaccine, CD40.Pan.CoV, designed to protect against several types of coronaviruses. About 48 healthy adults in France will receive either a low or high dose, with or without an adjuvant (a substance that boosts immune response). The main …

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu (H5N1). Healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to check safety and see how well the vaccine triggers an immu…

This early-stage study tests a new vaccine (VXB-241) designed to protect against two viruses that cause serious lung infections in older adults: RSV and HMPV. About 144 healthy adults aged 60-83 (and some younger adults) will receive one dose of the vaccine at different strengths…

This study tests a new vaccine that protects against five types of meningococcal bacteria (A, B, C, W, Y) in healthy children aged 2 months to 9 years. Researchers want to see if it is safe and triggers a strong immune response compared to existing vaccines. The vaccine is given …

This early-stage study tests a new medicine called CMP-CPS-001 in healthy adults and people with a genetic condition called OTC deficiency, which makes it hard for the body to break down ammonia. The goal is to check if the drug is safe and how it works in the body. About 120 par…

This early-stage study is testing a new drug called KK4277 to see if it is safe for people with lupus. The trial first gives a single dose to healthy men, then repeated doses to people with systemic or cutaneous lupus. The main goal is to check for side effects and measure how th…

This study tests an experimental drug called MRT-8102 for the first time in humans. It includes healthy volunteers and people with heart risk factors and high levels of CRP, a marker of inflammation. The goal is to check if the drug is safe and to find the right dose for future t…

This early-stage study is testing a new drug called ABCL575 for the first time in people. About 40 healthy adults will receive either a single dose of the drug or a placebo to see if it is safe and how the body processes it. The main goal is to check for side effects and changes …

This study enrolls 20 healthy adults to test a new version of an eye imaging device called optical coherence tomography (OCT). The goal is to improve image quality and speed so that eye diseases can be detected earlier. Participants have no eye problems and will not receive any t…

This study involves 50 healthy volunteers aged 18-80 to learn how a substance called [13C]pyruvate moves through the body during an MRI scan. The goal is to improve image quality by seeing how healthy organs use this substance for energy. Researchers will also test different inje…

This study collects blood, DNA, and lung tissue samples from 315 people with pulmonary fibrosis, their family members, and healthy volunteers. Researchers will analyze these samples to learn more about what causes the disease. The goal is to better understand the disease mechanis…

This early-stage study tests a single dose of a new drug called ABBV-277 in 32 healthy adults. The main goal is to check if it is safe, how the body processes it, and whether it triggers an immune response. Participants must be in good general health and have a body mass index be…

This early-stage study tests the safety of a new drug called VSA012 in 40 healthy adults. The drug targets the complement system, which is part of the immune system, and may help treat diseases like PNH where this system is overactive. Participants receive a single dose of VSA012…

This study looks at how a non-invasive brain stimulation technique called TMS affects decision-making in people with opioid use disorder and healthy volunteers. Participants will have MRI scans and play computer games while receiving real or placebo TMS. The goal is to understand…

This study was designed to test a new breath-activated inhaler (EDDIS) in healthy adults aged 18-45. Participants would have inhaled a tiny amount of a radioactive tracer so researchers could see where the drug lands in the lungs and check for side effects. The study was withdraw…

This study aims to understand the distinct mental states and physical reactions that occur during a psychedelic experience. Up to 12 healthy volunteers with prior psychedelic use will receive four doses of psilocybin (one low and three high) while undergoing MRI and EEG scans. Re…

This study looks at the genes of healthy adults aged 45 to 65 to learn how gene changes relate to heart disease. Participants provide blood samples and undergo noninvasive heart tests. Researchers sequence about 400 heart-related genes and share any important findings. The goal i…

This study looks at how a new pill that combines three diabetes medicines (gemigliptin, dapagliflozin, and metformin) works in healthy adults. About 58 people will take either the new combination pill or the three drugs separately, then switch. The goal is to see if the combinati…

This study looks at how the natural bacteria in your gut might change the way your body responds to rosuvastatin, a common cholesterol-lowering drug. Researchers will track changes in gut bacteria and cholesterol levels in 62 healthy volunteers over about 16 weeks. The goal is to…

This study follows 100 healthy adults aged 18 to 29 who have had Epstein-Barr virus (EBV) in the past. Researchers collect blood and saliva samples over 6 to 12 months to see when the virus becomes active again. No treatments or vaccines are given. The goal is to learn more about…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and non-invasive brain stimulation (TMS)…

This early-stage study tests a single injection of a new drug, RBD1119, in 32 healthy adults aged 18 to 65. The main goal is to check for side effects and see how the drug moves through the body. Participants are randomly assigned to receive either the drug or a placebo, and no o…

This study checks if a new drug called IBI3027 works the same as the approved drug Dupixent in healthy Chinese men. 180 volunteers will get a single shot of either drug and be monitored for 56 days. The goal is to see if the new drug is safe and reaches similar levels in the body…

This study was designed to measure DNA damage in cells from the mouth of smokers, vapers, and people who do not use tobacco or nicotine products. The goal was to find which types of damage might be more likely to cause oral cancer. However, the study was withdrawn before any part…

This study aims to establish normal reference ranges for white blood cells and granulocytes using a new device called the Liberty Analyzer WBC System. About 300 healthy adults aged 21 and older will provide blood samples. The results will help doctors interpret future test result…

This study looks at whether vitamin D levels in blood samples change when the samples are frozen or stored for different lengths of time. Researchers will compare fresh blood samples to stored ones from 80 healthy adults. The goal is to make sure labs can use stored samples witho…

This early-stage study tests the safety of a new drug called JADE101 in 32 healthy adults aged 18 to 55. Participants receive either a single dose of JADE101 or a placebo by injection under the skin. The goal is to see how the body handles the drug and whether it causes any side …

This early-stage study is testing a new drug, SL-325, in 72 healthy volunteers to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat any disease but to gath…

This study was designed to see how different drugs and drug combinations change mood, pain tolerance, and thinking skills in healthy adults aged 18 to 55. Researchers planned to measure how much of a drug people would take when it was free, and how much they would pay for it. The…

This study is creating a large community registry and biorepository with 50,000 volunteers from Cabarrus County and Kannapolis, NC. Participants provide health information and samples to help researchers better understand chronic diseases and improve future medicine. No direct tr…

This early-stage study looks at whether sirolimus, an FDA-approved drug, can increase blood flow to the brain in healthy adults aged 45-65. Some participants carry a gene (APOE4) that raises Alzheimer's risk, while others do not. The goal is to understand how the drug affects bra…

This early-stage study at Stanford University compares ketamine to a placebo (saline) during sedation in 15 healthy adults with major depressive disorder. The goal is to see how these drugs affect brain activity and experiences like dreams or thoughts. Researchers will use EEG to…

This early-stage study tests the safety of a new drug called ORKA-002 in 24 healthy adults aged 18 to 65. Participants receive a single dose and are monitored for side effects and how the drug moves through the body. The goal is to gather initial safety data, not to treat any dis…

This study checks whether a single dose of the experimental drug balinatunfib changes the heart's electrical activity in 48 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and another active drug in random order to compare effects. The goal is to ensure th…

This early-phase study tests the safety of a new drug, budoprutug, in 38 healthy adults aged 18-60. Participants receive either the drug or a placebo by injection or IV. The goal is to check for side effects and how the drug moves through the body, not to treat any disease.