Can a shot stop muscles from shrinking when your leg is in a cast?

NCT ID NCT07397468

Recruiting now Disease control Sponsor: Juvena Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental drug called JUV-161 in healthy volunteers aged 40 to 65 who will have one leg immobilized for several weeks. The goal is to see if the drug can prevent muscle wasting (atrophy) and is safe. Participants receive weekly injections of either JUV-161 or a placebo for about 6 weeks, with muscle changes tracked by MRI and blood tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JUV-161 (an experimental drug injected under the skin)
What this could lead to: If it works, this could point toward a treatment to prevent muscle wasting in people who are temporarily unable to move a limb.
What could go wrong: This is an early-phase trial with only 36 healthy volunteers, so results may not apply to patients. The drug's safety and effectiveness are still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Locations

New Zealand Clinical Research
RECRUITING

Auckland, 1010, New Zealand
New Zealand Clinical Research
RECRUITING

Christchurch, 8011, New Zealand

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