INFLUENZA

This study tests three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma, including those who had a stem cell transplant or CAR-T therapy. The goal is to see which vaccine triggers the strongest immune response. Results will help doctors choose the …

This study compares a high-dose flu vaccine to the standard dose in children aged 3-17 who received a kidney, heart, or liver transplant within the past 2 years. The goal is to see if the high-dose vaccine triggers a stronger immune response and is safe. About 312 children will t…

This study tests an experimental flu vaccine called BPL-1357 in 129 healthy adults aged 18 to 55. The vaccine is given as a shot or nasal spray, and participants are later exposed to the flu virus in a controlled hospital setting to see if the vaccine prevents illness. The goal i…

This study tests a new seasonal flu vaccine made from plants in about 728 adults aged 18 and older. The goal is to see if it is safe and triggers a strong immune response compared to a standard flu shot. Researchers will monitor side effects and measure antibody levels over six m…

This study is for healthy adults aged 22 to 50 in Hong Kong. It aims to understand how getting a flu vaccine every year affects your body's immune response. Researchers will compare two types of flu vaccines (Flublok and FluMist) to see how well they work and why some people stil…

This study tests a new flu vaccine in 150 healthy pregnant women aged 18-39, who are 20-32 weeks pregnant. Half get the new vaccine, half get an existing one. Researchers check blood samples before and after vaccination, and at delivery, to see if the vaccine triggers protective …

This early-stage trial tests a new flu vaccine in 120 adults aged 60 and older. Participants receive either the new vaccine, a standard flu vaccine, or a placebo. The study checks for side effects and measures immune response to see if the new vaccine is safe and works well.

This study tests a new mRNA vaccine (mRNA-1018-H5) designed to protect adults 18 and older from H5N1 bird flu, a virus that could cause a future pandemic. About 4,000 healthy volunteers will receive two doses of the vaccine or a placebo to see if it triggers a strong immune respo…

This study looks at the best way to give COVID-19 booster and flu shots to people with weakened immune systems (like those with rheumatoid arthritis, organ transplants, or HIV). It will compare getting both vaccines on the same day versus one month apart, and also test if getting…

This study looks at whether a high-dose flu vaccine given over two flu seasons works better than the standard-dose vaccine for lung transplant recipients. These patients must take lifelong anti-rejection drugs, which weaken their immune system and make them very vulnerable to inf…

This study tests how well different antiviral drugs clear the flu virus from the body. It involves 3000 adults aged 18-60 with early flu symptoms. Participants are randomly assigned to receive an antiviral or no treatment, and their viral levels are tracked daily for a week. The …

This early-stage study tests the safety of an experimental oral drug called VNT-101 in healthy adults aged 18 to 59. The study will give single or multiple doses to see how the body handles the drug and if any side effects occur. It does not aim to treat or cure influenza, but to…

This study tests whether combining two antiviral drugs, baloxavir and oseltamivir, can better treat severe flu in people who have had a stem cell transplant or have blood cancer. About 60 participants will receive the combo or standard care. The goal is to see if the combination …

This study has two main goals. First, it will check if the flu virus in children under 12 becomes resistant to the medicine baloxavir marboxil. Second, for a smaller group of families, it will track whether the flu spreads from the treated child to other people living in the same…

This study tests whether giving antiviral drugs to uninfected hospital roommates of flu patients can prevent them from catching the flu. About 384 participants will be randomly assigned to receive either a placebo, suraxavir marboxil, or oseltamivir. The goal is to see which drug…

This study aims to see if a standardized program can increase flu vaccination rates for children while they are in the hospital. Researchers will work with parents, doctors, and nurses to create a best-practice guide and test it across multiple US children's hospitals. About 22,0…

This study compares a high-dose flu vaccine to the standard dose in 270 lung transplant recipients. The goal is to see if the high-dose shot provides better protection against influenza, which can be very dangerous for these patients. Participants will receive two doses of either…

This study is testing whether a supplement called IDP can make colds and flu shorter and less severe in people aged 60 and older. About 300 participants will take either the supplement or a placebo daily during cold and flu season, reporting their symptoms through a smartphone ap…

This study tests whether a higher-dose version of the antiviral drug Ingavirin can help people with flu or other viral respiratory infections feel better faster. About 300 adults aged 18 to 65 with confirmed infections will receive either the new dose, the standard dose, or a pla…

This study aims to find the right dose of a flu virus that can safely cause mild flu symptoms in healthy adults. About 90 volunteers aged 18 to 55 will be given either the virus or a placebo. The goal is to create a reliable model for testing future flu vaccines and treatments.

