Could a Double-Dose flu vaccine better protect transplant kids?

NCT ID NCT05947071

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a high-dose flu vaccine to the standard dose in 312 children aged 3-17 who have received a kidney, heart, or liver transplant within the past two years. The goal is to see if the high-dose vaccine triggers a stronger immune response and is just as safe. Participants will receive two doses of either vaccine, one month apart.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Influenza vaccine (high-dose or standard-dose quadrivalent inactivated)
What this could lead to: If successful, this could show that a high-dose flu vaccine provides better protection for children with organ transplants, reducing flu-related complications.
What could go wrong: This is a phase 2 trial with 312 participants, so results are still early. The high-dose vaccine may not prove more effective or could cause more side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

disease related to transplantation Infections infectious disease influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNIZATION; INFECTION INFLUENZA TRANSPLANTATION INFECTION

Contacts and locations

Locations

Ann Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60614, United States
Children's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30322, United States
Children's Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt
RECRUITING

Nashville, Tennessee, 37232, United States
Stanford University
RECRUITING

Stanford, California, 94305, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
UPMC Children's Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

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