HEALTHY VOLUNTEERS

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests a new drug called JUV-161 to see if it can prevent muscle loss in healthy adults aged 40 to 65 who have one leg immobilized for about 6 weeks. Participants will receive weekly injections of either the drug or a placebo. The study will measure muscle changes using…

This early-stage study tests whether the experimental drug TAK-781 is safe and tolerable in healthy volunteers and in people with primary sclerosing cholangitis (PSC), a chronic liver disease. The study also looks at how the body processes the drug. About 134 participants will be…

This early-stage study tests whether a new experimental medicine, NNC1679-0001, is safe and well-tolerated in healthy adults and people with type 2 diabetes. Participants receive a single injection of either the study drug or a placebo. The goal is to check for side effects and h…

This study tests an experimental drug called ALN-PNP for people with a type of fatty liver disease (MASLD) who have a specific gene variant. It is a first-in-human trial, meaning it is the first time this drug is given to people. The main goals are to check if the drug is safe, t…

This early-stage study tests the safety of a new drug called PRO-203 in 74 people. First, healthy volunteers receive a single injection to check for side effects. Then, people with systemic sclerosis (a chronic autoimmune disease causing skin and organ hardening) receive the drug…

This early-stage study tests an experimental drug, NNC4004-0002, in 60 adults with high uric acid levels but no symptoms. The main goal is to check safety and how the body handles a single injection. Participants receive either the drug or a placebo (saline) by chance. The study …

This early-stage study tests a new drug, CPTX2309, to see if it is safe and tolerable. It involves 64 healthy adults and people with moderate to severe rheumatoid arthritis or lupus. Researchers will monitor side effects, lab results, and immune responses to determine the drug's …

This early-stage study tests a new medicine called NNC0581-0001 in 48 adults with fatty liver and possible liver inflammation. Participants receive either the drug or a placebo as a monthly injection for 3 months. The main goal is to check safety and how the drug moves through th…

This early-stage study tests a new medicine called BMS-986470 in healthy volunteers and people with sickle cell disease. The main goal is to check if the drug is safe and how the body processes it. About 184 participants will receive either the drug or a placebo to gather initial…

This early-stage study tests whether IGT-303 is safe for people with chronic kidney disease (stages 2-3b) and healthy volunteers. About 94 participants will receive either the drug or a placebo, given as a shot under the skin or into a vein. The main goal is to check for side eff…

This early-stage study tests an experimental oral drug, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to treat or cure obesity. Participants are randomly assigned to recei…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults (including healthy volunteers) after injecting a radioactive tracer, aiming to see if shorter …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than standard scans to detect neuroendocrine tumors. About 200 healthy volunteers and people with tumors will receive a radioactive tracer and be scanned with a high-sensitivity PET machine. The go…

This study is testing a new, non-invasive camera that takes detailed pictures of the back of the eye using many colors of light. The goal is to see if this method can find early signs of common eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma…

This study tests a new vaccine (PCV21) that protects against 21 types of pneumococcal bacteria, which can cause pneumonia and ear infections. About 2,200 healthy infants will receive four doses starting at 2 months old. Researchers will check if the new vaccine is as safe and eff…

This early-stage study tests whether a device that sends mild electrical pulses to nerves and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions…

This study tests whether a 12-week program combining modern dance with mindfulness practices can improve psychological wellbeing, reduce stress, and boost life satisfaction in healthy adults. About 160 participants will take weekly dance-mindfulness classes, while another 160 ser…

This study tests if mulberry leaf extract capsules are safe for healthy people with slightly high blood sugar. 48 volunteers will take either the extract or a placebo three times a day for 8 weeks. Researchers will check blood counts, liver and kidney function, and blood sugar le…

This study tests whether a new software called Motion Reset can prevent or reduce cybersickness—symptoms like nausea, dizziness, and headache—in healthy adults using virtual reality. About 150 volunteers aged 18 to 60 will try different VR experiences and then play a commercial V…

This early-stage study tests a new weekly injection, NNC0497-0040, for safety and how the body processes it. It includes healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. Participants receive either the drug or a placebo fo…

