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Gene type may change how KarXT works in your body

NCT ID NCT07204418

Recruiting now Knowledge-focused Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study looks at how different versions of a liver enzyme (CYP2D6) affect the breakdown of xanomeline, one part of the drug KarXT. About 56 healthy volunteers with four different metabolism types will take KarXT and have their blood tested. The goal is to see if people who process drugs quickly or slowly have different drug levels, which could guide future dosing recommendations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
KarXT (xanomeline and trospium chloride)
What this could lead to
If successful, this study could help doctors personalize dosing of KarXT based on a person's genetic metabolism, improving safety and effectiveness for conditions like schizophrenia.
What could go wrong
This is an early Phase 1 study in healthy volunteers, not patients. It only measures drug levels and safety, not whether the drug works for any disease. Results may not apply to real-world patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • Anaheim Clinical Trials

    RECRUITING

    Anaheim, California, 92801, United States

    Contact Phone: •••-•••-••••

  • ICON - Lenexa

    RECRUITING

    Lenexa, Kansas, 66219-9746, United States

    Contact Phone: •••-•••-••••

  • ICON Development Solutions

    RECRUITING

    San Antonio, Texas, 78209, United States

    Contact Phone: •••-•••-••••

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