HEALTHY VOLUNTEERS

This study tested an experimental RSV vaccine in about 4500 adults aged 60 and older. Half received the vaccine and half received a placebo shot. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be serious in …

This study tested a single dose of an experimental meningitis vaccine (MenACYW) in 447 healthy people aged 12 months and older in Vietnam. The vaccine aims to protect against four types of meningococcal bacteria that cause serious infections like meningitis. Researchers measured …

This study tested several experimental versions of a quadrivalent (four-strain) flu vaccine in 210 healthy adults aged 18–30 and 50+. The goal was to see if changing one of the flu components (H3) or adding an adjuvant made the vaccine safer or triggered a stronger immune respons…

This study tested a new dengue vaccine in over 20,000 healthy children aged 4 to 16 years. The goal was to see if two doses could prevent dengue fever caused by any of the four dengue virus types. The vaccine was given as a shot under the skin and compared to a placebo. Results s…

This study looked at whether a booster dose of the MenQuadfi vaccine is safe and effective in healthy toddlers aged 12 to 23 months who had already received a different meningitis vaccine as babies. The goal was to see if the booster could strengthen their protection against meni…

This study tested Takeda's dengue vaccine in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the immune response against all four types of d…

This study tested a new vaccine that protects against five types of meningococcal bacteria (A, B, C, W, Y) in 1215 healthy teens and adults aged 10 to 25. The goal was to check the vaccine's safety and how well it triggers the immune system. Participants received the vaccine and …

This study tested a new meningitis vaccine (MenACYW) in 463 healthy adolescents aged 10-17. It compared the new vaccine to an existing one (Nimenrix®) and also looked at giving it together with HPV and Tdap-IPV vaccines. The main goal was to see if the new vaccine provides simila…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested a new mRNA flu vaccine in over 1,100 adults aged 50 and older. The goal was to see if it is safe and triggers a stronger immune response compared to standard flu shots. Participants received one injection of either the new vaccine or a licensed flu vaccine, and …

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults (65 and older) after they received their seasonal flu vaccine. The samples were sent to health agencies to help choose which flu strains to include in future vaccines. Participants …

This study looked at whether giving a high-dose flu vaccine and a Moderna COVID-19 booster at the same time is safe and works well for adults 65 and older. About 306 participants who had already received two Moderna COVID-19 shots took part. Researchers measured side effects and …

This study tested a new vaccine designed to protect against two respiratory viruses: RSV and hMPV. It involved 646 healthy adults aged 60 and older who received either the vaccine or a placebo. The goal was to see if the vaccine is safe and triggers a strong immune response, with…

This early-stage study tested an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV. Healthy adults aged 18 to 49 and 60 years and older received a single injection at different doses. The main goals were to check the vaccine's safety and …

This study tested a new meningitis vaccine (MenACYW) in 840 healthy infants and toddlers. The goal was to see if it works as well as an existing vaccine (Nimenrix) when given as two shots at 6 and 12 months of age. The trial measured immune response and monitored safety to suppor…

This study tested two different doses of an experimental H7 flu vaccine with an added booster (adjuvant) against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune response and was safe…

This early-stage study tested whether a new herpes vaccine called HSV529 is safe for people. 69 healthy adults aged 18 to 40, some with and some without herpes infection, received either the vaccine or a placebo. Researchers monitored for side effects and checked immune responses…

This early-stage study tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The goal was to check if the vaccine is safe and triggers an immune response. Participants received one shot at different dose levels, and researchers monitored for side effects an…

This study tested a new flu vaccine that includes an extra H3 virus strain, aiming to improve protection. About 400 healthy adults aged 18-49 and 60+ received either the new vaccine or a standard one. Researchers checked for side effects and measured immune responses over 3 weeks…

This study tested a new vaccine to protect infants and toddlers against four types of meningococcal bacteria that can cause meningitis and blood infections. About 1,500 healthy children in India and South Africa received the vaccine alongside their routine shots. Researchers chec…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, human metapneumovirus, and parainfluenza virus type 3. 270 healthy adults aged 18 to 49 received a single injection of one of the experimental vaccines or a comp…

This study tested whether a daily oral supplement called Immulina can strengthen the immune system's first line of defense against common cold and flu viruses. Nearly 500 healthy adults took either the supplement or a placebo for 20 weeks. Researchers measured changes in natural …

This study tested a new medicine called Mim8 for people with hemophilia A, a condition where blood doesn't clot properly. Mim8 is given as a shot under the skin to help prevent bleeding episodes. The trial included 275 healthy volunteers and people with hemophilia A, with or with…

This early-phase trial tested a new radioactive imaging agent called 18F-LNC1007 in 8 people—some healthy and some with a few small tumors. The goal was to see how the agent moves through the body, how much radiation it gives off, and if it is safe. Participants had PET/CT scans …

This study tested a new imaging agent called [18F]APN-1607 to see if it can help diagnose Alzheimer's disease. Researchers compared brain scans from 230 people, including those with Alzheimer's, mild cognitive impairment, and healthy volunteers. The goal was to see if the tracer …

This early-phase trial tested the safety of a new imaging agent called 68Ga-LNC1007 in 8 adults—some healthy and some with solid tumors. Participants received a single injection and were monitored for side effects and how the agent moved through the body. The goal was to see if i…

This study tested whether a high-dose flu vaccine could create a stronger immune response than the standard dose in adults aged 60 and older. Over 2,100 healthy seniors in Japan received either the high-dose or standard-dose vaccine. Results showed that the high-dose shot trigger…

