Scientists track protein replacement across the lifespan with heavy water

NCT ID NCT06269653

Recruiting now Knowledge-focused Sponsor: National Institute on Aging (NIA) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how quickly proteins in the body are replaced, a process called protein turnover, in healthy adults aged 20 and older. Participants drink heavy water for 21 days and undergo tests including muscle, skin, and fat biopsies, imaging scans, and strength tests. The goal is to understand how aging changes protein turnover, which could inform future health research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deuterium oxide (heavy water)
What this could lead to: If successful, this could help scientists understand how aging affects protein turnover, potentially pointing toward ways to maintain health in older age.
What could go wrong: This is an early observational study with only 75 healthy volunteers, so results may not apply to everyone. It does not test any treatment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Locations

National Institute of Aging, Clinical Research Unit
RECRUITING

Baltimore, Maryland, 21224, United States

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