Scientists to compare nasal flu vaccine with real flu infection in healthy volunteers
NCT ID NCT06620185
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will compare immune responses in 36 healthy adults aged 18-55 who either receive a nasal spray flu vaccine or are deliberately infected with a controlled dose of influenza A (H3N2) virus. Researchers will track symptoms and measure immune markers in the blood and respiratory tract over 14 days. The goal is to better understand how the body fights flu after vaccination versus natural infection, which could inform future vaccine development.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Live-attenuated influenza vaccine (nasal spray) and influenza A (H3N2) challenge virus
- What this could lead to
- If successful, this could help researchers better understand how the immune system responds to flu vaccination versus natural infection, potentially improving future vaccines.
- What could go wrong
- This is a small, early-stage study with only 36 healthy adults, so results may not apply to the general population. The viral challenge involves deliberate infection, which carries risks of flu-like symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INFLUENZA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Imperial Clinical Research Facility, Imperial College Healthcare NHS Trust
RECRUITINGLondon, W12 0HS, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Flu vaccine showdown: which shot protects seniors best?
- Can a simple breath test catch flu in High-HIV regions?
- Can a simple mask stop the flu? 2,000 volunteers put it to the test
- Can a stronger flu shot better protect seniors?
- Flu shot showdown: Cell-Grown vs recombinant vaccine put to the test
- New mRNA vaccine aims to outsmart flu by targeting its hidden parts