This study tested seven different cosmetic creams to see if they could prevent skin darkening caused by high-energy visible light (like from the sun or screens). 33 healthy adults with fair to medium skin had creams applied to their back before being exposed to a specific blue-vi…

This early-phase study tested whether black raspberry confections could help prevent oral cancer in 67 healthy volunteers. Researchers measured how the body absorbed berry compounds and how they affected genes linked to cancer and inflammation. The goal was to find the best dose …

This study tested a high-dose flu vaccine in over 1,500 adults aged 60 and older. The goal was to see if the high-dose shot triggers a stronger immune response than the standard-dose flu shot. Results showed that the high-dose vaccine produced more antibodies against all four flu…

This study tested a new rabies vaccine in over 1,700 healthy children and adults in Thailand. The goal was to see if the new vaccine works as well as current rabies vaccines when given before exposure to the virus. Participants received either the new vaccine or one of two standa…

This study tested a new drug called MAM01 to see if it is safe and can help prevent malaria for at least 4 months. It involved 125 healthy adults and children living in parts of Africa where malaria is common. Researchers gave different doses to find the best one and watched for …

This study tested whether replacing some ingredients in cookies with quinoa could help healthy adults maintain normal blood fat and sugar levels, potentially lowering the risk of obesity and metabolic syndrome. Sixty healthy volunteers ate either a regular cookie or a quinoa-base…

This study looked at whether taking Rhodiola rosea (golden root) for 7 days can improve strength, endurance, and mental focus in healthy adults who already do resistance training. Twenty-seven men and women each tried a low dose, a high dose, a placebo, and a no-capsule control p…

This study tested whether combining a low dose of methylphenidate (a drug used for ADHD) with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in the 6-week program. The goal was to se…

This study tested three food supplements against a placebo in 132 healthy women aged 40-60 to see if they improve skin firmness, elasticity, and radiance. Participants took the supplements daily for three months, and researchers measured skin properties like firmness and cellulit…

This study looked at the best time to give a combination of two sedative drugs (remimazolam and remifentanil) during a painless stomach scope procedure. 342 healthy adults took part to see if changing the timing of the drugs could reduce side effects like coughing, body movement,…

This study tested whether TRPTI (oleoylethanolamide) can improve how healthy adults handle sugar. Nineteen participants took either 150 mg, 300 mg, or a placebo in random order, then had their blood sugar and insulin levels measured after a sugary drink. The goal was to see if TR…

This pilot study looked at whether the Feldenkrais Method, a gentle movement and awareness practice, could help reduce stress and improve well-being in 24 healthy but sedentary women aged 26 to 59. Participants either took part in eight daily 90-minute Feldenkrais sessions or ser…

This study looked at how 10 different drugs are broken down in the body. Ten healthy volunteers took the drugs, and researchers measured levels in the blood to create a personal metabolic profile. The goal was to learn more about drug processing, not to treat any disease.

This study tested a new method to measure how hard someone breathes while using a breathing mask (non-invasive ventilation). Twelve healthy adults took part. The goal was to see if a simple airway-occlusion technique could accurately assess breathing effort, which may help preven…

This early-stage study tested the safety of a new drug, SIM0278, in 60 healthy Chinese adults. Participants received either the drug or a placebo as a single or multiple injections. The goal was to check for side effects and measure how the drug moves through the body, not to tre…

This study tested a new drug called atumelnant in 21 healthy adults from Japanese and Caucasian backgrounds. The goal was to see how the drug moves through the body and if it is safe. Participants took the drug or a placebo by mouth once daily. This early-stage study does not aim…

This study compared two ways of giving the drug zilucoplan under the skin: a standard prefilled syringe and a new auto-injector device. Fourteen healthy adults received a single dose of each method to see if the drug levels in the blood were similar. The goal was to check if the …

This study looked at how many people are needed to find all the mistakes people might make when using the Zeneo® auto-injector. Sixty healthy volunteers, some familiar with auto-injectors and some not, used the device in different test settings. The goal was to improve device saf…

This study looked at how two common drugs (phenytoin and itraconazole) change the way the body handles BGB-16673. It involved 37 healthy adults aged 18-65. The goal was to measure drug levels in the blood, not to treat any disease.

This study looked at whether a 12-week strength and power training program could improve movement patterns, physical fitness, and leg strength in Chinese college sports dancers. Thirty healthy female dancers with at least one year of experience took part. They were split into two…

This early-stage study tested a new drug called BMS-986419 in 74 healthy volunteers to see if it is safe and how the body processes it. The study also checked if the drug affects the heart's electrical activity. Since participants were healthy, the goal was only to gather safety …

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This study tested how well risankizumab enters the body when given through an on-body injector compared to a standard prefilled syringe. It involved 260 healthy adults and measured drug levels and side effects. The goal was to see if the new injector works as well as the syringe,…

This study looked at the long-term safety of the malaria drug tafenoquine in 600 healthy adults. Participants took either tafenoquine or a placebo daily for three days, then weekly for 51 weeks. The main focus was on eye health, checking for any serious changes. The study did not…

This study tested how food and a common stomach-acid drug (rabeprazole) affect the amount of an experimental medicine called ZN-A-1041 in the blood. Twenty-four healthy adults took the drug under different conditions to measure absorption. The goal was to learn how to best take t…

This study tested a new drug called ENX-104 in 12 healthy adults. Researchers wanted to see how the drug moves through the body when given as a liquid or a tablet, and whether a high-fat meal changes its effects. The goal was to gather safety and processing information, not to tr…

This study looked at how the body absorbs different versions of the drug povetacicept in 136 healthy volunteers. The goal was to compare the drug's formulations and check for safety. No treatment was given—just observation of how the drug moves through the body.