This early-stage study tests a new drug called BGB-45035 for safety and how the body processes it. First, healthy volunteers (ages 18-55) will receive single or multiple doses. Then, people with autoimmune skin diseases like eczema or prurigo nodularis will receive the drug to ch…

This early-stage study tests a new drug called ABCL635, given as a shot under the skin, to see if it can safely reduce hot flashes in postmenopausal women. The study includes healthy men and women without symptoms, as well as women with moderate-to-severe hot flashes. Researchers…

This study looks at how taking itraconazole (a common antifungal) changes the way the body processes an experimental drug called ABBV-722. It involves 12 healthy adults and focuses on safety and drug levels in the blood. The goal is to gather information, not to treat any disease…

This study looks at whether adding nitrate to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy adults will eat these fortified foods and have their blood, saliva, and urine tested ove…

This study looks at how the body absorbs different versions of the drug emraclidine in 12 healthy adults. Participants take a single dose of each version and have their blood tested. The goal is to compare the drug levels and check for side effects, not to treat any disease.

This study is the first time LG-0317 is given to humans. It involves 100 healthy Chinese adults aged 18-45 to check the drug's safety and how the body processes it. The goal is to gather basic safety information before testing the drug for any disease.

This study checks if a Turkish version of a questionnaire that measures motion sickness in virtual reality works correctly. Researchers will ask 42 healthy adults to use VR and report symptoms like nausea or eye strain. The goal is to make sure the translated tool is accurate and…

This study uses a new technique called temporal interference (TI) to stimulate deep brain areas without surgery or affecting the surface of the brain. Researchers will measure brain activity with MRI scans in 30 healthy adults aged 18 to 50. The goal is to understand how deep bra…

This study looks at how a wearable robotic hip device affects the way healthy adults walk. Fifteen volunteers will walk with different levels of assistance from the exoskeleton. Researchers will measure step length, speed, muscle activity, and foot pressure to understand the devi…

This early-stage study tests a new drug called YN001 in 24 healthy adults aged 18 to 65. The goal is to see how the drug moves through the body and check for side effects. Participants receive a single dose and are monitored closely. This study does not treat any disease.

This early-stage study tests a new drug called KLA578-1 in 48 healthy volunteers aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either a single dose or multiple doses, and researchers will monitor for side eff…

This study collects blood samples from 1000 healthy adults aged 18 and older. The blood is used to improve tests and understand blood vessel and immune diseases. Participants get $50 per visit and can donate up to 10 years. No treatment or cure is involved.

This study tests a single dose of ITI-1284 in 42 healthy adults aged 18-55. Researchers will use brain scans to see how much of the drug attaches to certain brain receptors. The goal is to gather safety and drug-level information, not to treat any disease.

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers to help researchers understand blood diseases like aplastic anemia and viral blood infections. Participants must be 8 or older (18 for bone marrow). The samples are used only for lab research, …

This study looks at how social and cultural factors affect the way people express pain and how others assess it. Researchers will measure pain responses in healthy volunteers and test whether training can improve accuracy in judging others' pain. The goal is to understand and red…

This study explores whether virtual reality or mental imagery can replace traditional prism adaptation therapy for people with unilateral neglect after brain injury. Researchers will test these new methods on 480 healthy volunteers to see if they work similarly to the standard ap…

This early-stage study is testing how a new drug called repinatrabit interacts with several common medications, including birth control pills, metformin, rosuvastatin, carbamazepine, and methotrexate. About 48 healthy adults will take part to help researchers understand how these…

This early-stage study tests whether ARGX-124 is safe in healthy adults aged 18 to 65. Researchers will also measure how the drug moves through the body and how the immune system reacts. About 104 participants will receive either the drug or a placebo, and the study lasts up to 2…

This study screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like interviews, brain scans, and lab tests. The goal is to gather information to better understa…

This early-stage study in 18 healthy men aims to see how well the experimental drug MSP-2020 attaches to serotonin 2A receptors in the brain. Researchers will also measure drug levels in the blood and check for side effects. The goal is to understand the drug's action and safety …

