One shot for two threats? BioNTech tests combo Flu-COVID vaccine

NCT ID NCT06821061

Completed ⭐️ VACCINE ⭐️ Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested new modified RNA vaccines that target both influenza and COVID-19, given as a single shot. Over 2,600 healthy adults aged 18 and older took part, receiving either a flu vaccine, a COVID-19 vaccine, or a combination of both. The main goal was to check safety and how well the body's immune system responds, with results expected to guide future vaccine development.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: modified RNA vaccine (combined influenza and COVID-19)
What this could lead to: If successful, this could lead to a single annual shot that protects against both flu and COVID-19, simplifying vaccination schedules.
What could go wrong: This is an early-phase trial focused on safety and immune response, not yet proven to prevent illness. The combined vaccine may not work as well as separate shots, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 (CORONAVIRUS DISEASE 2019) INFLUENZA

Contacts and locations

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Locations

AMR Clinical

Knoxville, Tennessee, 37909, United States
AMR Clinical

Knoxville, Tennessee, 37920, United States
Alliance for Multispecialty Research, LLC

Doral, Florida, 33172, United States
Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States
Artemis Institute for Clinical Research

Riverside, California, 92503, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Centricity Research Columbus Ohio Multispecialty

Columbus, Ohio, 43213, United States
Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
Clinical Research Associates Inc

Nashville, Tennessee, 37203, United States
Clinical Research Atlanta

Stockbridge, Georgia, 30281, United States
Clinical Research Consulting

Milford, Connecticut, 06460, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
DM Clinical Research - Philadelphia

Philadelphia, Pennsylvania, 19107, United States
DM Clinical Research- Cyfair

Houston, Texas, 77065, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research

Tomball, Texas, 77375, United States
East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States
Headlands Horizons, LLC dba Headlands Research-Brownsville

Brownsville, Texas, 78526, United States
Indago Research & Health Center, Inc

Hialeah, Florida, 33012, United States
J. Lewis Research, Inc. / Foothill Family Clinic

Salt Lake City, Utah, 84109, United States
J. Lewis Research, Inc. / Foothill Family Clinic South

Salt Lake City, Utah, 84121, United States
Kaiser Permanente Washington Health Research Institute (KPWHRI)

Seattle, Washington, 98101, United States
Las Vegas Clinical Trials

North Las Vegas, Nevada, 89030, United States
Miami Dade Medical Research Institute, LLC

Miami, Florida, 33176, United States
Orange County Research Center

Lake Forest, California, 92630, United States
Palm Springs Community Health Center

Miami Lakes, Florida, 33014, United States
SMS Clinical Research

Mesquite, Texas, 75149, United States
Trial Management Associates - Wilmington - Floral Parkway

Wilmington, North Carolina, 28403, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
Upstate Global Health Institute

East Syracuse, New York, 13057, United States

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