This study follows 150 NIH employees who plan to get the flu and/or COVID-19 vaccine. Researchers will take blood and nasal samples monthly for about a year to see how the body's immune system responds to the vaccines. No vaccines or treatments are given as part of the study—it i…

This study looks at how breathing in woodsmoke changes the way your nose and immune system react to the flu virus. Healthy adults aged 18-49 will be exposed to woodsmoke and then given a live but weakened flu vaccine to mimic infection. Researchers will measure immune markers and…

This study looks back at the medical records of up to 400,000 Veterans to see how COVID-19 treatments were used over time and how well they worked. Researchers will also compare treatments for flu and RSV. The goal is to learn which therapies are most effective and for whom, with…

This study collects nose and blood samples from people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The goal is to learn more about these viruses and how the body fights them. Samples will be stored for future research, including vaccine develop…

This study looks at how the immune system reacts to influenza and COVID-19 in people with symptoms. Researchers will compare those who got a flu or COVID vaccine in the past year with those who did not. About 300 participants will provide blood, saliva, and nasal samples over 6 m…

This study gives healthy adults the flu virus in a controlled hospital setting to closely watch how the immune system fights it and how the virus spreads. The goal is to learn more about the flu so we can create better vaccines and medicines. Participants stay in the hospital for…

This study aims to learn how the immune system reacts to the flu virus and how the virus spreads. Healthy adults aged 18-49 will be intentionally infected with a lab-made H3N2 flu virus in a controlled setting. The goal is to observe mild to moderate flu symptoms and track the vi…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu, COVID-19, or other respiratory viruses raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to pr…

This study looks at how the immune system of adults over age 75 responds to the annual flu shot. Researchers want to know if a common virus called CMV affects that response. About 1,025 healthy or frail older adults will join. Participants get the flu shot for free and provide bl…

This study looks at whether community health workers sharing personal stories on social media can encourage people to get recommended vaccines for flu, COVID-19, and other respiratory viruses. About 1,400 health workers and their followers will take part. Researchers will measure…

This study looks at whether drinking pasteurized milk that contains harmless, inactive pieces of the H5 flu virus could cause a positive flu test from a nose or throat swab. The goal is to help the CDC improve flu surveillance by understanding how milk consumption might affect te…

This study looks at how approved seasonal flu vaccines affect the body's immune response in younger adults (ages 18-50) and older adults (ages 65-80). Researchers will measure antibodies and memory B cells in the blood to see how age and past vaccination history change the way th…

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track things like temperature, heart rate, coughing, and voice changes. The goal is to see if these digital devices can…

This study tests a web-based educational program called InTroDuce-Programme for pregnant women in Malaysia. The goal is to see if it improves their knowledge about flu and Tdap vaccines and increases their intention to get vaccinated. About 351 pregnant women will take part, and …

This study looks at how the immune system reacts to the flu in two different ways: getting a nasal spray vaccine or being exposed to a controlled dose of live flu virus. Researchers want to understand the differences in symptoms and immune responses between vaccination and actual…

This study screens healthy adults aged 18 to 65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a medical check-up, blood tests, and heart exam. No treatment is given—the goal is to build a pool of eligible participants for lat…

This study compares how well two FDA-approved COVID-19 vaccines (Novavax and Pfizer-BioNTech) and flu vaccines work in adults aged 18-79 who have health risks like asthma, heart disease, or depression. Researchers will measure immune responses and side effects over time. The goal…