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy volunteers aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does …

This study collects blood and urine samples from healthy volunteers and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the body. The goal is to develop new lab tests and better understand…

This study looks at how much of the drug KarXT (xanomeline and trospium) gets into the breast milk and blood of healthy women who are breastfeeding. Eight women will take KarXT and provide milk and blood samples over 24 hours. The goal is to estimate how much of the drug a nursin…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep patterns, and more in 2,000 healthy volunteers over 18. The goal is to bette…

This study screens healthy adults aged 18 and older to see if they qualify for future vaccine or treatment trials for infectious diseases. It collects basic health and demographic information to match volunteers with upcoming studies. No experimental treatment is given—it is pure…

This study looks at how people use their sense of hearing versus physical feeling when they speak. Healthy adults aged 18 to 45 will do speech tasks with altered audio feedback, sometimes with a visual display. Researchers will use a computer model to see if individual difference…

This early-stage study tests a single dose of an experimental injection called KL0011034 in 76 healthy Chinese volunteers aged 18-45. The main goal is to check safety and how the drug moves through the body, not to treat any disease. Participants will be randomly assigned to rece…

This early-phase study tests the safety of a new drug called RO7875913 in 40 healthy adults. Researchers will monitor side effects, how the drug moves through the body, and immune responses. The goal is to gather information for future studies, not to treat any disease.

This early-stage study is testing new forms of two drugs, KarX and KarT, in 72 healthy adults. Researchers want to see how the body absorbs and processes these new versions compared to the original drugs, and whether food changes their effects. The goal is to gather safety and do…

This early-stage study tests whether a single shot of GenSci161 is safe and how the body processes it. About 44 healthy adults aged 18-45 will take part. No treatment is given—this is purely to gather safety and drug information.

This study aims to collect detailed medical images (MRI and ultrasound) of the heart, liver, and blood vessels from 2,400 healthy volunteers across France. By linking these images with health data, researchers hope to establish normal ranges for different ages and sexes. This wil…

This study is testing a new device called pneuRIP that measures breathing without any needles or tubes. It uses soft bands placed around the chest and belly to track breathing rate and effort. Researchers will compare it to an existing monitor in 20 children – 10 healthy and 10 w…

This study looks at how healthy men absorb, break down, and get rid of a drug called E2086. Ten men will take a single dose with a radioactive marker so researchers can track it in blood, urine, and stool. No treatment or benefit is offered; the goal is simply to understand the d…

This early-stage study tests the safety and how the body handles a new drug called BMS-986521. About 106 healthy adults will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study aims to develop a new 4D-MRI technique that creates 3D movies of the lungs and liver during breathing. The goal is to help doctors better target tumors in cancer patients receiving radiation therapy, especially when tumors move with each breath. The study involves 100 …

This study is testing a new, more comfortable brain scanner that uses special sensors to measure brain activity. Researchers will compare this new device to a standard scanner in 80 healthy volunteers and athletes who have had a mild concussion. The goal is to see if the new scan…

This study aims to understand how genes and the environment influence children's eating behavior and health over time. Researchers will follow 1,500 children ages 8-17 for up to 6 years, using wrist monitors, smartphone surveys, and yearly check-ups including blood tests and X-ra…

This study collects blood, urine, saliva, and tumor tissue from 500 adults with or at risk for urothelial cancer (bladder, ureter, urethra). Researchers will analyze DNA and other molecular changes to understand what causes the cancer and how it responds to treatment. Participant…

This early-stage study is testing a new imaging agent called RAD301 in 9 people: healthy volunteers and patients with certain cancers like pancreatic, lung, or ovarian cancer. The goal is to see how the body handles the radiation from RAD301 and whether it is safe. No treatment i…

This study checks if the experimental drug BMS-986278 affects the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive multiple doses of the drug, a placebo, and a positive control in a crossover design. The main goal is to measure changes in heart…

