Scientists to compare nasal flu vaccine with real flu infection in healthy volunteers
NCT ID NCT06620185
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will compare immune responses in 36 healthy adults aged 18-55 who either receive a nasal spray flu vaccine or are deliberately infected with a controlled dose of influenza A (H3N2) virus. Researchers will track symptoms and measure immune markers in the blood and respiratory tract over 14 days. The goal is to better understand how the body fights flu after vaccination versus natural infection, which could inform future vaccine development.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Live-attenuated influenza vaccine (nasal spray) and influenza A (H3N2) challenge virus
What this could lead to
If successful, this could help researchers better understand how the immune system responds to flu vaccination versus natural infection, potentially improving future vaccines.
What could go wrong
This is a small, early-stage study with only 36 healthy adults, so results may not apply to the general population. The viral challenge involves deliberate infection, which carries risks of flu-like symptoms.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Imperial Clinical Research Facility, Imperial College Healthcare NHS Trust
RECRUITINGLondon, W12 0HS, United Kingdom
Contact
Contact Email: •••••@•••••