Heart enzyme levels tracked after updated mRNA shot in 1,000 youth
NCT ID NCT06634797
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 4 study tested whether an updated COVID-19 vaccine (mRNA-1273.712) affects heart muscle in healthy people aged 12 to 30. Researchers measured a heart enzyme called troponin in 1,000 participants who received either the vaccine or a placebo. The goal was to see if the vaccine causes any temporary heart stress, helping to understand its safety profile in younger populations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mRNA-1273.712 vaccine
- What this could lead to
- If successful, this could provide reassurance that the updated mRNA vaccine does not cause heart muscle injury in young people.
- What could go wrong
- This is a completed safety study, not designed to prove the vaccine works. Results may not apply to other age groups or vaccine types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Velocity Clinical Research, Abilene
Abilene, Texas, 79606, United States
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Velocity Clinical Research, Albuquerque
Albuquerque, New Mexico, 87107, United States
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Velocity Clinical Research, Anderson
Anderson, South Carolina, 29621, United States
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Velocity Clinical Research, Banning
San Bernardino, California, 82408, United States
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Velocity Clinical Research, Boise
Meridian, Idaho, 83642, United States
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Velocity Clinical Research, Cincinnati
Cincinnati, Ohio, 45246, United States
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Velocity Clinical Research, Cincinnati, Blue Ash
Blue Ash, Ohio, 45242, United States
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Velocity Clinical Research, Cleveland
Beachwood, Ohio, 44122, United States
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Velocity Clinical Research, Covington
Covington, Louisiana, 70433, United States
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Velocity Clinical Research, Durham
Durham, North Carolina, 27701, United States
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Velocity Clinical Research, Grand Island
Grand Island, Nebraska, 68803, United States
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Velocity Clinical Research, Gulfport
Gulfport, Mississippi, 39503, United States
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Velocity Clinical Research, Huntington Park
Huntington Park, California, 90255, United States
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Velocity Clinical Research, Lafayette
Lafayette, Louisiana, 70508, United States
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Velocity Clinical Research, Lincoln
Lincoln, Nebraska, 68510, United States
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Velocity Clinical Research, New Orleans
New Orleans, Louisiana, 70119, United States
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Velocity Clinical Research, Omaha
Omaha, Nebraska, 68134, United States
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Velocity Clinical Research, Phoenix
Phoenix, Arizona, 85006, United States
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Velocity Clinical Research, Salt Lake City
West Jordan, Utah, 84088, United States
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Velocity Clinical Research, San Diego
La Mesa, California, 91942, United States
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Velocity Clinical Research, Savannah
Savannah, Georgia, 31406, United States
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Velocity Clinical Research, Syracuse
East Syracuse, New York, 13057, United States
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Velocity Clinical Research, Valparaiso
Valparaiso, Indiana, 46383, United States
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Velocity Clinical Research, Washington DC
Washington D.C., District of Columbia, 20016, United States
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