This study looks at whether emergency room doctors can use ultrasound to clearly see the muscle layers in the belly wall, which is needed for a type of pain block called a TAP block. About 118 healthy adults will get an ultrasound scan of their abdomen. The goal is to see if body…

This study tests whether taking vitamin and mineral supplements for 12 weeks can improve skin health and how healthy people feel overall. About 120 healthy Chinese adults with low fruit and vegetable intake will take either the supplements or a placebo. Researchers will measure s…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the need for radiation or invasive tests. Researchers will compare these new MRI methods with standard tests like angiography in up to 4,000 adults, including healthy volunteers and…

This study looks at how the body absorbs a drug called empasiprubart when given as a shot under the skin using an autoinjector compared to through an IV. It involves 130 healthy adults aged 18 to 65. The goal is to understand the drug's behavior and safety, not to treat any disea…

This study looks at how healthy brains process social information, like understanding others' feelings. Researchers will use brain scans (fMRI) and brain wave recordings (EEG) to see which brain areas are active during social thinking tasks. The goal is to create a baseline of no…

This study collects blood, stool, saliva, and skin or mucus swabs from healthy volunteers ages 3 to 80. The samples are used to design and improve research tests for other studies. No treatment or medication is involved. Participants may be asked to give samples over 5 years.

This early-stage study tests whether LIFE-001 is safe and tolerable in 150 healthy adults aged 18 to 65. Participants receive single or multiple doses, and researchers monitor side effects and how the drug moves through the body. There is no expected treatment benefit for volunte…

This early-stage study tests a new drug called PBK_M2301 in 32 healthy adults aged 19 to 64. The goal is to measure how much of the drug gets into the blood and check for any safety issues. Participants receive a single dose of the drug and provide blood samples over time. No tre…

This study collects skin, blood, and other samples from people with skin diseases, their family members, and healthy volunteers. The goal is to understand what causes different skin conditions and find better ways to treat them. Participants provide samples like blood, skin biops…

This study aims to find better ways to measure what people eat, specifically sugar, using stable isotopes found in blood, hair, and fat. Sixty healthy adults will live at a research center for 13 weeks, eating controlled diets with different sugar levels. The goal is to develop o…

This study looks at how laser light bounces off different parts of the eye, like the cornea and retina. Researchers will measure the reflected light at various angles and colors in 20 healthy volunteers aged 18-40. The goal is to make laser-based eye exams and surgeries safer and…

This early-stage study is testing an experimental drug called CLYM116 in 48 healthy volunteers aged 18 to 60. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo as a shot under the skin. This study does …

This early-stage study is testing a new drug, Alpha-0261, for the first time in humans. The goal is to see if it is safe and how the body processes it. About 60 healthy adults aged 18 to 55 will receive a single dose of the drug or a placebo. No treatment or cure is being tested …

This study looks at whether a specific chest massage technique (intercostal mobilization) can improve breathing muscle strength, lung function, and walking speed in healthy but sedentary adults aged 18-30. Ninety volunteers will be split into three groups: one receiving the massa…

This study looks at whether longer or shorter training sessions help healthy adults better resist fatigue during prolonged exercise. Researchers will measure changes in cycling power and heart rate after a 4-hour ride. The goal is to understand how training duration affects physi…

This early-stage study tests a single inhaled dose of RJ026 in 84 people—42 healthy volunteers and 42 patients with interstitial lung disease (ILD). The goal is to see how the drug moves through the body and lungs, and to check for any safety issues. Participants will have blood …

This early-stage study tests the safety and tolerability of a new drug, LAD106, in healthy adults aged 18 to 45. Participants receive either single or multiple doses of the drug or a placebo. The goal is to understand how the drug moves through the body and its side effects, not …

This study aims to make MRI scans better by testing new imaging techniques. Researchers will scan healthy adults and current NIH participants to find the best settings for different body parts. Participants may have multiple scans over several years, with blood draws and possibly…

This study is testing a new device that uses light to measure pulse waves and estimate blood pressure. Researchers want to see if it works as well as current standard methods. The study involves 27 healthy adults aged 18 and older.

