HEALTHY VOLUNTEERS

This study tested a new meningitis vaccine (MenACYW) in 463 healthy adolescents aged 10 to 17. It compared the new vaccine to an existing one (Nimenrix®) and also checked safety when given alongside HPV and Tdap-IPV vaccines. The goal was to see if the new vaccine provides simila…

This study tested Takeda's dengue vaccine in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo three months apart. The main goals were to check for side effects and measure the body's immune response to the vaccine.

This study tested a new vaccine (MenACYW) against an existing one (Nimenrix) to prevent meningococcal disease, a serious infection that can cause meningitis. About 840 healthy infants and toddlers received two shots—one at 6 months and another at 12 months. The goal was to see if…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, human metapneumovirus, and parainfluenza virus type 3. 270 healthy adults aged 18 to 49 received a single shot of one of the vaccine formulas. Researchers monito…

This study tested a new medicine called Mim8 for people with hemophilia A, a condition where blood does not clot properly. Mim8 is injected under the skin to replace the missing clotting factor and prevent bleeding episodes. The trial included 275 healthy volunteers and people wi…

This early-phase trial tested an experimental imaging agent called 18F-LNC1007 in 8 people—healthy volunteers and cancer patients with a small number of tumors. The goal was to see how the agent spreads through the body, how much radiation it gives off, and whether it is safe. Pa…

This study looked at whether taking Rhodiola rosea (golden root) for 7 days can improve exercise performance and thinking skills in healthy adults who already lift weights. 27 men and women completed four 7-day periods: no capsule, placebo, low-dose, and high-dose Rhodiola. On th…

This study looked at whether three different food supplements can improve skin firmness, elasticity, and radiance in healthy women aged 40 to 60. Over 130 women took the supplements or a placebo daily for three months. Researchers measured skin properties like firmness, density, …

This study looked at how oxycodone, a painkiller, is absorbed and processed by the body when given as a nasal spray or an oral solution. Eight healthy adults took a single dose of each form on separate days. The goal was to gather data to improve computer models that predict how …

This study looked at whether L-lysine, a common amino acid, changes levels of the stress hormones aldosterone and cortisol in healthy men. Twenty male volunteers took L-lysine or a placebo for 13 days, then switched. The goal was to understand how the body controls these hormones…

This study tested whether a gentle electrical current applied to the brain during a nap can increase specific sleep brainwaves and improve emotional well-being. 72 healthy adults who nap regularly took part. Researchers measured brain activity, mood, and alertness to see if the s…

This study looked at how many people are needed to find most of the mistakes people make when using a medical device called Zeneo®. Researchers tested 60 healthy volunteers, some who knew about auto-injector pens and some who didn't. The goal was to improve future device testing,…

This study tested a single 4 mg dose of cenerimod in 20 healthy volunteers (10 Japanese, 10 Caucasian) to see how safe it is and how the body handles it. It was not meant to treat any disease. Participants stayed in the clinic for 4 days and had follow-up visits over about 75 day…

This study tested whether two different injection devices deliver the same amount of the drug amlitelimab into the body. It involved 212 healthy adults aged 18 to 55. The goal was to check safety and how the drug behaves, not to treat any disease.

This study looked at whether giving growth hormone can improve how the immune system works in healthy men. The researchers wanted to see if the hormone, which naturally drops with age, could help the body fight infections better. Sixty-six men between 25 and 50 took part, receivi…

This early-stage study tested different versions of an experimental drug called BMS-986460 in 85 healthy adult men. The goal was to see how safe each version is, how the body processes it, and which form is absorbed best. No treatment was given—just careful monitoring to gather i…

This study looked at how a new medicine called etavopivat affects the heart's electrical activity. It involved 33 healthy adults aged 18 to 55. Participants received different doses of the medicine, a placebo, or an approved heart drug to compare effects. The goal was to ensure t…

This early-stage study tested the safety of a new drug called NRS 033 in 24 healthy adults aged 18 to 55. Participants received either a single dose of the drug or a placebo, and researchers monitored side effects and how the drug moved through the body. The goal was to gather sa…

This study looked at how the drug maribavir is absorbed and processed in healthy Japanese and Caucasian adults. 24 participants took a single oral dose to compare safety and drug levels in the blood. The goal was to see if the drug behaves differently between the two groups and a…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults (65 and older) after they received their seasonal flu vaccine. The samples were sent to health agencies to help decide which flu strains to include in future vaccines. No new treatm…

This study looked at how pleasant five different flavors of benzydamine HCl lozenges taste. 60 healthy adults and 60 healthy children each held a lozenge in their mouth for 10 seconds without swallowing, then rated its taste, aftertaste, and texture using a questionnaire with a 7…

This early-stage study tested a drug called TAK-123 in 10 healthy Japanese men to see how the body processes it and if it causes side effects. The goal was to gather safety and drug-level information, not to treat any disease. Participants received a single intravenous dose and w…

This study measured how quickly nicotine enters the bloodstream from three different products: an electronic vapor product (e-cigarette), a nicotine inhaler, and a regular cigarette. Twelve healthy smokers took part. The goal was to understand the nicotine levels each product del…

This study aimed to understand how the immune system reacts to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to learn more about the body's defense response, not to…

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults aged 18-45. Researchers used PET brain scans to see how much of the drug attached to a specific brain receptor (5-HT2A) and checked safety and drug levels in the blood. The goal was …

This study looked at how complex our natural movements are by having 60 healthy volunteers perform a tapping test. Researchers measured patterns in their performance to understand sensorimotor behavior better. The goal was to explore whether these measurements could one day help …

This study gave 8 healthy men a single dose of OPC-167832 containing a tiny radioactive marker. Researchers measured how much of the drug came out in urine and stool over time. The goal was simply to understand how the body processes and eliminates the drug, not to treat any dise…

This early-stage study tested the safety and tolerability of a new drug called LAD603 in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to see how the body processes it and whether it causes side effects. The study is complete and provides fou…

This early-stage study tested the safety and how the body handles a single dose of ALN-AGT01 RVR in 42 healthy adults. Participants were randomly assigned to receive either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood and urin…