This study looked at whether taking the acid-reducing medicine famotidine changes how the body processes a new drug called afimetoran. It involved 32 healthy adults and used a crossover design to compare drug levels with and without famotidine. The goal was to gather safety and d…

This early-stage study gave a single dose of ENX-104 to 10 healthy volunteers to see how well it binds to certain brain receptors (D2/D3), how safe it is, and how the body processes the drug. The goal was to gather important information for future research, not to treat any disea…

This study looked at whether a special MRI technique called T1rho can reliably measure hip cartilage in healthy volunteers. Thirty-one people without hip pain had two MRI scans 30 minutes apart. The goal was to find normal cartilage values and see if the measurements were consist…

This early-phase study tested the safety of a new drug called VRG50635 in 22 healthy adults aged 19 to 55. Researchers measured side effects and how the drug moves through the body. The goal was not to treat any disease but to gather essential safety data before future studies.

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers m…

This early-stage study tested a new drug called VNRX-7145 in 83 healthy adults to see if it is safe and how the body processes it. Participants received either a single dose or multiple doses over 10 days. The main goal was to check for side effects and measure drug levels in the…

This study looked at 100 healthy men to see if a common gene variation (called TaqIB) changes how well their 'good' HDL cholesterol works. The goal was to compare HDL's ability to remove cholesterol from cells in people with different versions of this gene. The findings could hel…

This early-stage study tested the safety and how the body handles two experimental antibodies (AZD5396 and AZD8076) in 61 healthy adults. Participants received the antibodies through injections followed by a mild electrical pulse to help the body produce them. The goal was to che…

This study tested whether a short session of neck stretching can lower blood pressure in 25 healthy adults. Researchers measured blood pressure, tissue stiffness, and heart rate before and after stretching. The goal was to see if stretching relaxes blood vessels and calms the ner…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and the brain's hippocampus in 66 healthy adults and people with depression. Participants took either the steroid or a placebo for three days and underwent memory tests and high-resolution …

This study involved 120 healthy volunteers (60 adults and 60 children) who tasted five different flavors of benzydamine HCl lozenges. They held each lozenge in their mouth for 10 seconds without swallowing, then rated its taste, aftertaste, and texture using a simple questionnair…

This study looked at how the painkiller oxycodone behaves in the body when given as a nasal spray versus an oral solution. Eight healthy adults took both forms in random order, and researchers measured drug levels in the blood and any side effects. The goal was to improve compute…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study is for research only and does not treat any disease. It looks at how safe a single dose of cenerimod is and how the body absorbs and breaks it down. Twenty healthy adults (10 Japanese and 10 Caucasian) will take part. The goal is to see if the drug works similarly in b…

This study looked at how complex our movements are by measuring finger-tapping patterns in 60 healthy volunteers. The goal was to understand normal sensorimotor behavior and see if these measurements could be useful in future clinical settings. No treatment was given; it was pure…

This study looked at how healthy adults remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI to understand which parts of the brain help us recall details. The goal was to learn more about memory and attention, not to treat …

This study tested how well two different pill forms of the drug rilzabrutinib are absorbed by the body, with and without food. Twenty-eight healthy adults aged 18 to 55 took single doses in four separate periods. The goal was to measure drug levels in the blood, not to treat any …

This study measured how much nicotine gets into the blood from an e-cigarette, a nicotine inhaler, and a regular cigarette. Twelve adult smokers each tried all three products in a random order. The goal was to understand the nicotine levels each product delivers, not to treat any…

This study checked if a wearable motion sensor (BTS G-sensor) can accurately measure how high people jump. Twenty-nine healthy women aged 18-35 did countermovement jumps while wearing the sensor and using a smartphone app. The goal was to see if the sensor gives results similar t…

This study measured oxygen and carbon dioxide levels in the throat of 14 healthy volunteers during different oxygen therapies (high-flow nasal cannula, face mask, and standard mask). The goal was to understand which method best delivers oxygen and removes carbon dioxide, especial…

This early-stage study tested the safety of a new drug called MF-300 in 100 healthy adults. Participants received either a single dose or multiple doses to see how the drug moves through the body and what side effects occur. The goal was to gather safety information, not to treat…

This study is for research only and does not treat any disease. It looks at how a single 16 mg dose of selatogrel is absorbed, broken down, and tolerated in 32 healthy adults—16 Japanese and 16 Caucasian. Participants stay in a clinic for 3-4 days and have follow-up visits over a…

This study tested a new pill that combines two drugs (zanubrutinib and sonrotoclax) used to treat blood cancers. 24 healthy adults took the pill to see how well it is absorbed by the body, both with and without food. The goal was to compare the combination pill to taking the two …

This study tested the safety and heart effects of a new drug called BMS-986278 in 42 healthy adults. Researchers measured side effects and how the drug affects heart electrical activity. The goal was to gather safety information for future studies, not to treat any disease.

This study looked at how repotrectinib, a cancer drug, changes the way the body processes other medications. Thirty healthy adults took repotrectinib along with a mix of common drugs like metformin and omeprazole. The goal was to measure drug levels in the blood to understand pot…

This study tested a non-invasive technique called transauricular vagus nerve stimulation (taVNS) in 44 healthy adults. Participants received a gentle electrical pulse to the ear for 60 minutes to see how it changes brain activity and the body's ability to handle pain. The goal wa…

This study looked at how two different versions of the drug centanafadine are absorbed by the body. 62 healthy adults took either a sustained-release tablet or an extended-release capsule. The goal was to measure drug levels in the blood, not to treat any disease.