This study tests if biotin (vitamin B7) can be used to label platelets so doctors can track how long they survive after a transfusion. Healthy volunteers donate their own platelets, which are treated with biotin and stored for three days. A small amount of radioactive material is…

This study looks at how a drug called atumelnant affects and is affected by other medicines in healthy adults aged 19-55. It involves two groups of participants to measure drug levels and safety. The goal is to understand how the body processes these drugs together, which helps g…

This study looks at how two other drugs (itraconazole and rifampin) change the amount of AR-LDD in the blood of healthy adult men. 42 participants will take AR-LDD alone and then with each of the other drugs to see the difference. This is a phase 1 trial with no direct treatment …

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. TMS uses magnetic pulses to stimulate the brain and is already approved for depression. Researchers want to understand these brain changes to help design better treatments fo…

This study looks at whether a common grip strength device can reliably measure how well healthy people sense the force they apply with their hand. Researchers will ask 55 volunteers aged 18-24 to grip at a target force and then repeat it, measuring accuracy and consistency. The g…

This early-stage study tests whether a single dose of KLA478 is safe and how the body processes it. About 40 healthy adults aged 18-45 will receive the drug and be monitored for side effects and drug levels in the blood. No treatment benefit is expected; the goal is to gather saf…

This early-stage study is testing a new nasal spray called CHF6467 in 68 healthy adults to see if it is safe and how the body handles it. Participants will receive either the drug or a placebo through the nose, and researchers will monitor side effects, measure drug levels in blo…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This study aims to define normal scores on tests for spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking volunteers aged 20 to 89. The results will help doctors better diagnose spatial neglect in stroke patients by knowing w…

This early-stage study is testing whether adding D-serine to psilocybin (the active ingredient in magic mushrooms) can reduce its psychedelic effects while keeping it safe. Ten healthy adults aged 25-60 will receive one of two dose combinations and be closely monitored for side e…

This study collects blood plasma and white blood cells from healthy volunteers, HIV patients, and their relatives using a procedure called apheresis. The samples are used for laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH s…

This early-stage study is testing the safety of a drug called midomafetamine in 32 healthy adults aged 18 to 55. Participants receive either a standard or a higher dose and are closely monitored for side effects and how their body processes the drug. The results will help guide f…

This early-stage study is testing a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, given as an injection or IV. The study does not aim to treat any disease, but to gat…

This study looks at whether the artificial sweetener sucralose changes how the body absorbs and breaks down certain medicines. Researchers will give healthy overweight Black and Hispanic women either sucralose or a placebo for four weeks, then test how their bodies handle two com…

This study aims to understand how psychological factors, such as expectations, influence how we perceive pain. Healthy volunteers aged 18-50 will undergo brain scans and pain tests (heat or electric shocks) while their body responses are measured. The goal is to learn more about …

This study looks at how the drug KarXT is broken down in healthy adults who have different versions of a liver enzyme called CYP2D6. About 56 volunteers will take part to help researchers understand how fast or slow the drug leaves the body. The goal is to gather information, not…

This study looks at how a new drug called KarXT changes the way the body processes three other drugs: midazolam, fexofenadine, and digoxin. It involves 60 healthy adults and aims to measure drug levels in the blood. The results will help doctors understand if KarXT can be safely …

This early-stage study is testing a new drug, MT-251, in 70 healthy adults aged 19 to 55. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and no direct health benefit is expected. The results wil…

This study looks at how the brain decides whether to work hard for a reward. Researchers will use safe, non-invasive brain stimulation on 204 healthy adults aged 18-40 to see how brain connections influence motivation. The goal is to understand the brain circuits behind effort, w…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to see if it is safe, how long it stays in the body, and how it affects immune cells. About 96 participants will receive single or multiple doses to gather t…

This study looks at how a part of the brain called the posterior parietal cortex (PPC) helps us combine vision and body awareness to guide hand movements. Researchers will compare people with optic ataxia (a condition caused by PPC damage that affects reaching and grasping) with …

This early-phase study is testing the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 40 healthy adults. Participants take a single dose on an empty stomach and are monitored closely. The goal is to gather basic safety and drug-le…

This early-stage study tests whether ALN-4915 is safe and how it behaves in the body. About 44 healthy adults will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels, not to treat any disease.

