Gene study aims to personalize common heart drug
NCT ID NCT03051282
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how genetic differences affect the activation of enalapril, a common blood pressure medication. Researchers gave 21 healthy volunteers enalapril for a week and measured drug levels in their blood. The goal was to see if a specific gene variant (G143E) changes how the body processes the drug, which could lead to more personalized dosing in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
enalapril
What this could lead to
If successful, this could help doctors personalize ACE inhibitor dosing based on a person's genetics, improving effectiveness and reducing side effects.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. Results may not translate to real-world treatment or account for other factors affecting drug response.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Michigan
Ann Arbor, Michigan, 48109, United States