New hope for sickle cell: experimental drug BMS-986470 enters human trials
NCT ID NCT06481306
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 38 times
Summary
This study tests a new drug called BMS-986470 in healthy volunteers and people with sickle cell disease. The goal is to check its safety, how the body processes it, and whether it might help control the disease. About 184 participants will receive either the drug or a placebo in this early-stage trial.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
RECRUITINGMarseille, 13385, France
Contact Phone: •••-•••-••••
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02118, United States
Contact Phone: •••-•••-••••
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Hôpital Universitaire Necker Enfants Malades
RECRUITINGParis, 75015, France
Contact Phone: •••-•••-••••
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Inova Schar Cancer Institute
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-••••
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Institut de cancérologie Strasbourg Europe (ICANS)
RECRUITINGStrasbourg, Alsace, 67033, France
Contact Phone: •••-•••-••••
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King's College Hospital
RECRUITINGLondon, London, City of, SE5 9RL, United Kingdom
Contact
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Local Institution - 0001
ACTIVE_NOT_RECRUITINGLenexa, Kansas, 66219, United States
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Local Institution - 0005
NOT_YET_RECRUITINGLeeds, LS9 7TF, United Kingdom
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Local Institution - 0009
NOT_YET_RECRUITINGVerona, 37134, Italy
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Local Institution - 0011
NOT_YET_RECRUITINGMilan, Lombardy, 20122, Italy
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Local Institution - 0024
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
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Local Institution - 0027
NOT_YET_RECRUITINGGreenville, South Carolina, 29605, United States
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Local Institution - 0028
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
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Local Institution - 0029
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Local Institution - 0030
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
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Local Institution - 0032
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Local Institution - 0033
NOT_YET_RECRUITINGGreenville, North Carolina, 27834, United States
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Local Institution - 0034
NOT_YET_RECRUITINGChicago, Illinois, 60612, United States
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Local Institution - 0035
NOT_YET_RECRUITINGTampa, Florida, 33607, United States
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Local Institution - 0037
NOT_YET_RECRUITINGPadua, 35128, Italy
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Local Institution - 0044
NOT_YET_RECRUITINGLondon, Greater London, SE19RT, United Kingdom
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Local Institution - 0047
NOT_YET_RECRUITINGLondon, W12 0HS, United Kingdom
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Local Institution - 0050
NOT_YET_RECRUITINGVancouver, British Columbia, V621Y6, Canada
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Local Institution - 0051
NOT_YET_RECRUITINGToronto, Ontario, M5G 2C4, Canada
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Local Institution - 0061
NOT_YET_RECRUITINGCréteil, 94000, France
Contact
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Local Institution - 0064
NOT_YET_RECRUITINGBaltimore, Maryland, 21287, United States
Contact
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Thomas Jefferson University - Medicine/GI and Hepatology
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-••••
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
Contact
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University Hospitals Sussex NHS Foundation Trust
RECRUITINGEast Sussex, Brighton And Hove, BN2 1ES, United Kingdom
Contact Phone: •••-•••-••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-••••
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University of California San Diego - La Jolla
RECRUITINGLa Jolla, California, 92037, United States
Contact Phone: •••-•••-••••
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Virginia Commonwealth University (VCU) Medical Center
RECRUITINGRichmond, Virginia, 23298, United States
Contact Phone: •••-•••-••••
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Winship Cancer Institute of Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-••••
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Yale-New Haven Hospital
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact Phone: •••-•••-••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BMS-986470
What this could lead to
If successful, this could point toward a new treatment option for sickle cell disease, potentially reducing pain crises and complications.
What could go wrong
This is an early phase 1/2a trial with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or not work as hoped.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.