This study looked at how the drug belumosudil affects certain proteins in the liver and gut that process other medications. Healthy men aged 18 to 55 took belumosudil along with other drugs to see how their bodies handled them. The goal was to gather safety and interaction inform…

This early-stage study tested a new oral drug called AN2-502998 in 72 healthy adults aged 18 to 55. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug le…

This study looked at whether adding motivation to mental imagery or watching actions could improve lower back strength in healthy adults. Forty people were split into four groups: some did mental imagery, some watched actions, and half of each group also got a motivational boost.…

This study looked at whether taking creatine and L-arginine together, just once, can improve short bursts of exercise and mental reaction time in healthy, active men. Eighteen men tried each supplement alone, together, or a placebo in random order. They did sprint tests, jump tes…

This early-phase study tested the safety and drug levels of BB-025, a potential reversal agent for the blood thinner BB-031, in 72 healthy adults aged 18–55. Participants received either BB-025 or a placebo, alone or after a dose of BB-031, and were monitored for 28 days. The goa…

This study tested a new biosimilar drug (MB04) against two versions of Enbrel in 141 healthy men. The goal was to see how the drugs move through the body and if they cause side effects or immune reactions. Participants received a single dose and had blood samples taken over sever…

This early-stage study tested a single dose of the experimental drug selonabant in 40 healthy adults aged 18 to 30. The main goal was to check for side effects and see how the body processes the drug. Participants were randomly assigned to receive either the drug or a placebo, an…

This study tested whether a new medicine called etavopivat, being developed for sickle cell disease, affects the heart's electrical activity. Thirty-three healthy adults received different doses of the drug, a placebo, or an approved heart medication. The goal was to check for an…

This study tested a new version of the allergy medicine fexofenadine (Allegra) to see if it works as well when taken with or without water compared to the current coated tablet. Twenty-five healthy adults took the drug in different ways under fasting conditions. The goal was to m…

This early-stage study tested the safety of a new drug, KINE-101, in 24 healthy adults. Participants received daily IV infusions for 7 days at different doses. The main goal was to check for side effects and how the drug moves through the body. No treatment benefit was expected s…

This study tested whether a new version of the drug dupilumab works the same as the current version in the body. It involved 182 healthy adults aged 18 to 65. Participants received a single injection of either the new or current drug, and researchers measured drug levels and side…

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body processes each version and check for side effects. Participants received a single injection and were monitored for about 17 weeks…

This study looked at 50 healthy adults to see if changing arm position makes veins in the armpit and collarbone area show up bigger on ultrasound. The goal was to find the best arm position for easier and safer vein access. Results help guide doctors when placing central lines.

This study looked at how a new drug called KarXT interacts with three common mood stabilizers (lithium, valproic acid, and lamotrigine) in 133 healthy adults. Researchers measured drug levels in the blood and checked for side effects. The goal was to understand if these drugs aff…

This study tested whether gentle electrical stimulation during naps can increase certain brain waves linked to emotional health. 72 healthy adults who nap regularly took part. Researchers measured brain activity, mood, and alertness to see if the stimulation helped. The goal was …

This early-stage study tested the safety and tolerability of Ginkgolide B injection in 36 healthy adults aged 18 to 45. Participants received single or multiple doses to see how the drug behaves in the body and what side effects occur. The goal was to gather safety data, not to t…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This study looked at how much of the drug deucravacitinib passes into the breast milk and blood of healthy women who are breastfeeding. Eight mothers took a single dose, and researchers measured drug levels in milk and plasma over time. The goal was to estimate how much of the dr…

This study tested whether two different injection devices deliver the same amount of the drug amlitelimab into the body. It involved 212 healthy adults aged 18 to 55. The main goal was to compare the drug levels in the blood and check for any safety issues after a single dose.

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. 80 healthy young adults were split into two groups: one walked outdoors in nature, the other walked indoors in a…

This study tested a 3D photography method called stereophotogrammetry to measure body shape without radiation. It included 199 people with scoliosis, chest wall deformities, obesity, and healthy volunteers. Participants had a physical exam and quick 3D photos of their bare torso.…

This early-phase study tested a new drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers to see if it is safe and how the body processes it. Researchers are exploring B-OT as a potential treatment for infectious diseases and cancer. Participants took the drug by mou…

This early-stage study looked at how a tablet form of the experimental drug ABBV-722 moves through the bodies of 11 healthy adults. Researchers measured drug levels in the blood to understand how the body processes it and whether taking it with food changes absorption. The goal w…

This study looked at how cooling the brain and timing brain stimulation with brain waves can change brain activity. Healthy adults wore a cooling cap or had brain waves measured while receiving mild magnetic pulses. The goal was to learn more about how the brain works, not to tre…

This early-stage study tested a new drug, AZD1163, in 108 healthy volunteers to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or IV. The main goal was to check for side effects and measure drug levels in the blood…

This study involved 13 healthy adult volunteers who received a single dose of an experimental drug called TAK-063. Researchers used brain scans to measure how much of the drug attached to a specific brain protein. The goal was to understand the drug's behavior in the brain, not t…