This early-stage study tests a new drug called ZE74-0282 in 40 healthy adults aged 18-55. The main goal is to check its safety and how the body handles it, not to treat any disease. Participants receive either the drug or a placebo, and researchers monitor side effects and drug l…

This study will see if artificial intelligence (AI) can plan heart MRI scans as quickly and accurately as expert radiographers. Researchers will recruit 150 adults who are already scheduled for a heart MRI. During the scan, the AI will also plan a duplicate set of images, and doc…

This study aims to learn more about biomarkers—substances in blood and tissues—and how they relate to aging. Researchers will follow 900 healthy and frail adults over many years, collecting samples and performing tests like memory exams, scans, and biopsies. The goal is to find w…

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Thirty healthy adults aged 18-50 will receive TI stimulation while their brain activity is measured with fMRI. The goal is to understand ho…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes during physical practice, it may also help nearby brain areas used for language. The study will involve …

This study aims to understand what happens in the brain when someone has thought about or attempted suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people who recently had suicidal thoughts or attempts, those with p…

This study looks at how well different tablet versions of the drug BMS-986435 are absorbed by the body in 140 healthy adults. It also checks if eating food changes absorption. The goal is to find the best tablet form for future use, not to treat any disease.

This early-stage study is testing a new drug, AKB-9090, in about 70 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, given through a vein, in either a single dose or multiple doses over time. The main goal …

This study is testing how well certain brain and heart monitoring tools work in healthy people, Parkinson's patients, and those with paralysis. The goal is to prepare for future clinical trials by figuring out the best ways to collect data. No treatment is being tested—just the m…

This early-stage study is testing a single dose of an experimental drug called VV913 in 56 healthy Chinese men aged 18 to 45. The goal is to see if the drug is safe and how the body processes it. Participants are randomly assigned to receive either VV913 or a placebo, and no dire…

This early-stage study is testing the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, DWC202314) in 36 healthy adults. Participants take the drugs after a meal to see how food affects drug levels. The goal is to gather basic safety information, not…

This study looks at how a standard meal changes the way a new drug, VV119, moves through the body. It involves 16 healthy Chinese adults who will take the drug once with and without food. The goal is to understand food effects, not to treat any disease.

This study looks at how your internal body clock changes the way you experience time when you stay awake for 36 hours. Healthy adults aged 23 to 45 will stay in a controlled lab, awake the whole time, with everything kept constant. Every two hours, they will do short tests on tim…

This early-stage study is testing a single dose of an experimental drug called VV261 in 58 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. Participants will be randomly assigned to receive either VV261 or a placebo, and no …

This study tests whether a synbiotic supplement (a powder containing a sugar found in human milk) can increase helpful gut bacteria in healthy adults. One hundred healthy volunteers aged 18-99 who eat a typical Western diet will take the supplement twice daily for about 8 weeks. …

This study aims to create a large, detailed database of healthy Caucasian knees using advanced CT scans, X-rays, and ultrasound. Researchers will measure knee shape, ligament balance, and bone structure in 200 volunteers aged 20-35. The goal is to provide a reference for better u…

This study looks at how hidden factors, like how we see things or our age, affect the choices we make. Researchers will test 200 healthy adults to see if decision-making stays stable or changes with different tasks. The goal is to create a baseline to better understand decision-m…

This study collects white blood cells from healthy volunteers using a procedure called cytapheresis. The cells are used for lab research, not to treat any disease. Participants must be 18 or older and can donate every 56 days.

This early-stage study is testing a new drug called ALN-4285 in healthy adults to see if it is safe and how the body processes it. Participants receive a single injection of the drug or a placebo. The study is currently recruiting 76 volunteers.

