New drug BMS-986470 enters human trials for sickle cell disease

NCT ID NCT06481306

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests a new drug called BMS-986470 in healthy volunteers and people with sickle cell disease. The goal is to check its safety, how the body processes it, and whether it might help control the disease. The trial is in early phases and involves about 184 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BMS-986470
What this could lead to: If successful, this could point toward a new treatment option to control sickle cell disease symptoms and complications.
What could go wrong: This is an early phase 1/2a trial with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to show benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA, SICKLE CELL HEALTHY VOLUNTEERS

Contacts and locations

Locations

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
RECRUITING

Marseille, 13385, France
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
CHU Strasbourg-Hautepierre
RECRUITING

Strasbourg, 67098, France
Hôpital Universitaire Necker Enfants Malades
RECRUITING

Paris, 75015, France
Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
King's College Hospital
RECRUITING

London, London, City of, SE5 9RL, United Kingdom
Local Institution - 0001
ACTIVE_NOT_RECRUITING

Lenexa, Kansas, 66219, United States
Local Institution - 0005
NOT_YET_RECRUITING

Leeds, LS9 7TF, United Kingdom
Local Institution - 0009
NOT_YET_RECRUITING

Verona, 37134, Italy
Local Institution - 0011
NOT_YET_RECRUITING

Milan, Lombardy, 20122, Italy
Local Institution - 0024
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Local Institution - 0027
NOT_YET_RECRUITING

Greenville, South Carolina, 29605, United States
Local Institution - 0028
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Local Institution - 0029
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0030
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
Local Institution - 0032
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Local Institution - 0033
NOT_YET_RECRUITING

Greenville, North Carolina, 27834, United States
Local Institution - 0034
NOT_YET_RECRUITING

Chicago, Illinois, 60612, United States
Local Institution - 0037
NOT_YET_RECRUITING

Padua, 35128, Italy
Local Institution - 0044
NOT_YET_RECRUITING

London, Greater London, SE19RT, United Kingdom
Local Institution - 0047
NOT_YET_RECRUITING

London, W12 0HS, United Kingdom
Local Institution - 0050
NOT_YET_RECRUITING

Vancouver, British Columbia, V621Y6, Canada
Local Institution - 0051
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Local Institution - 0061
NOT_YET_RECRUITING

Créteil, 94000, France
Local Institution - 0064
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Thomas Jefferson University - Medicine/GI and Hepatology
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
University Hospitals Sussex NHS Foundation Trust
RECRUITING

East Sussex, Brighton And Hove, BN2 1ES, United Kingdom
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California San Diego - La Jolla
RECRUITING

La Jolla, California, 92037, United States
Virginia Commonwealth University (VCU) Medical Center
RECRUITING

Richmond, Virginia, 23298, United States
Winship Cancer Institute of Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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