This study looked at whether L-lysine, a common amino acid, can change levels of aldosterone and cortisol—hormones that control salt balance and stress. Twenty healthy men took L-lysine or a placebo for 13 days, then switched. Researchers measured hormone changes during various t…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This study looked at how taking a drug called rilzabrutinib with or without food, and in different pill forms, changes its levels in the blood. Twenty-four healthy adults each took a single dose under different conditions. The goal was to gather information for future dosing, not…

This early-stage study tested the safety and how the body handles a new drug called SEP-631 in 120 healthy adults aged 18 to 60. Participants received either the drug or a placebo to check for side effects and measure drug levels in the blood. Since this is a Phase 1 trial in hea…

This study tested how a new drug called CS0159 interacts with other common drugs (rifampicin and itraconazole) and a high-fat meal in 32 healthy adults. The goal was to measure drug levels in the blood and check for side effects. This helps researchers understand how to use CS015…

This early-phase study tested a new antibody called AK1967 (Procizumab) in 24 healthy men to see if it is safe and how the body processes it. The antibody targets a protein that may worsen cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Th…

This study tested two new dissolvable forms of vonoprazan (a stomach acid reducer) to see how well they work compared to the standard tablet. Twenty-five healthy adults took single doses of each form, either without water or mixed with water and given via syringe. The goal was to…

This study looked at how genes influence thinking, emotions, and addictive behaviors in 847 adults, including healthy non-users, smokers, and people with substance use disorders. Participants gave a blood sample, filled out questionnaires, and did computer tasks. The goal was to …

This study looked at how collagen from drinks gets into the blood. Twenty-five healthy men drank different collagen products or a placebo. Blood samples were taken before and up to 4 hours after drinking to measure collagen building blocks. The goal was to see which products are …

This study tested the safety and how the body processes a new drug called nacresertib in 93 healthy adults. Participants took single or multiple doses by mouth, and researchers measured drug levels and side effects. The goal was to gather safety information, not to treat any dise…

This study tested two different tablet forms of an experimental drug called UCB0022 in 14 healthy adults. The goal was to see how well each form is absorbed into the body and to check for any safety issues. Participants took a single dose of each tablet on separate occasions, and…

This study looked at whether online nutrition workshops can help hospital employees switch to a more plant-based diet that is also better for the planet. 64 healthy adults working at a hospital took part. They were split into two groups: one got a 2-hour weekly digital program, t…

This study tested a new device called E-celsius, which is a pill you swallow that measures your body temperature from inside your digestive tract. It compared the pill's readings to standard temperature probes placed in the esophagus and rectum. The goal was to see if the pill is…

This study collected blood samples from 90 healthy volunteers—children aged 6 months to under 9 years and adults 65 and older—after they received the 2020-2021 flu vaccine. The samples were sent to experts at the WHO, CDC, and FDA to help decide which flu strains to include in fu…

This study tested a new ultrasound method to measure blood flow inside the shinbone of 30 healthy men. The goal was to see how bone blood vessels react to simple activities like squeezing a handgrip or having a blood pressure cuff tightened. The findings will help scientists unde…

This early-stage study tested the safety and tolerability of a new drug called LAD191 in 69 adults, including healthy volunteers and people with an autoimmune disease. Participants received either the drug or a placebo to check for side effects and how the drug moves through the …

This study looked at how the body processes vitamin C, especially how water intake changes vitamin C levels in the blood. 23 healthy adults followed a low-vitamin C diet and then took vitamin C pills and injections. Researchers measured vitamin C in blood and urine to understand …

This study tested several new versions of insulin lispro in 54 healthy volunteers to see how quickly the body absorbs and clears them, and whether they cause side effects. The goal was purely to gather safety and drug-level information, not to treat any disease. Participants were…

This early-stage study tested a new drug called SAR441344 in 56 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or infusion. The main goal was to monitor any side effects over several months.

This early-stage study tested a single dose of the experimental drug ORKA-001 in 24 healthy adults to see if it is safe and how the body processes it. The main goal was to check for side effects and measure drug levels in the blood. Since it involved healthy volunteers, no treatm…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This study looks at why certain drugs, like the antifungal voriconazole and the antibiotic doxycycline, can cause an exaggerated sunburn reaction called phototoxicity. Researchers will measure gene activity in skin samples from 62 participants (ages 8 and up) to better understand…

This study looked at how healthy adults' brains handle the decision to double-check their work. Using brain scans (fMRI and EEG), researchers aimed to pinpoint which brain areas are active during checking tasks. The goal is to better understand compulsive checking in conditions l…

This early-stage study tested a single dose of the experimental drug EA5 in 28 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either EA5 or a placebo, and neither they nor the doctors knew who got which. The goal …

This study looked at whether napping in different places (including a special SOMBOX module) helps healthy adults stay alert and drive better compared to just resting without sleep. Forty good sleepers aged 20-50 took part. Researchers measured driving errors, reaction times, sle…

This study tested a single dose of the experimental medicine etavopivat in 24 healthy Chinese adults. Researchers measured how the drug moves through the body and checked for side effects over about a week. The goal was to gather safety and dosing information before testing in pa…

This study looked at tissue samples from the tonsils, lymph nodes, and intestines of people with HIV and healthy volunteers. The goal was to measure how much virus and certain immune cells are present in these tissues during treatment. It did not test any new drug or treatment, b…

This study tested a new tablet form of Magne-B6 (magnesium and vitamin B6) against the current liquid version in 24 healthy adults. Participants took both forms on separate days, and researchers measured how much magnesium and vitamin B6 got into their blood and urine. The goal w…