This study looks at how a new drug, ABBV-722, changes the way the body processes five common medications. It involves 12 healthy adults who will take ABBV-722 along with a cocktail of other drugs. The goal is to check for side effects and measure drug levels in the blood to under…

This study tests a special imaging technique called adaptive optics to take very detailed pictures of the retina, the light-sensitive layer at the back of the eye. The goal is to see if this method can help doctors find and monitor eye diseases earlier than standard exams. Both p…

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tasks and brain imaging. The goal is to create a baseline for future studies on decision-making …

This study looks at how the brain's electrical activity synchronizes in people with fibromyalgia, a condition causing widespread pain. Researchers will compare brain scans of 150 fibromyalgia patients and healthy volunteers. They will also test if a gentle, non-invasive brain sti…

This study looks at whether taking cold showers regularly can improve how healthy adults cope with stress. About 120 people will either take a warm shower with a 30-second cold blast at the end, or just a warm shower, for four weeks. Researchers will measure stress levels, heart …

This study looks at how changing what you eat changes the energy your body uses to digest and process food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals. Researchers will measure their energy use in a special room to understand …

This study is an early-stage trial to see if the experimental drug ME3241 is safe and how the body processes it. About 104 healthy adults aged 18 to 55 will receive either the drug or a placebo. The main goal is to check for side effects and measure drug levels in the blood, not …

This study looks at how quickly proteins in the body are replaced, a process called protein turnover, in healthy adults of different ages. Participants will drink a safe form of heavy water for 21 days and undergo tests like muscle biopsies, imaging scans, and strength tests. The…

This early-phase study tests the safety of a new drug called SEP-479 in 150 healthy adults aged 21 to 60. Researchers will monitor side effects and measure how the drug moves through the body. The goal is to gather basic safety information, not to treat any disease.

This study looks at how energy drinks change the heart's electrical signals in healthy adults aged 18 to 40. Only 3 people will take part, and each will try 8 different drink combinations. The goal is to see if these drinks cause any heart rhythm changes, not to treat or cure any…

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Researchers will measure brain activity in 30 healthy adults using MRI scans. The goal is to understand how deep brain regions work and lay…

This study aims to see if completely inactive people can train for 18 months to complete a 100 km mountain ultra-marathon. Researchers will track how many participants stick with the program and finish the race, as well as monitor injuries and overall health. The goal is to under…

This study looks at how healthy adults use timing patterns in sounds and speech to predict what comes next. Researchers will use brain scans (EEG and MEG) and behavioral tests to understand these processes. The goal is to improve language learning, not to treat any disease. About…

This study is an early safety check for a new drug called HW241045, which may one day help treat a lung disease called IPF. Researchers are giving a single dose to 56 healthy adults to see if it is safe and how the body processes it. No treatment benefit is expected for participa…

This early-stage study tests whether a new drug, ZP9830, is safe and how it behaves in the body. About 124 healthy adults aged 18-45 will receive either the drug or a placebo. The goal is to check for side effects and learn how the drug is processed, not to treat any disease.

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples over a short period. The goal is to understand how the body handles this compound,…

This study looks at whether putting a special tape on the diaphragm (the main breathing muscle) before high-intensity interval training (HIIT) can improve physical performance. Thirty trained adults aged 18-35 will do an 8-week cycling program, with half also getting the tape. Re…

This study looks at how sleep improves visual learning. Ten healthy adults aged 18-30 will have their brains scanned with MRI while they sleep and do vision tests. The goal is to understand what happens in the brain during sleep that makes learning to see better possible.

This early-stage study tests whether a new drug called RO7806881 is safe and tolerable in healthy adults. About 128 participants will receive either the drug or a placebo, with doses increased gradually. The goal is to check for side effects and how the drug moves through the bod…

This study collects blood, bone marrow, urine, and tissue samples from people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, i…

This study tests a new medicine called B-3E07 against an approved drug, Forsteo, in healthy adult women. The goal is to see if the body handles both drugs similarly. Participants will receive a single dose of each drug in a random order and be monitored for safety and drug levels…

This early-stage study is testing an experimental drug called RO7763505 to see if it is safe and how the body processes it. About 196 participants, including healthy volunteers and people with stable coronary artery disease, will receive either the drug or a placebo. The goal is …