This study looked at brain activity in 47 people (some with epilepsy, some healthy) using two non-invasive imaging methods (fMRI and MEG) at the same time as electrodes placed inside the brain. The goal was to better identify the area causing seizures and to map healthy brain net…

This study looked at how two different tablet versions of the drug BGB-43395 are absorbed by the body in healthy adults aged 18 to 65. It also checked if eating food changes how the drug works. The goal was to find the best tablet form and understand food effects, not to treat an…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The drug is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the dru…

This study looked at how a breast cancer drug called SAR439859 is absorbed, broken down, and eliminated by the body. Six healthy postmenopausal women took a single dose of the drug with a radioactive tracer to track its path. The goal was to understand the drug's metabolism and h…

This study checked if a specific gene change (CYP2C9*3) affects how well ibuprofen works and how tolerable it is after a molar tooth extraction. 200 healthy Pakistani adults took ibuprofen after their tooth removal, and researchers measured their pain levels and side effects. The…

This study tested two different pill forms of an experimental drug called PF-07976016 in 12 healthy adults. The goal was to measure how much of the drug gets into the blood after a single dose. No treatment was given — the study was only to help Pfizer decide which pill form to u…

This early-stage study tested a new oral drug called IPG1094 in 76 healthy adults aged 18 to 50. The main goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. This trial …

This study looked at how the liver affects the body's processing of cagrilintide, a drug being developed for weight management. It involved 32 participants with different levels of liver function and healthy volunteers. The goal was to measure drug levels in the blood, not to tre…

This study tested a new way to collect fluid from the skin using a tiny microneedle patch. Researchers compared samples from 20 healthy volunteers and people with eczema (atopic dermatitis) to see how much fluid could be collected and how well it was tolerated. The goal was to le…

This early-stage study tested the safety and tolerability of a new oral drug called MT-501 in 72 healthy adults aged 19 to 55. Participants received either single or multiple doses of the drug or a placebo. The goal was to check for side effects and how the drug moves through the…

This study looked at how brief periods of weightlessness during parabolic flights affect spatial memory and brain structure in 24 healthy adults. Participants completed computer-based memory tests and had brain scans before and after flying. The goal was to understand changes in …

This study gave 8 healthy men a single dose of a drug containing a tiny radioactive tracer to track how the drug leaves the body. Researchers measured how much of the drug came out in urine and stool over time. The goal was purely to understand the drug's elimination, not to trea…

This study tested a single injection of a new drug, NNC0582-0001, in 56 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo and were monitored for a year. The goal was to gather early safety and drug-level informat…

This early-stage study tested the safety and tolerability of a single dose of TRL345 in 16 healthy adults aged 18 to 65. The goal was to gather important safety data and understand how the drug moves through the body. Results will help design future studies in transplant patients…

This study looked at how vitamin E is absorbed and used in the bodies of 50 women, including those who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after meals with different amounts of fat and vitamin E. The g…

This study looked at how the drug golcadomide behaves in people with moderate or severe liver damage compared to healthy volunteers. A total of 29 adults took a single dose, and researchers measured drug levels and checked for side effects. The goal was to understand how liver pr…

This study tested a new imaging agent called GEH200521 (18F) in 22 healthy volunteers to see if it is safe and how it spreads in the body. Participants received the agent along with another injection, and researchers monitored side effects and imaging results. The goal was to gat…

This study tested a single dose of the drug teprotumumab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and to check for any side effects. Participants were randomly assigned to receive either the drug or a placebo, and no one knew whic…

This study aimed to collect detailed measurements of the spine and pelvis in 161 healthy adults using a special low-dose X-ray technology called EOS. By understanding what a normal, pain-free spine looks like, doctors hope to better diagnose and treat people with lower back pain.…

This study looked at 12 people with chronic bilateral vestibular hypofunction (a condition where the inner ear doesn't sense head movement properly) and 12 healthy volunteers. Researchers wanted to understand what triggers very fast eye movements (called covert saccades) that hel…

This study tested two different versions (a tablet and a capsule) of an experimental medicine called NDec, which is being developed for sickle cell disease. 44 healthy adults each took a single dose of both forms to see how the body absorbs them. The goal was to compare the two f…

This study looked at how a single injection of the experimental drug NNC0194-0499 behaves in people with different levels of liver function, from healthy to severely impaired. The drug is being developed for non-alcoholic fatty liver disease (NAFLD) and its more serious form, NAS…

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults aged 18-45. Researchers used PET scans to see how much of the drug reached and attached to a specific brain receptor (5-HT2A). The main goals were to measure receptor binding, drug l…

This early-stage study looked at how different versions of an experimental drug, BMS-986460, are processed by the body. Eighty-five healthy adult men took part to check safety and drug levels. The goal was to gather information, not to treat any disease.

This study looked at how the brain controls and adjusts quick eye movements called saccades, which help us see and interact with the world. Thirty-six healthy adults performed eye-tracking tasks inside an MRI scanner so researchers could see which brain areas were active. The goa…

This study looked at how mindfulness meditation and hypnosis affect the brain's sense of self. One hundred healthy adults underwent brain scans while performing tasks and reporting their experiences. The goal was to understand the brain areas involved in self-awareness during the…

This study looked at how light affects alertness and thinking in healthy adults after staying awake all night. 18 volunteers aged 18-40 were tested on fatigue, hormone levels, and mental performance. The goal is to find ways to help people with sleep problems stay sharp.

This study looked at how healthy babies' brains and behaviors change during their first year of life. Researchers used brain scans, EEG, and eye-tracking tests on 80 infants at 3, 6, and 12 months old. The goal was to understand normal brain growth and how early experiences shape…

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part to help understand if liver problems change drug levels. The results will guide dosing for pa…

This study gave 6 healthy men a single radioactive dose of venglustat to see how the drug moves through and leaves the body. Researchers measured the drug and its breakdown products in blood, urine, and stool. The goal was to understand the drug's metabolism and safety, not to tr…

This study looked at how the body absorbs and removes two medicines, TAK-881 and HyQvia, after a single injection under the skin. Thirty healthy adults aged 18 to 50 took part. The goal was to measure medicine levels in the blood, not to treat any disease.

This study looked at how the body processes a single dose of maribavir in healthy Japanese and Caucasian adults. Researchers wanted to see if there are differences in drug levels and safety between the two groups. The goal is to help determine the right dose for Japanese patients…

This early-stage study tested a new drug called NRS 033 in 24 healthy adults aged 18 to 55. The main goal was to check for side effects and measure how the drug moves through the body. Participants received either a single dose of the drug or a placebo. This study does not aim to…

This early-stage study tested a new experimental drug, NNC0113-6856, in 70 healthy men to see if it is safe and how the body processes it. Participants received either a single oral dose or an injection into the vein. The goal was to gather initial safety data and measure drug le…

This study looked at whether being in labour changes how fast the stomach empties a light meal. Researchers used ultrasound to measure stomach size in 43 women: those in labour (with or without epidural), pregnant women not in labour, and non-pregnant women. The goal is to help d…

This early-stage study tested the safety and tolerability of a new drug, LAD603, in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to see how the body processes it and if it causes side effects. The goal was to gather initial safety data, not …

This early-phase study tested the safety and how the body processes TAK-123 in 10 healthy Japanese men aged 20-45. Participants received a single intravenous infusion, and researchers measured drug levels in the blood and monitored for side effects. The study was completed and pr…

This study used a special brain scan (PET imaging) to look at how a chemical messenger called glutamate works in the brains of people with autism, people with Fragile-X syndrome, and healthy volunteers. The goal was to better understand brain signaling differences in these condit…

This early-stage study tested the safety and tolerability of a single injection of AJ302-IM in 57 healthy adults. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug moved through the body. The goal was not to treat any dise…

This early-stage study tested a single dose of the experimental drug ALN-AGT01 RVR in 42 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The study is complete and focused on side effec…

This early-stage study tested a new medicine, NNC0581-0001, in 48 healthy adults and people with fatty liver (hepatic steatosis). The main goal was to check safety and how the drug moves through the body after a single injection. Participants were randomly assigned to receive the…

This study looked at how taking a new drug called vamifeport with or without food changes the amount that gets into the blood. 28 healthy adults took the drug twice, once with food and once without, to compare. The results will help doctors decide how to take the medicine in futu…

This study looked at how healthy men absorb, break down, and get rid of a single dose of the drug JNT-517. Eight participants gave blood, urine, and stool samples so researchers could measure the drug and its byproducts. The goal was purely to understand the drug's behavior in th…

This study looked at whether healthy adults can safely digest protein from purple bacteria. Twelve participants ate a dairy product with or without purple bacteria on separate days, and researchers measured their blood amino acid levels and other metabolic markers over four hours…

This study looked at how much nicotine gets into the bloodstream from different oral nicotine pouches. Twenty-seven healthy adults who already use snus or nicotine pouches tested four products. Researchers measured nicotine levels in the blood and how much nicotine was left in th…

This early-stage study tested a new drug, EI1071, in 58 healthy adults to see if it is safe and how the body processes it. Participants received either single or multiple doses of the drug or a placebo. The main goal was to check for side effects and measure drug levels in the bl…

This study tested a new microneedle device for giving TB skin tests, aiming to make them easier to perform and more consistent than the traditional method. It involved 59 healthy volunteers, some with a positive TB skin test and some without. Researchers also tested a special cam…

This study looked at how eating too much at different times of day affects inflammation and metabolism in healthy adults. Researchers measured over 500 markers in blood samples to see if evening overeating is worse than daytime overeating. The goal is to better understand the bod…

This study tested how well healthy adults tolerate a new drug called TAK-881, given as an infusion under the skin. 64 participants received one or more doses to see if they could complete the infusion without side effects. The goal was to gather safety and dosing information, not…

This study tested how well vitamin A is absorbed from fortified bouillon cubes compared to an oil-based supplement. Fifty-eight healthy women consumed different vitamin A formulations in broth, and researchers measured vitamin levels in their blood. The goal is to see if adding v…

This study looked at whether a 12-week exercise program designed around students' personal interests (like team games or fitness challenges) could help them exercise more regularly and improve their physical fitness compared to standard physical education. Over 500 college studen…

This study looked at how aging cells appear around small skin wounds in healthy adults. Researchers compared younger (ages 20-39) and older (70+) volunteers to see if there are differences. Participants had small skin samples taken from their arms over three visits. The goal is t…

This study looked at how two drugs—Roflumilast (used for COPD) and Sitagliptin (used for diabetes)—affect blood sugar and gut hormones in 29 healthy adults aged 21-55. Participants took the drugs alone or together and had their blood tested after a meal. The goal was to understan…

This study tested two different versions of an inhaled drug (TPIP) in 42 healthy adults to see how much of the drug gets into the blood. Participants inhaled a single dose of each version on separate days. The results help researchers understand which formulation works better for…

This study looked at how two drugs that act on the body's endocannabinoid system affect insulin production and action. 45 healthy men aged 21-55 took part. The goal was to better understand insulin regulation, which could lead to new diabetes treatments in the future.

This study looked at whether the experimental drug EB-1020 could be abused like other stimulants. It involved 80 healthy adults who occasionally use stimulants recreationally. Participants received single doses of EB-1020, a placebo (dummy pill), or d-amphetamine (a known stimula…

This study looked at how doing isometric (static) exercises for the thigh muscles at different knee angles affects balance, joint awareness, and daily movements like climbing stairs. 44 healthy adults aged 18-30 took part in an 8-week program. The goal is to find the best knee an…

This early-stage study looked at how two drugs, epaminurad and C2406, affect each other in the body. It involved 18 healthy adults aged 19 to 50. The goal was to measure drug levels in the blood and check for any safety concerns.

This early-stage study tested the safety and how the body handles a new drug called ITI-333. It involved 32 healthy adults aged 18 to 45 who took either the drug or a placebo daily for 14 days. The goal was to check for side effects and measure drug levels in the blood, not to tr…

This study tested whether a non-invasive imaging technique could observe tiny blood vessels (microcirculation) in healthy volunteers during brief periods of weightlessness created by parabolic flights. The goal was to understand how the cardiovascular system adapts to space condi…

This early-stage study tested a new drug called KINE-101 in 40 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single dose, either through an IV or a shot. The goal was to check for side effects and measur…

This early-stage study tested the safety of a new drug, NAV-240, in 24 healthy adults. Participants received either the drug or a placebo to see what side effects might occur. The goal was to gather initial safety information, not to treat any disease.

This early-stage study tested the safety and tolerability of a new drug called AG-181 in 88 healthy adults. Participants received either single or multiple doses of the drug or a placebo. The goal was to see how the body processes the drug and whether it causes any side effects. …

This early-stage study tested the safety of a new drug called ARGX-213 in 88 healthy adults. Researchers also measured how the drug moves through the body and how it affects immune markers. The goal was to gather basic safety information, not to treat any disease.

This study checked if a dietary supplement made from silver fir branches, called Belinal®, is safe for the liver and kidneys. Fifteen healthy adults took the supplement daily for two weeks. Researchers measured blood markers of liver and kidney function at several points to see i…

This study looked at how a new drug called linaprazan glurate interacts with common antibiotics (clarithromycin, amoxicillin) and bismuth in 56 adults. Some participants were healthy and H. pylori-negative, while others had H. pylori infection. The goal was to measure drug levels…

This study looked at whether an updated mRNA COVID-19 vaccine causes a rise in a heart enzyme called troponin, which can signal heart stress. About 1000 healthy volunteers aged 12 to 30 received either the vaccine or a placebo, then switched groups later. Researchers measured tro…

This study tested how the drug risankizumab moves through the body when given by a prefilled pen compared to a traditional syringe. It involved 59 healthy adults and measured drug levels and side effects. The goal was not to treat a disease but to gather information for future us…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18 to 55. Participants took the drugs for several days and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels…

This early-stage study tested the safety and tolerability of a new drug called MT-701 in 46 healthy adults aged 19 to 55. Participants received either the drug or a placebo to check for side effects and how the body processes the drug. Since this is a first-in-human trial, there …

This study looked for better ways to measure what people eat by checking for natural markers in blood and hair. Fifty-nine healthy men followed special diets for 12 weeks while researchers tracked changes in these markers. The goal was to see if these markers can reliably show ho…

This study looked at how the injection site (upper arm, thigh, or abdomen) affects the amount of KAI-9531 that enters the bloodstream. It involved 51 healthy volunteers with a range of body mass indices. The goal was to understand if different injection spots change drug levels, …

This study tested a new drug called HD-P023 in 40 healthy adults to see how it compares to taking two diabetes medicines (teneligliptin and empagliflozin) together. The goal was to measure how the body absorbs and processes the drugs, not to treat any disease. Participants were h…

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database of normal gait patterns. Researchers used sticky electrodes on leg muscles to record muscle activity while children walked back and forth. The goal was to establish what typica…

This study looked at how different types of feedback—like social praise or money—affect decision making in 76 healthy adults. Researchers used brain scans and mild electrical stimulation to understand which brain areas are involved. The goal is to apply this knowledge to help peo…

This study looked at how much nicotine gets into the body from five types of blu disposable e-cigarettes compared to a regular cigarette. Twenty adult smokers who smoke at least 10 cigarettes a day took part. Researchers measured nicotine levels in the blood and asked about their…

This study looked at whether giving growth hormone can improve how the immune system works in healthy men aged 25 to 50. Participants received either growth hormone or a placebo through a small pump under the skin. The goal was to see if the hormone could reverse age-related immu…

This study looked at how a new drug called OPC-167832 interacts with other medicines in 24 healthy adults. Researchers measured how the drug is processed when taken with a common antifungal or a seizure medicine. The goal was to understand safety and dosing, not to treat any dise…

This early-stage study tested a new drug called TAK-004 in 121 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as an injection under the skin. The study did not aim to treat any disease, but to gather important…

This study was the first time a new drug, VIS954, was given to humans. The main goal was to see if it is safe and how the body handles it. 54 healthy adults received either the drug or a placebo. Researchers monitored for side effects and measured drug levels in the blood.

This study looked at how genetic differences affect the way the body activates a common blood pressure medication (enalapril). 21 healthy volunteers took the drug, and researchers measured how well their bodies converted it into its active form. The goal is to understand why some…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…